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N-(Trimethylsilyl)acetamide

N-(Trimethylsilyl)acetamide structure

CAS No.: 13435-12-6

Chemical Name:: N-(Trimethylsilyl)acetamide

Synonyms: TMSA;DK063;TMS ACETAMIDE;trimethylsilyl;N-TMS-acetamide;N-(Trimethylsilyl);TRIMETHYLSILYLACETAMIDE;N-TRIMETHYLSILYLACETAMIDE;n-(trimethylsilyl)-acetamid;(acetylamino)trimethylsilane

CBNumber:: CB7667530

Molecular Formula:: C5H13NOSi

Molecular Weight:: 131.25

MDL Number:: MFCD00008671

MOL File:: 13435-12-6.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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N-(Trimethylsilyl)acetamide Properties

Melting point	46-49 °C(lit.)
Boiling point	84 °C18 mm Hg(lit.)
Density	0.859±0.06 g/cm3(Predicted)
Flash point	135 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, DMSO, Methanol
pka	18.23±0.46(Predicted)
form	Crystalline Mass
color	White to yellow
Water Solubility	reacts
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	741928
Stability	Moisture Sensitive
CAS DataBase Reference	13435-12-6(CAS DataBase Reference)
EWG's Food Scores	1
EPA Substance Registry System	Acetamide, N-(trimethylsilyl)- (13435-12-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P302+P352-P305+P351+P338

Hazard Codes

Xi-F,Xi,F

Risk Statements

36/37/38-11

Safety Statements

37/39-26

RIDADR

1325

WGK Germany

RTECS

AD0250000

10-21

TSCA

Yes

HazardClass

4.1

PackingGroup

III

HS Code

29319090

NFPA 704

	2
1		0

N-(Trimethylsilyl)acetamide price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	223298	N-(Trimethylsilyl)acetamide 95%	13435-12-6	25g	$124	2024-03-01	Buy
TCI Chemical	T0590	N-Trimethylsilylacetamide >98.0%(GC)	13435-12-6	25g	$118	2024-03-01	Buy
TRC	T796720	N-Trimethylsilylacetamide	13435-12-6	25g	$60	2021-12-16	Buy
Usbiological	468234	Trimethylsilyl	13435-12-6	10g	$319	2021-12-16	Buy
Medical Isotopes, Inc.	42527	N-Trimethylsilylacetamide	13435-12-6	50g	$640	2021-12-16	Buy

Product number	Packaging	Price	Buy
223298	25g	$124	Buy
T0590	25g	$118	Buy
T796720	25g	$60	Buy
468234	10g	$319	Buy
42527	50g	$640	Buy

N-(Trimethylsilyl)acetamide Chemical Properties,Uses,Production

Chemical Properties

WHITE TO YELLOWISH CRYSTALLINE MASS

Uses

N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

General Description

The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.

Purification Methods

Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

N-(Trimethylsilyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Cefdinir 2-METHYL-1-(TRIMETHYLSILOXY)-1-PROPENE 1-(Trimethylsiloxy)cyclopentene Allylisopropylacetamide

N-(Trimethylsilyl)acetamide Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hubei Co-Formula Material Tech Co., Ltd.	+86-27-84459282	sales@cfmats.com	CHINA	882	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Win-Win Chemical CO., Limited	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hubei Co-Formula Material Tech Co., Ltd.	58
Fuxin Pharmaceutical	58

View Lastest Price from N-(Trimethylsilyl)acetamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-09-28	N-(Trimethylsilyl)acetamide 13435-12-6	US $0.00-0.00 / g	10g	100%	10kg	Zhengzhou Gecko Scientific Inc.
2021-07-13	N-(Trimethylsilyl)acetamide 13435-12-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	N-(Trimethylsilyl)acetamide 13435-12-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

N-(Trimethylsilyl)acetamide
13435-12-6
US $0.00-0.00 / g
100%
Zhengzhou Gecko Scientific Inc.

N-(Trimethylsilyl)acetamide
13435-12-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-(Trimethylsilyl)acetamide
13435-12-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-(Trimethylsilyl)acetamide Spectrum

N-(Trimethylsilyl)acetamide(13435-12-6)¹HNMR N-(Trimethylsilyl)acetamide(13435-12-6)IR1 N-(Trimethylsilyl)acetamide(13435-12-6)IR2 N-(Trimethylsilyl)acetamide(13435-12-6)Raman

13435-12-6(N-(Trimethylsilyl)acetamide)Related Search:

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N-(TRIMETHYLSILYL)ACETAMIDE FOR SYNTHESI N-(Trimethylsilyl)acetamide,97% N-(Trimethylsilyl) (acetylamino)trimethylsilane n-(trimethylsilyl)-acetamid N-TRIMETHYLSILYLACETAMIDE TRIMETHYLSILYLACETAMIDE TMSA TMS ACETAMIDE N-TrimethylsilylacetamideA.R. trimethylsilyl N-TRIMETHYLSILYL ACETAMIDE(TMSA) N-TMS-acetamide Acetamide, N-(trimethylsilyl)- N-Trimethylsilylacetamide > 13435-12-6 N-(Trimethylsilyl)acetamide DK063 13435-12-6 C5H13NOSi CH3CONHSiCH33 Derivatization Reagents Fluka Reagents Organic Building Blocks Si (Classes of Silicon Compounds) Silylation (GC Derivatizing Reagents) Silylacetamides Acyclic Alkenes Analytical Chromatography Product Catalog Building Blocks Trimethylsilylation (GC Derivatizing Reagents) Si-N Compounds GC Derivatizing Reagents Silicon Compounds (for Synthesis) Aliphatics Miscellaneous Reagents Analytical Chemistry GC Derivatizing Reagents Si (Classes of Silicon Compounds) Silicon Compounds (for Synthesis) Silylacetamides Silylation (GC Derivatizing Reagents) Si-N Compounds Synthetic Organic Chemistry Trimethylsilylation (GC Derivatizing Reagents)