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DL-Menthol

Flavors and fragrances First aid of poisoning Detection method Chemical properties Uses
DL-Menthol
DL-Menthol structure
CAS No.
89-78-1
Chemical Name:
DL-Menthol
Synonyms
89-78-1;I-menthol;DL - mint;DL-Menthol;MENTHOL 99;MENTHOL(RG);MENTHOL 99%;dl-Peppermint;Menthacamphor;Menthomenthol
CBNumber:
CB7498497
Molecular Formula:
C10H20O
Formula Weight:
156.27
MOL File:
89-78-1.mol

DL-Menthol Properties

Melting point:
34-36 °C(lit.)
Boiling point:
216 °C(lit.)
alpha 
-2 º (c=10, EtOH)
Density 
0.89 g/mL at 25 °C(lit.)
vapor pressure 
0.8 mm Hg ( 20 °C)
refractive index 
1.4615
FEMA 
2665 | MENTHOL RACEMIC
Flash point:
200 °F
storage temp. 
Store below +30°C.
solubility 
456mg/l
form 
Crystalline Solid
color 
Colorless to white
Water Solubility 
insoluble
Merck 
14,5837
JECFA Number
427
BRN 
3194263
CAS DataBase Reference
89-78-1(CAS DataBase Reference)
NIST Chemistry Reference
DL-Menthol(89-78-1)
EPA Substance Registry System
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-(89-78-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  37/38-41-36/37/38
Safety Statements  36/37/39-24/25-36-26-39
RIDADR  UN 1888 6.1/PG 3
WGK Germany  2
RTECS  OT0350000
Autoignition Temperature 405 °C
TSCA  Yes
HS Code  29061100
Hazardous Substances Data 89-78-1(Hazardous Substances Data)
Toxicity LD50 orally in rats: 3180 mg/kg (Jenner)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

DL-Menthol price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 63670 (±)-Menthol racemic, ≥98.0% (GC) 89-78-1 100g-f $35.4 2018-11-13 Buy
Sigma-Aldrich 05174 DL-Menthol analytical standard 89-78-1 100mg $59.7 2018-11-22 Buy
TCI Chemical M0321 (+/-)-Menthol >98.0%(GC) 89-78-1 25mL $14 2018-11-22 Buy
TCI Chemical M0321 (+/-)-Menthol >98.0%(GC) 89-78-1 100mL $36 2018-11-22 Buy
Alfa Aesar A18098 DL-Menthol, 98+% 89-78-1 100g $36.9 2018-11-13 Buy

DL-Menthol Chemical Properties,Uses,Production

Flavors and fragrances

Menthol is a cyclic terpene alcohol flavors and fragrances with its appearance exhibiting colorless needle or shuttle columnar crystal or white crystalline powder. It has special aroma of mint with its taste being hot at first but then being cool later. It exhibit neutralizing reaction in the ethanol solution, being extremely easily soluble in ethanol, chloroform, petroleum ether, ether, liquid paraffin or volatile oil and being very slightly soluble in water.
Its molecular structure contains three asymmetric carbon atoms, so it has four stereoisomers with their aroma intensity and type and cool feeling being different. There are two common types: natural menthol and synthetic menthol. Natural menthol is a kind of saturated ring alcohol obtained through the freezing & crystallization, separation and refinement of peppermint oil with the optical rotation being L; synthetic menthol is made from taking lemon eucalyptus oil as raw material.
Its main component can be manufactured from the ring closing reaction of citronellal to obtain isopulegol, followed by hydrogenation, or through the synthesis of thymol from m-cresol with catalytic hydrogenation resulting in four menthol mixture of isomers with the precise vacuum distillation obtaining defined synthetic menthol, being racemate with no optical rotation. It has bactericidal and anti-corrosion effect and can be used as the fragrance of toothpaste, perfume, beverages and confectionery. In the medicine, it can be used for making cool oil, painkillers, mouthwash, and so on.
The main applications are as follows:
1. Menthol can act on the skin sensory nerve end, making the skin surface to produce cool feeling, achieving the purpose of itching prevention. Topical administration to the affected area can be used for the treatment of urticaria, prurigo, prickly heat, rash, neurodermatitis and skin pruritus and so on.
2. It can be used for the treatment of headache, nasal congestion and sore throat. This product has pleasant aroma and has curing effect on treating cold and wind heat. It has effects of refreshing the mind and clearing the throat.

