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Paraquat

Description References
Paraquat
Paraquat structure
CAS No.
4685-14-7
Chemical Name:
Paraquat
Synonyms
Pectone;Prelude;Paraquat;Pillarzone;Grammoxone;Paraquat ion;Orthoparaquat;Paraquat aqueous;Dimethylviologen;20% PARAQUAT AQUA
CBNumber:
CB7512162
Molecular Formula:
C12H14N2+2
Formula Weight:
186.25
MOL File:
4685-14-7.mol

Paraquat Properties

Melting point:
300 °C (decomp)
Boiling point:
310.75°C (rough estimate)
Density 
0.9748 (rough estimate)
refractive index 
1.5600 (estimate)
form 
Yellow solid
color 
Off-white Powder
color 
Colorless hygroscopic crystals or white to yellow hygroscopic crystalline powder
EWG's Food Scores
1
FDA UNII
PLG39H7695
EPA Substance Registry System
Paraquat (4685-14-7)
SAFETY
  • Risk and Safety Statements
Hazard Codes  T
Risk Statements  26/27/28
Safety Statements  1-13-45
RIDADR  2781
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 orl-rat: 150 mg/kg FMCHA2 -,C118,83
Toxicity LD50 orl-rat: 100 mg/kg IYKEDH 10,520,79
NFPA 704
0
4 0

Paraquat Chemical Properties,Uses,Production

Description

Paraquat is classified as quick-acting and non-selective herbicide, which is one of the most widely used herbicides all over the world. It is widely applied in agriculture to control a exceedingly wide range of annual grasses, broad-leaved weeds and established perennial weeds on contact, which can benefit more than a hundred crops, including cereals, oil seeds, fruit and vegetables, growing in all climates. It can be photochemically decomposed by irradiation of ultraviolet rays in aqueous solutions and is rapidly inactivated by soil. As a chemical weed killer, the outstanding properties of paraquat distinguish itself from other agents applied in plant protection products.  

References

https://en.wikipedia.org/wiki/Paraquat
https://pubchem.ncbi.nlm.nih.gov/compound/15939#section=Reactive-Group
http://www.toxipedia.org/display/toxipedia/Paraquat
http://paraquat.com/knowledge-bank/paraquat-fact-sheet

Description

Paraquat is a quaternary ammonium compound with herbicide properties, as diquat. It is contained in Cekuquat or Dipril.

Chemical Properties

Paraquat is a yellow solid with a faint, ammonia-like odor.

Uses

It can cause contact and phototoxic contact dermatitis, acne, and leucoderma, mainly in agrieultural workers.

Uses

Herbicide

Production Methods

Paraquat is produced in several countries by coupling pyridine in the presence of sodium in anhydrous ammonia and quaternizing the resulting 4,4-bipyridyl with methyl chloride. The only impurity permitted is the 4,40-bipyridyl at a maximum level of 0.25% of the paraquat content. It is formulated for commercial use in various concentrations and mixtures. In the United States, paraquat is sold in watersoluble concentrates at 1.5–2.5 lb/gal.

Preparation

Paraquat is synthesized by the direct quaternization of 4,4 -bipyridyl with chloromethane under pressure (1,9). Diquat is synthesized by reaction of 2,2 -bipridyl with di-n-propyl amine.

Definition

ChEBI: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.

