SB-505124
- CAS No.
- 356559-13-2
- Chemical Name:
- SB-505124
- Synonyms
- SB-505124 HCl;SB-505124 hydrochloride;TGF-β RI Kinase Inhibitor III;TGF-β RI Kinase Inhibitor III;TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem;Pyridine, 2-[5-(1,3-benzodioxol-5-yl)-2-(1,1-diMethylethyl)-1H-iMidazol-4-yl]-6-Methyl-, Monohydrochloride
- CBNumber:
- CB7498396
- Molecular Formula:
- C20H22ClN3O2
- Molecular Weight:
- 371.87
- MDL Number:
- MOL File:
- 356559-13-2.mol
SB-505124 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 616453 | TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem | 356559-13-2 | 2mg | $216 | 2024-03-01 | Buy |
| TRC | T338003 | TGF-betaRIKinaseInhibitorIII | 356559-13-2 | 2mg | $175 | 2021-12-16 | Buy |
| TRC | T338003 | TGF-betaRIKinaseInhibitorIII | 356559-13-2 | 4mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | A3799 | SB-505124hydrochloride | 356559-13-2 | 50mg | $410 | 2021-12-16 | Buy |
| Crysdot | CD31002125 | SB-505124hydrochloride 98+% | 356559-13-2 | 10mg | $78 | 2021-12-16 | Buy |
SB-505124 Chemical Properties,Uses,Production
Uses
TGF-beta RI Kinase Inhibitor III is an inhibitor of activin receptor-like kinase 4.
Biological Activity
sb505124 is a selective inhibitor of tgfβr for alk4, alk5 with ic50 value of 129 nm and 47 nm [1].anaplastic lymphoma kinase (alk) gets involved in the development of the brain and influence specific neurons in the nervous system.sb505124 is a reversible atp competitive inhibitor of alk4 and alk5. incubation of the alk5 with high concentrations of sb505124, followed by dilution to a sub-ic50 concentration resulted in no effect of downstream smad3 phosphorylation [2]. sb505124 was shown to have no toxicity to renal epithelial a498 cells at concentrations up to 100 μm for 48 h. evidence showed that 100% drug will release within 12 h, and the gel showed no cytotoxicity to the cultured rabbit subconjunctival cells[2]. it was observed that alk4 downstream effectors including psmad2, ctgf, and α-sma was inhibited by sb505124 in cultured fibroblasts [3].in rabbit in glaucoma filtration surgery (gfs) model, the period of filtering blebs were reduced by tgfβ induced fibroblast. the filtering blebs in the gfs with sb505124 group were maintained for more than 10 days, and the period of bleb survival was significantly longer than that in controls, which suggested the significant inhibition of alk4 and 5 by sb505124 [2]. it was observed that alk4 downstream effectors ctgf and α-sma were suppressed by sb-505124 in vivo[3].
References
[1]. dacosta b s et al. sb-505124 is a selective inhibitor of transforming growth factor-beta type i receptors alk4, alk5, and alk7. mol pharmacol., 2004,65(3): 744-52.
[2]. sutariya v, et al. thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor sb-505124 for glaucoma filtration surgery. pharm dev technol., 2013, 18(4): 957-962.
[3]. sapitro j, et al. suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. mol vis., 2010, 16: 1880-1892.
SB-505124 Preparation Products And Raw materials
Raw materials
Preparation Products
SB-505124 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Shanghai Taifu Pharmaceutical Technology Co. LTD | 021-58111238 18930958102 | sales@taifupharm.com | China | 509 | 55 |
| Suzhou yacoo science co.,Ltd | 0512-87182056 18013166090 | lingling.qi@yacoo.com.cn | China | 7300 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Aikon International Limited | 025-66113011 13155353615 | qzhang@aikonchem.com | China | 15396 | 58 |