GO 6983
- CAS No.
- 133053-19-7
- Chemical Name:
- GO 6983
- Synonyms
- CS-674;gǒ 6983;Gδ 6983;GOE 6983;Go6983(96 %);GO6983 GO-6983;GO 6983 USP/EP/BP;G 6983 - GO 6983 | Goe 6983;GOE 6983;GO6983 GO-6983;GO 6983;G 6983 - CAS 133053-19-7 - Calbiochem
- CBNumber:
- CB7498134
- Molecular Formula:
- C26H26N4O3
- Molecular Weight:
- 442.51
- MDL Number:
- MFCD04040031
- MOL File:
- 133053-19-7.mol
- MSDS File:
- SDS
| Boiling point | 709.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, clear, red |
| form | powder |
| pka | 8.02±0.60(Predicted) |
| color | red |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
GO 6983 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G1918 | Gö 6983 ≥97% | 133053-19-7 | 500μg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | G1918 | G 6983 ≥97% | 133053-19-7 | 1mg | $223 | 2024-03-01 | Buy |
| Sigma-Aldrich | 365251 | Gö 6983 - CAS 133053-19-7 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes. | 133053-19-7 | 500μg | $172 | 2024-03-01 | Buy |
| Alfa Aesar | J67008 | G? 6983, 98% | 133053-19-7 | 1mg | $94.5 | 2023-06-20 | Buy |
| Alfa Aesar | J67008 | G? 6983, 98% | 133053-19-7 | 5mg | $259 | 2021-12-16 | Buy |
GO 6983 Chemical Properties,Uses,Production
Description
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4
Uses
Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor
Uses
GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).
Definition
ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Biochem/physiol Actions
Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
storage
-20°C
References
1) Gschwendt et al. (1996), Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes; FEBS Lett., 392 77 2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16 3) Rajendran et al. (2013), Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351 4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255
GO 6983 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29576 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