Health Hazard

Paraquat salts show moderate to high acutetoxicity among species, the oral LD50 values ranging between 25 and 300 mg/kg.The LD50 values in dogs, cats, guinea pigs,and rats are 25, 35, 30, and 100 mg/kg,respectively, for the sulfate salts. The toxicsymptoms from ingestion and inhalationof dusts include headache, nausea, vomiting, diarrhea, ulceration, dyspnea, and lunginjury. Single exposure to paraquat aerosols 3–5 mm in diameter at 1 mg/m3 concentration for 6 hours caused death to rats (ACGIH 1986). Inhalation of nonrespirable size dustscaused intense irritation and nose bleeding.Repeated exposures can lead to severe pulmonary edema and fibrosis. The dusts are anirritant to the respiratory tract.
Dey and associates (1990) investigatedparaquat pharmacokinetics in rats, using asubcutaneous toxic low dose (72 mmol/kg)of [14CH3] paraquat, which would producelung disease but no renal damage. Paraquatwas rapidly absorbed. Peak blood concentrations were 58 nmol/mL at 20 minutes,while its peak concentrations in the lungand kidney were 65 and 359 nmol/g, respectively, at 40 minutes. About 85% of dosewas eliminated in the urine by 7 days. Of theremaining radioactivity, 79% remained in thebody and 21% remained in the lung, causing progressive lung disease. Excretion ofthe retained amount was slow and prolonged.Chui and coworkers (1988) investigated thetoxicokinetics of paraquat and the effects ofdifferent routes of administration. A singledose of 11.4 mg/kg of [14CH3 ]paraquat wasadministered in rats by intravenous, intragastric, dermal, and pulmonary (exposure byaqueous or liquid aerosols) routes. The majorexcretion routes were urine and feces.
The radioactivity absorbed into thesystemic circulation of the rat was about27.5, 23.8, 8.5, and 1.5 nmol for inhalationthrough a tracheal cannula, nose-only expo-sure, intragastric injection, and dermalabsorption, respectively. The bulk of theherbicide administered by the inhalation anddermal routes remained at the sites of theadministration.
In humans, cardiovascular collapse result-ing from acute paraquat poisoning is asso-ciated with the distribution phase; the lateoccurrence of death-related pulmonary fibro-sis is associated with the elimination phase(Houze et al. 1990). Toxicokinetics studiesconducted by these investigators in acutehuman poisoning cases indicated a concen-tration of paraquat in blood that had a mean distribution half-life of 5 hours and a meaneliminationhalf-lifeof84 hours,respectively.It was excreted in the urine. It was retainedin the muscle for several weeks after poi-soning. Electron microscopy studies (TEMand SEM) on the lungs obtained from adog after 7 days of intravenous administra-tion of paraquat (12 mg/kg) indicate detach-ment of alveolar epithelial cells and alve-olar macrophage, which plays a significantrole in paraquat-induced pulmonary fibrosis(Hampson and Pond 1988). Administrationof paraquat to adult rat pulmonary alveolarmacrophages in primary culture caused celldeaththatwasdependentonthedoseandtime.The cell death was potentiated by hyperoxia(95% O) and extracellular production of anactive oxygen species, the superoxide anionradical (Wong and Stevens 1985). Althoughdiquat can enter the cells to a greater extent,than can paraquat, the latter is about twice aspotent as diquat (Wong and Stevens 1986).
Paraquat is a urinary metabolite of 4,48-bipyridyl when the latter is administeredintraperitoneally to guinea pigs. Godin andCrooks (1989) detected 2.9% N-methyl-4,48-bipyridinium ion in the urine of animalstreated with 4,48-bipyridyl, thus indicat-ing the formation of such toxic metabolitesthrough the N-methylation pathway.
Certain substances have been reported topotentiate the toxicity of paraquat. Theseinclude transition metal ions such as copper(Kohen and Chevion 1985) and ethanol (Kuoand Nanikawa 1990). Blood paraquat lev-els showed significant elevation in rabbits,and the mortality rates increased when theanimals were orally administered paraquatcombined with ethanol in amounts of 2.0and 3.8 g/kg. Continuous breathing of highoxygen concentrations 12–24 hours afteradministration of paraquat caused severe andextensive pulmonary lesions and interstitialfibrosis (Selman et al. 1985). On the otherhand, a reverse sequence of treatment—inhalation of high oxygen concentrations followed by paraquat administration—causedno mortality and pulmonary lesions.
The effect of light on toxicity of paraquathas been reported (Barabas et al. 1986). A72-hour exposure to illumination increasedthe lethality of paraquat in mice. Changesin the activity of the enzymes, catalase, superoxide dismutase, and glutathione peroxidase,were also noted after exposure to light.
Antidote actions of a few substancesagainst paraquat toxicity have been reported.These include several sodium sugar sulfates,including dextran sulfate, cellulose sulfate,chondroitin sulfate, sucrose sulfate, and glu-cose sulfate (Tsuchiya et al. 1989; Ukai et al.1987). Sugar sulfates 2000 mg/kg, givenorally immediately after paraquat ingestion (200 mg/kg), protected mice againstthe acute toxicity of the herbicide. Thiols,cystein, d-penicillamine, and GSH were found to protect mice against a LD50 dose of paraquat(Szabo et al. 1986). The protecting actionof these compounds decreased in the ordernoted above.

Agricultural Uses

Herbicide, Defoliant, Desiccant: Paraquat is a quaternary nitrogen herbicide widely used for broadleaf weed control. It is a quick-acting, nonselective compound, that destroys green plant tissue on contact and by translocation within the plant. It has been employed for killing marijuana in the U.S. and in Mexico. It is also used as a crop desiccant and defoliant, and as an aquatic herbicide. It is used in many formulations with other herbicides, e. g., simazine and diquat. Paraquat dichloride is registered for the control of weeds and grasses in agricultural and non-agricultural areas. It is used as a preplant or pre-emergence herbicide on vegetables, grains, cotton, grasses, sugarcane, peanuts, potatoes, and on areas for tree plantation establishment. Paraquat is applied as a directed spray post-emergence herbicide around fruit crops, vegetables, trees, vines, grains, soybeans, and sugarcane. It is used for dormant season applications on clover and other legumes, and for chemical fallow. It is also used as a desiccant or harvest aid on cotton, dry beans, soybeans, potatoes, sunflowers, sugarcane and as a post-harvest desiccant on tomatoes. It is applied to pine trees to induce resin soaking. Paraquat dichloride is also used on non-crop areas such as public airports, electric transformer stations and around commercial buildings to control weeds. Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP).

