GNF1331
- CAS No.
- 603101-22-0
- Chemical Name:
- GNF1331
- Synonyms
- GNF1331;GNF-1331 >=98% (HPLC);Acetamide, N-(6-methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-
- CBNumber:
- CB74919697
- Molecular Formula:
- C20H20N6O2S2
- Molecular Weight:
- 440.54
- MDL Number:
- MFCD03750964
- MOL File:
- 603101-22-0.mol
GNF1331 Chemical Properties,Uses,Production
Description
GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.
in vivo
GNF-1331 shows good potency in the Wnt secretion coculture assay with an IC50 of 12 nM. It binds to PORCN in a radioligand binding assay with an IC50 of 8 nM. However, it exhibits poor pharmacokinetic properties with rapid clearance and low systemic exposure after oral administration in mice (dose normalized Cmax and AUC are 0.03 μM·h and 0.014 μM, respectively), which prevent it from being used in vivo._x000D_ _x000D_ Reference: ACS Med Chem Lett. 2016 May 10;7(7):676-80. https://pubmed.ncbi.nlm.nih.gov/27437076/
target
GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM).
GNF1331 Preparation Products And Raw materials
Raw materials
Preparation Products
GNF1331 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |