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TH1020

TH1020 structure

CAS No.: 1841460-82-9

Chemical Name:: TH1020

Synonyms: TH1020;TH1020 >=95% (HPLC);4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2';4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-;interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020

CBNumber:: CB74670635

Molecular Formula:: C23H15N7S2

Molecular Weight:: 453.54

MDL Number:: MFCD30480930

MOL File:: 1841460-82-9.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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TH1020 Properties

Boiling point	765.8±70.0 °C(Predicted)
Density	1.51±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform: 1 mg/ml
form	powder
pka	1.92±0.10(Predicted)
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

NFPA 704

	0
2		0

TH1020 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1741	TH1020 ≥95% (HPLC)	1841460-82-9	5MG	$107	2023-06-20	Buy
Sigma-Aldrich	SML1741	TH1020 ≥95% (HPLC)	1841460-82-9	25MG	$434	2023-06-20	Buy
Tocris	6191	TH1020 ≥98%(HPLC)	1841460-82-9	10	$132	2021-12-16	Buy
Tocris	6191	TH1020 ≥98%(HPLC)	1841460-82-9	50	$552	2021-12-16	Buy
TRC	T430010	TH1020	1841460-82-9	50mg	$525	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1741	5MG	$107	Buy
SML1741	25MG	$434	Buy
6191	10	$132	Buy
6191	50	$552	Buy
T430010	50mg	$525	Buy

TH1020 Chemical Properties,Uses,Production

Uses

TH 1020 is a toll-like receptor 5 (TLR5)/flagellin complex inhibitor.

Uses

TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.

Biochem/physiol Actions

TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.

storage

Store at +4°C

TH1020 Preparation Products And Raw materials

Raw materials

Preparation Products

TH1020 Suppliers

Global( 28)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Jingmo (Xiamen) Biotechnology Co., Ltd	13621943973 13515979683	sales@jamxmpharmatech.com	China	1079	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9440	58
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29797	68
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Jingmo (Xiamen) Biotechnology Co., Ltd	58
BOC Sciences	65
Sigma-Aldrich	80
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Beijing Jin Ming Biotechnology Co., Ltd.	58

TH1020 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2' TH1020 >=95% (HPLC) 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020 Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]- 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine 1841460-82-9