METHACHOLINE BROMIDE
- CAS No.
- 333-31-3
- Chemical Name:
- METHACHOLINE BROMIDE
- Synonyms
- Methacholine;Acetyl-βMECHOLYL BROMIDE;METHACHOLINE BROMIDE;METHYLCHOLINE BROMIDE;MethacholineBromide>(2-HYDROXYPROPYL)TRIMET;ACETYL-β-METHYLCHOLINEBROMID;ACETYL-B-METHYLCHOLINE BROMIDE;Acetyl-β-methylcholine bromide
- CBNumber:
- CB7489800
- Molecular Formula:
- C8H18BrNO2
- Molecular Weight:
- 240.14
- MDL Number:
- MFCD00011816
- MOL File:
- 333-31-3.mol
- MSDS File:
- SDS
| Melting point | 147-149 °C(lit.) |
|---|---|
| Density | 1.3952 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | -20°C |
| form | Crystalline Powder |
| color | White to off-white |
| Water Solubility | almost transparency |
| Sensitive | Hygroscopic |
| BRN | 6098010 |
| FDA UNII | M73AI9718D |
| ATC code | V04CX03 |
| EPA Substance Registry System | 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
METHACHOLINE BROMIDE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2126 | Acetyl-β-methylcholine bromide ≥99% | 333-31-3 | 100g | $204.4 | 2024-03-01 | Buy |
| TCI Chemical | M0072 | Methacholine Bromide >99.0%(T) | 333-31-3 | 25g | $106 | 2024-03-01 | Buy |
| TCI Chemical | M0072 | Methacholine Bromide >99.0%(T) | 333-31-3 | 100g | $318 | 2024-03-01 | Buy |
| TRC | A186630 | Acetyl-β-methylcholine bromide | 333-31-3 | 10g | $305 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001361 | ACETYL-BETA-METHYL CHOLINE BROMIDE 95.00% | 333-31-3 | 25G | $1202.74 | 2021-12-16 | Buy |
METHACHOLINE BROMIDE Chemical Properties,Uses,Production
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
Methacholine is used only for bronchial hyperreactivity diagnostics. A synonym of this drug is provocholine.
Uses
Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.
General Description
Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.
Mechanism of action
A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.
Synthesis
Methacholine, 1-acetoxy-2-(N,N,N-trimethyl)propyl ammonium chloride (13.1.4) or acetyl-β-methylcholine can be synthesized by any of the methods described above [8]
METHACHOLINE BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
METHACHOLINE BROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18458 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from METHACHOLINE BROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | METHACHOLINE BROMIDE
333-31-3
|
US $1.00 / g | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- METHACHOLINE BROMIDE
333-31-3
- US $1.00 / g
- 99.0%
- Career Henan Chemical Co