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DS-437

DS-437 Structure
DS-437 structure
CAS No.
1674364-87-4
Chemical Name:
DS-437
Synonyms
DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
CBNumber:
CB74669958
Molecular Formula:
C15H23N7O4S
Molecular Weight:
397.45
MDL Number:
MFCD32661891
MOL File:
1674364-87-4.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:12
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DS-437 Properties

Density 1.71±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)
pka 13.13±0.70(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P330+P331+P310
RIDADR  UN 2811 6.1 / PGIII
NFPA 704
0
2 0

DS-437 price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1516 DS-437 ≥98% (HPLC) 1674364-87-4 5MG $105 2023-06-20 Buy
Sigma-Aldrich SML1516 DS-437 ≥98% (HPLC) 1674364-87-4 25MG $424 2023-06-20 Buy
Cayman Chemical 29476 DS-437 1674364-87-4 1mg $36 2024-03-01 Buy
Cayman Chemical 29476 DS-437 1674364-87-4 5mg $105 2024-03-01 Buy
Cayman Chemical 29476 DS-437 1674364-87-4 10mg $188 2024-03-01 Buy
Product number Packaging Price Buy
SML1516 5MG $105 Buy
SML1516 25MG $424 Buy
29476 1mg $36 Buy
29476 5mg $105 Buy
29476 10mg $188 Buy

DS-437 Chemical Properties,Uses,Production

Description

DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5.

Uses

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Biochem/physiol Actions

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

DS-437 Preparation Products And Raw materials

Raw materials

Preparation Products

DS-437 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
InvivoChem 13549236410 sales@invivochem.cn China 6712 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
Sigma-Aldrich 80
Shanghai Hongye Biotechnology Co. Ltd 58
DC Chemicals 58
Energy Chemical 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
DS-437 DS-437 (DS437 Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio- DS-437 >=98% (HPLC) 1674364-87-4 C15H23N7O4S