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Fipronil

Fipronil
Fipronil structure
CAS No.
120068-37-3
Chemical Name:
Fipronil
Synonyms
REGENT;PRINCE;ipronil;FIPRONIL;m&b46030;Combat F;Termidor;Regent TS;TopChoice;1fipronil
CBNumber:
CB7461570
Molecular Formula:
C12H4Cl2F6N4OS
Formula Weight:
437.15
MOL File:
120068-37-3.mol

Fipronil Properties

Melting point:
200-201°C
Boiling point:
510.1±50.0 °C(Predicted)
Density 
1.477-1.626
vapor pressure 
3.7×10-7 Pa (25 °C)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
pka
-5.86±0.20(Predicted)
Water Solubility 
1.9-2.4 mg 1l-1 (20 °C)
form 
neat
λmax
208nm(H2O)(lit.)
Merck 
14,4085
BRN 
8090115
CAS DataBase Reference
120068-37-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
QGH063955F
Pesticides: Freedom of Information Act (FOIA)
Fipronil
EPA Substance Registry System
Fipronil (120068-37-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H319-H372-H410
Precautionary statements  P261-P273-P280-P301+P310+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  T,N
Risk Statements  23/24/25-48/25-50/53-55-57-36
Safety Statements  26-36/37/39-45-60-61-36/37-28
RIDADR  2588
WGK Germany  3
RTECS  UQ4430250
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331990
Toxicity LD50 in rats (mg/kg): 100 orally; >2000 dermally (Colliot); in mice (mg/kg): 32 i.p. (Cole)

Fipronil price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 16785 Fipronil certified reference material, TraceCERT 120068-37-3 50mg $96.9 2020-08-18 Buy
Sigma-Aldrich 46451 Fipronil PESTANAL 120068-37-3 100mg $201 2021-03-22 Buy
TCI Chemical F0822 Fipronil 120068-37-3 5G $372 2021-03-22 Buy
TCI Chemical F0822 Fipronil 120068-37-3 1G $124 2021-03-22 Buy
Cayman Chemical 24128 Fipronil ≥95% 120068-37-3 50mg $25 2021-03-22 Buy

Fipronil Chemical Properties,Uses,Production

Description

Fipronil is a white powder with a mouldy odour. It has a low solubility in water and is a slow-acting poison. It does not bind strongly with soil, and the half-life of fipronil– sulphone is 34 days. Fipronil is a broadspectrum insecticide of the phenylpyrazole group. Fipronil was first used extensively for the control of ants, beetles, cockroaches, fleas; ticks, termites, mole crickets, thrips, rootworms, weevils, flea of pets, field pest of corn, golf courses, and commercial turf, and other insects. Fipronil was first used in the United States in 1996. Fipronil is a topical insecticide. It kills adult fleas and larvae, ticks, and chewing lice. As a liquid, fipronil is applied on the back side skin of dogs and cats. Reports indicate that some animals do become hypersensitive (allergic) to fipronil.

Chemical Properties

White crystalline solid.

Chemical Properties

White SOlid

Uses

antifungal

Uses

Pesticide.

Uses

A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors.

Uses

Fipronil is used for the control of a wide range of insect species in rice, cereals, corn, cotton, top fruit, sugar beet, sugar cane, oilseed rape, many vegetables and other high-value crops. It also has a veterinary use as an ectoparasiticide.

Agricultural Uses

Insecticide, Veterinary medicine: Not approved for use in EU countries. Fipronil was introduced into the U.S. in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic animal and residential pests.

Trade name

BES® 602; CEASEFIRE®; CHIPCO®; COMBAT®; FRONTLINE; MB-46030®; H&G®; ICON®; MAXFORCE® ANT STATION; MAXFORCE® ROACH STATION; REGENCY SOFION®; REGENT®; REGENT® 500-FS; TERMIDOR® L VI-NIL

Pharmacology

Fipronil is a phenylpyrazole, the mode of action of which is to inhibit nerve transmission in arthropods by blocking γ -aminobutyric acid-gated chloride channels. Fipronil is available as spray and spot-on formulations to control fleas and ticks on cats and dogs. The adulticidal activity of fipronil accounts for the majority of its activity, although additional activity against flea eggs and larvae results from the presence of fipronil on hairs and debris shed into the environment from treated pets.
Autohistoradiography studies (11) into the cutaneous distribution of 14C-fipronil in the cat and dog following spot-on administration demonstrated that radioactivity was restricted principally to the stratum corneum, the viable epidermis, and the pilosebaceous units. Following its slow release from sebaceous glands, fipronil migrates in the sebum covering the skin and hairs by passive diffusion and was shown to persist on hair for up to 2 months after treatment.

Potential Exposure

Pyrazole/phenylpyrazole/organofluor ine insecticide; veterinary medicine. Fipronil was intro duced into the United States in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic ani mal and residential pests. Banned for use in EU.

Metabolic pathway

Through the abiotic degradation of fipronil in aqueous solution and on the soil surface, 5-amino-3- carbamoyl-1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4- [(trifluoromethyl)sulfinyl]pyrazole is the only hydrolysis product detected. Fipronil in acidic aqueous solution exposed under a xenon lamp degrades with the concomitant appearance of 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)-phenyl]-4- (trifluoromethyl)pyrazole and 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)phenyl]pyrazole-4-sulfonic acid. Under field conditions, when fipronil is applied in formulation, four metabolites which include one product resulting from reduction on the sulfur atom of fipronil are detected.

Shipping

UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Degradation

Fipronil is stable in water at pH 5 and 7 but is slowly hydrolysed at pH 9 (DT50 28 days) to the amide (2). It undergoes rapid aqueous photolysis with a DT50 of ﹤0.5 day. The major photodecomposition product in water and on soil surfaces is desulfinyl-fipronil(3) which is formed by extrusion of the SO group. A minor photoproduct in water, on soil and on plant surfaces is the sulfonic acid (4). The mechanisms of these reactions are discussed in a recent paper by Bobe et al. (1998).

Toxicity evaluation

Acute oral LD50 for rats: 100 mg/kg

Waste Disposal

It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a haz ardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and fol low all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and dis posal methods.

Fipronil Preparation Products And Raw materials

Raw materials

Preparation Products


Fipronil Suppliers

Global( 403)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Masteam Bio-tech Co., Ltd.
86-15897918789 86-15200345168
bruce.lei@masteam.com CHINA 153 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4104 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
Hebei Yanxi Chemical Co., Ltd.
+8618633081222
peter@yan-xi.com CHINA 688 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55

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View Lastest Price from Fipronil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Fipronil
120068-37-3
US $6.00 / Kg/Bag 1g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-25 Fipronil
120068-37-3
US $6.00 / g 100g 99.99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-15 Fipronil
120068-37-3
US $110.00 / KG 1KG 99% 200000pcs Hebei Yirun Sega Biological Technology Co. Ltd

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