CALPHOSTIN C
- CAS No.
- 121263-19-2
- Chemical Name:
- CALPHOSTIN C
- Synonyms
- UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384
- CBNumber:
- CB7457711
- Molecular Formula:
- C44H38O14
- Molecular Weight:
- 790.76
- MDL Number:
- MFCD00133155
- MOL File:
- 121263-19-2.mol
- MSDS File:
- SDS
| Boiling point | 1039.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/mL |
| form | powder |
| pka | 7.30±0.20(Predicted) |
| color | red to brown |
| EWG's Food Scores | 1 |
| FDA UNII | I271P23G24 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| HS Code | 29209010 |
CALPHOSTIN C price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6303 | Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder | 121263-19-2 | 0.1mg | $254.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | C6303 | Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder | 121263-19-2 | 1mg | $812 | 2024-03-01 | Buy |
| Sigma-Aldrich | 208725 | Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t | 121263-19-2 | 50μg | $154 | 2023-01-07 | Buy |
| Sigma-Aldrich | 208725 | Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t | 121263-19-2 | 100μg | $264 | 2023-01-07 | Buy |
| Alfa Aesar | J60647 | Calphostin C, 95% | 121263-19-2 | 100microg | $238 | 2023-06-20 | Buy |
CALPHOSTIN C Chemical Properties,Uses,Production
Chemical Properties
Dark red solid
Uses
Potent inhibitor of protein kinase C
Uses
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
Uses
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).
Biochem/physiol Actions
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.
storage
+4°C (desiccate)
CALPHOSTIN C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |