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CDK4/6-IN-2

CDK4/6-IN-2 Structure
CDK4/6-IN-2 structure
CAS No.
1800506-48-2
Chemical Name:
CDK4/6-IN-2
Synonyms
AM24679P4;CDK4/6-IN-2;CDK4/6 inhibitor 2;Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor;5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine;2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-
CBNumber:
CB75419703
Molecular Formula:
C27H32F2N8
Molecular Weight:
506.59
MDL Number:
MFCD32067908
MOL File:
1800506-48-2.mol
Last updated:2023-09-20 16:43:00
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CDK4/6-IN-2 Properties

Boiling point 665.2±65.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 5.2 mg/mL (10.26 mM)
pka 7.67±0.10(Predicted)

CDK4/6-IN-2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0083151 CDK4/6-IN-2 99.82% 1800506-48-2 5mg $350 2021-12-16 Buy
ChemScene CS-0083151 CDK4/6-IN-2 99.82% 1800506-48-2 10mg $550 2021-12-16 Buy
ChemScene CS-0083151 CDK4/6-IN-2 99.82% 1800506-48-2 50mg $1650 2021-12-16 Buy
ChemScene CS-0083151 CDK4/6-IN-2 99.82% 1800506-48-2 100mg $2650 2021-12-16 Buy
Product number Packaging Price Buy
CS-0083151 5mg $350 Buy
CS-0083151 10mg $550 Buy
CS-0083151 50mg $1650 Buy
CS-0083151 100mg $2650 Buy

CDK4/6-IN-2 Chemical Properties,Uses,Production

Description

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. CDK4|2.7 nM (IC50)|CDK6|16 nM (IC50)

CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1].

References

[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.

CDK4/6-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

CDK4/6-IN-2 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 595 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 9946 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5019 58
RD International Technology Co., Limited 18988968278 sales@ubiochem.com China 9146 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Kaixin Chemical (Hong Kong) Limited 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
cjbscvictory 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58

CDK4/6-IN-2 Spectrum

CDK4/6-IN-2(1800506-48-2)1HNMR
CDK4/6-IN-2 CDK4/6 inhibitor 2 5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine AM24679P4 Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor 2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]- 1800506-48-2 CHFN