ACEA
- CAS No.
- 220556-69-4
- Chemical Name:
- ACEA
- Synonyms
- ACEA;2'-CHLORO-AEA;ACEA (ethanol solution);Terfenadine Impurity 23;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONYL-2'-CHLOROETHYLAMIDE;ARACHIDONOYL 2'-CHLOROETHYLAMIDE;Eicosapentaenoic Acid Impurity 51;ARACHIDONYL-2'-CHLOROETHYLAMIDE HYDRATE;N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- CBNumber:
- CB7484072
- Molecular Formula:
- C22H36ClNO
- Molecular Weight:
- 365.98
- MDL Number:
- MFCD02683581
- MOL File:
- 220556-69-4.mol
ACEA price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9719 | Arachidonyl-2′-chloroethylamide hydrate ≥97% (HPLC), oil | 220556-69-4 | 25mg | $398 | 2024-03-01 | Buy |
| Alfa Aesar | J67294 | N-Arachidonyl-2-chloroethylamide, 98% | 220556-69-4 | 10mg | $117 | 2022-04-27 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2'-Chloroethylamide ≥95% | 220556-69-4 | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2'-Chloroethylamide ≥95% | 220556-69-4 | 10mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 91054 | Arachidonoyl 2'-Chloroethylamide ≥95% | 220556-69-4 | 25mg | $166 | 2024-03-01 | Buy |
ACEA Chemical Properties,Uses,Production
Description
Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).
Definition
ChEBI: Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid.
Biological Activity
Potent and highly selective CB 1 receptor agonist (K i = 1.4 nM). Displays > 1400-fold selectivity over CB 2 receptors. Active in vivo . Also available as part of the Cannabinoid CB 1 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective neuronal CB1 cannabinoid receptor agonist.
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N- arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki = 1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM). ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [ 35 S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. ACEA produces hypothermia in mice, an effect that is inhibited by co-administration of the CB1 receptor antagonist SR141716A.
storage
Store at -20°C
ACEA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai Xingui Biotechnology Co., Ltd. | 17501653713 17501653715 | xingui2022@126.com | China | 9992 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15878 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |