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SKA-121

SKA-121 structure

CAS No.: 1820708-73-3

Chemical Name:: SKA-121

Synonyms: SKA-121;SKA121,SKA 121;Naphth[2,1-d]oxazol-2-amine, 5-methyl-;SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin

CBNumber:: CB74667080

Molecular Formula:: C12H10N2O

Molecular Weight:: 198.22

MDL Number:: MFCD31630822

MOL File:: 1820708-73-3.mol

MSDS File:: SDS

Last updated:2023-07-12 17:01:48

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SKA-121 Properties

Boiling point	403.2±38.0 °C(Predicted)
Density	1.302±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form	powder
pka	4.48±0.30(Predicted)
color	brown to dark gray

SKA-121 price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2206	SKA-121 ≥98% (HPLC)	1820708-73-3	5mg	$105	2024-03-01	Buy
Sigma-Aldrich	SML2206	SKA-121 ≥98% (HPLC)	1820708-73-3	25mg	$338	2024-03-01	Buy
Cayman Chemical	9003088	SKA-121 ≥98%	1820708-73-3	1mg	$27	2024-03-01	Buy
Cayman Chemical	9003088	SKA-121 ≥98%	1820708-73-3	25 mg	$565	2024-03-01	Buy
Cayman Chemical	9003088	SKA-121 ≥98%	1820708-73-3	500μg	$43	2023-01-06	Buy

Product number	Packaging	Price	Buy
SML2206	5mg	$105	Buy
SML2206	25mg	$338	Buy
9003088	1mg	$27	Buy
9003088	25 mg	$565	Buy
9003088	500μg	$43	Buy

SKA-121 Chemical Properties,Uses,Production

Biochem/physiol Actions

SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).

storage

Store at -20°C

SKA-121 Preparation Products And Raw materials

Raw materials

Preparation Products

SKA-121 Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2983	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19105	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
BOC Sciences	65
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Rechem science Co., Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	58
DC Chemicals	58

SKA-121 Naphth[2,1-d]oxazol-2-amine, 5-methyl- SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin SKA121,SKA 121 1820708-73-3