First aid of poisoning

Topical application of menthol have effects of promoting blood circulation and anti-inflammatory, anti-itching and can be applied to anti-inflammatory, antipruritic, analgesic and reducing swelling and so on.
【Diagnosis】
1. Oral administration of large amount of menthol or inhaling of large amount of menthol gas can lead to gastrointestinal symptoms such as nausea, vomiting and abdominal pain as well as nervous system symptoms such as excitement, tremor, dizziness, vertigo, hand and foot numbness, swing gait, lethargy, breathing changes, facial flushing, reduced blood pressure, muscle rigidity or relaxation, occasional being not able to speak; children, after taking a large dose, can have coma. But it can be generally restored within a few hours.
2. Patients allergic to this chemical can get with eczema with unbearable itching feeling.
3. Small infants, sometimes due to nasal mint liquid or ointment, can get glottis spasm, accompanied with bruising and suffocation as well as secretion of large amounts of mucus. In severe cases, it may be occurred of respiratory and cardiac arrest.
【Treatment principles】
1. Gastric lavage; conduct catharsis with salt cathartic. Avoid using fats and oils.
2. Apply intravenous rehydration to promote excretion.
3. In cases of allergic symptoms, we should treat with antihistamines such as diphenhydramine, chlorpheniramine, etc.; if necessary, we can apply hydrocortisone or dexamethasone intravenously.

Detection method

(1) Chemical qualitative method
① take 1 g of this product, add 20 mL of sulfuric acid to dissolve it, so the reaction mixture becomes orange-red. After 24h, there will be colorless oil layer of non-menthol aroma precipitated out (the distinction from thymol).
② take 50 mg of this product, add 1mL of ice acetic acid to dissolve it; Addition of 6 drops of sulfuric acid and 1 drop of nitric acid to the cold mixture will lead to only slightly yellow color (the difference from thymol).
(2) thin-layer chromatography: take appropriate amount of menthol and dissolve in anhydrous ethanol, make a solution containing 6 mg menthol per mL for spotting. TLC: silica gel G manual plating, make it dry; have it subjected to activation in 105 °C for 1 hour and standby. Developing agent A: n-hexane-ethyl acetate-benzene (43: 4.5: 4); Developing agent B: petroleum-ether-ethyl acetate-chloroform (25: 2.5: 5.5). Coloration reagent: 5% vanillin ethanol solution-concentrated sulfuric acid (100: 6). Coloration: heating at 105 ℃ for 6~10min, exhibiting a circular blue spots.
(3) Determination of physical constants: melting point: 42 ℃~44 °C. Specific rotation: take this product for accurately weighing; add ethanol to make a solution of 0.1 g/mL. Measure according to the method, the specific rotation is-49 ° ~-50 °.
(4) non-volatile matter: take 2 g of this product and place it in the pre-weighed evaporating dish; have it heated in the water bath so it is slowly evaporated; dried at 105 ℃ to constant weight with the leftover residue not exceeding 1mg.

Chemical properties

L-form appears as colorless needle crystal. The melting point is 42-43 °C; the boiling point is 216 °C, the specific rotation:-51 °-45 °; the flash point: 93 °C; the relative density: 0.8810; it is soluble in ethanol and is miscible with oil. It has cool, fresh, pleasant mint characteristic aroma with sweet spiky gas. It gives people a cold feeling with aroma penetrating through the hair, but not lasting. The taste is also fresh sweet cool taste.

Uses

It is mainly used in medicine, toothpaste, toothpaste and mouthwash with its cool taste being able to enhance the smell of peppermint oil, having effect of refreshing the brain as well as disinfection effects. It can also be used as spices to be applied to the colognes. Application of appropriate amount of low-grade soap and detergent fragrance such as roses, geraniol, lavender and fragrant has effects of enhancing the tone and aroma. It can also be applied to food flavors and flavor for wine and tobacco.
In medicine, it can be applied to the cooling oil, painkillers, etc., it can also be used for making toothpaste, toothpowder, candy, beverages, spices and so on. How to use: it can be used for formulating the food flavor in the food flavor plant; or also be directly added or dissolved in alcohol to be added to the food flavoring. Storage requirements: placed in a cool place, sealed for storage. Avoid wind and rain.

Chemical Properties

colorless to white crystalline solid

Uses

A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

Uses

In liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers.

General Description

White crystalline solid with a peppermint odor and taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.

Hazard

Irritant to mucous membranes on inhalation.

Fire Hazard

DL-Menthol is combustible.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A severe eye irritant. Incompatible with phenol, p-naphthol, resorcinol or thymol in trituration, potassium permanganate, chromium trioxide, pyrogallol. Combustible liquid. \When heated to decomposition it emits acrid smoke and irritating fumes.

DL-Menthol Preparation Products And Raw materials

Raw materials

Preparation Products


DL-Menthol Suppliers

Global( 267)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19947 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3210 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1737 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20177 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4696 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 749 58

View Lastest Price from DL-Menthol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 DL-Menthol
89-78-1
US $1.00 / kg 1 g 99% 100KG career henan chemical co
2018-09-19 Menthol
89-78-1
US $20.00 / KG 10G 99% 20 MT Hebei Huanhao Biotechnology Co., Ltd.
2018-09-12 DL - mint
89-78-1
US $1.00 / G 100G 99.9% 50000tons Hebei Ruishun Trade Co.,Ltd

DL-Menthol Spectrum


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