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ZOTEPINE

CAS No.
26615-21-4
Chemical Name:
ZOTEPINE
Synonyms
Setous;lodopin;zotepina;ZOTEPINE;Majorpin;Etoxazole Impurity 9;8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin;f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(;2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine;2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
CBNumber:
CB7461848
Molecular Formula:
C18H18ClNOS
Molecular Weight:
331.86
MDL Number:
MFCD00868143
MOL File:
26615-21-4.mol
Last updated:2023-09-20 16:43:00

ZOTEPINE Properties

Melting point 90-91°
Boiling point 478.4±45.0 °C(Predicted)
Density 1.0675 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. Store at RT
solubility DMSO: ≥20mg/mL
pka 8.72±0.28(Predicted)
form powder
color white to off-white
FDA UNII U29O83JAZW
ATC code N05AX11

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H410
Precautionary statements  P264-P270-P273-P301+P310-P391-P405
Hazard Codes  T
Risk Statements  25-50/53
Safety Statements  45-60-61
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Toxicity LD50 in male mice, rats (mg/kg): 108, 458 orally; 43.3, 39.7 i.v.; 40.0, 97.0 i.p.; 84.9, 2080 s.c. (Fukuhara)
NFPA 704
0
2 0

ZOTEPINE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z0877 Zotepine >98% (HPLC) 26615-21-4 10mg $88.8 2024-03-01 Buy
Sigma-Aldrich Z0877 Zotepine >98% (HPLC) 26615-21-4 50mg $269 2024-03-01 Buy
Cayman Chemical 23909 Zotepine ≥98% 26615-21-4 10mg $62 2024-03-01 Buy
Cayman Chemical 23909 Zotepine ≥98% 26615-21-4 25mg $142 2024-03-01 Buy
Cayman Chemical 23909 Zotepine ≥98% 26615-21-4 50mg $270 2024-03-01 Buy
Product number Packaging Price Buy
Z0877 10mg $88.8 Buy
Z0877 50mg $269 Buy
23909 10mg $62 Buy
23909 25mg $142 Buy
23909 50mg $270 Buy

ZOTEPINE Chemical Properties,Uses,Production

Chemical Properties

White to off white crystalline powder

Originator

Lodopin,Fujisawa Pharmaceutical,Japan,1982

Uses

antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist

Definition

ChEBI: Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.

Manufacturing Process

A suspension of 30 g of sodium hydride in benzene (30 ml) was added dropwise to 52 g of 8-chlorodibenzo[b,f]thiepin-10(11H)-one dissolved in dimethylformamide (800 ml), and the mixture was heated at 100°C for 2 hours. To this, there were added 68 g of 2-dimethylaminoethyl chloride, and the mixture was heated at 60°C for 39 hours. The reaction mixture, after cooled, was poured into ice-water, and the solution was extracted with ethyl acetate. The ethyl acetate layer, after washed with water, was extracted with 10% hydrochloric acid, when oil was precipitated. The aqueous layer, in which oil was precipitated, was washed with ether, made neutral with concentrated sodium hydroxide solution and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give oil, which was allowed to stand to provide solid. The solid was washed with petroleum ether and recrystallized from cyclohexane to yield 42.5 g of 8-chloro-10-(2-dimethylaminoethyl)-oxydibenzo[b,f]thiepin as crystals, melting point 90°C to 91°C. Maleate as colorless needle, melting point 204°C to 204.5°C.

Therapeutic Function

Tranquilizer

ZOTEPINE Preparation Products And Raw materials

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
LUYUNJIA CHEMISTRY XIAMEN LIMITED
+86-592-5360779 +86-13055435203 China 5996 58

View Lastest Price from ZOTEPINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZOTEPINE pictures 2022-04-24 ZOTEPINE
26615-21-4
US $11.00 / kg 1kg 99 5000 Jiangsu Bangdeya New Material Technology Co.,Ltd
ZOTEPINE pictures 2022-02-18 ZOTEPINE
26615-21-4
US $0.00 / gram 1gram 99% 10kg Zhejiang J&C Biological Technology Co.,Limited
  • ZOTEPINE pictures
  • ZOTEPINE
    26615-21-4
  • US $11.00 / kg
  • 99
  • Jiangsu Bangdeya New Material Technology Co.,Ltd
  • ZOTEPINE pictures
  • ZOTEPINE
    26615-21-4
  • US $0.00 / gram
  • 99%
  • Zhejiang J&C Biological Technology Co.,Limited

26615-21-4(ZOTEPINE)Related Search:

ZOTEPINE 2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-n,n-dimethylethanamine 2-chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin 2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin 2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo( lodopin zotepina 8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin Majorpin N,N-Dimethyl-2-(2-chlorodibenzo[b,f]thiepin-11-yloxy)ethylamine Setous 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxyethyl-dimethyl-amine 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethylethanamine 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethyl-ethanamine 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine 2-[(3-chloro-5-benzo[b][1]benzothiepinyl)oxy]-N,N-dimethylethanamine Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl- ZotepineQ: What is Zotepine Q: What is the CAS Number of Zotepine Q: What is the storage condition of Zotepine Q: What are the applications of Zotepine 5-HT Receptor,antipsychotic,antidepressive,Serotonin Receptor,Inhibitor,anxiolytic,inhibit,5-hydroxytryptamine Receptor,Zotepine,Adrenergic Receptor,Beta Receptor,Histamine Receptor,Dopamine Receptor Etoxazole Impurity 9 26615-21-4 Pharmaceutical intermediate