Trade name

HERBICIDE®[C]; CRISQUAT®; CYCLONE®; DEXTRONE®; DEXTRONE-X®; ESGRAM®; GAMIXEL®; GOLDQUAT 276®; GRAMOXONE®; GRAMOXONE D®; GRAMOXONE DICHLORIDE®; GRAMOXONE S®; GRAMOXONE W®; HERBIKILL®; HERBOXONE®; OK 622®; ORTHO PARAQUAT CL®[C]; PARA-COL®; PARAMINE®; PARAQUAT CL®[C]; PARAQUAT DICHLORIDE BIPYRIDYLNIUM HERBICIDE®; PATHCLEAR®; PILLARQUAT®; PILLARXONE®; PP148®; PRELUDE®[C]; STARFIRE®; SUREFIRE®; SWEEP®; TERRAKLENE®; TOTACOL®; TOXER TOTAL®; UNIQUAT®; WEEDOL®

Contact allergens

Paraquat is a quaternary ammonium compound with herbicide properties, as diquat. It is contained in Cekuquat? or Dipril?. It can cause contact and phototoxic contact dermatitis, acne, and leukoderma mainly in agricultural workers.

Safety Profile

Poison by ingestion and intraperitoneal routes. Mutation data reported. Human systemic effects: changes in structure or function of esophagus, darrhea, edema, fibrosis of lung, fibrosis, focal (pneumoconiosis), hemorrhage, jaundice, renal damage, renal function tests depressed, respiratory depression, ulceration or bleedmg from stomach, vomiting. Death from anoxia may result. When heated to decomposition it emits toxic fumes of NOx. See also PARAQUAT DICHLOFUDE

Potential Exposure

Those engaged in manufacture, formulation and application of this herbicide. Classified for restricted use: limited to use by a certified applicator, or those under applicator’s direct supervision.

Carcinogenicity

Several carcinogenicity studies have been conducted on paraquat by the oral route. In a 2-year feeding study at doses as high as 75 mg/kg in mice, and a drinking water study at doses as high as 2.6 mg/L of water in rats, no evidence of tumorigenicity was seen. Similar negative results were reported for diquat in a 2-year feeding study (Hayes, 1991) in rats at dose levels up to 720 mg/kg and in a 2-year drinking water study in mice at doses of 2–4 mg/kg.

Metabolism

Because paraquat and diquat are positively charged ions, they are very quickly and tightly bound to negatively charged clay particles in the soil, rendering them totally inactive (1). Thus, these herbicides have no soil activity.
Plants do not actively metabolize either paraquat or diquat (31); however, substantial photodegradation does occur on the leaf surface. Isonicotinic acid and methylamine hydrochloride are the decomposition products most often noted from paraquat (1). With diquat, the decomposition products included the pyrazinium salt, picolinamide, and picolinic acid (1). Photodegradation of diquat was greater than that of paraquat at equal irradiances (1–3).

Shipping

UN2781 Bipyridilium pesticide, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Toxicity evaluation

Paraquat is most active in rapidly respiring tissue and in the presence of oxygen, it is not surprising that most of the damage in mammalian systems is associated with lung tissue. Symptoms such as fibrosis and hemorrhage of the lungs are often detected after paraquat poisoning.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides (hydrolysis), alkylarylsulfonate wetting agents. Corrosive to metals. Decomposes in presence of ultraviolet (UV) light. Decomposes in heat (see physical properties, above) and in the presence of UV light, producing nitrogen oxides, hydrogen chloride.

Waste Disposal

Paraquat is rapidly inactivated in soil. It is also inactivated by anionic surfactants. Therefore an effective and environmentally safe disposal method would be to mix the product with ordinary household detergent and bury the mixture in clay soil. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Paraquat Preparation Products And Raw materials

Raw materials

Preparation Products


Paraquat Suppliers

Global( 85)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58

View Lastest Price from Paraquat manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 Paraquat
4685-14-7
US $1.53 / g 10g 99.9% 200MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-08-31 paraquat
4685-14-7
US $50.00 / KG 1Kg/Bag 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2019-07-06 Paraquat
4685-14-7
US $1.00 / kg 1g 99% 100KG career henan chemical co

Paraquat Spectrum


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