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NITROUS OXIDE

NITROUS OXIDE
NITROUS OXIDE
CAS No.
10024-97-2
Chemical Name:
NITROUS OXIDE
Synonyms
n20;N2O;Nitral;Lachgas;stickdioxyd;oxydenitreux;oxidonitroso;nitros oxide;LAUGHING GAS;factitiousair
CBNumber:
CB7676965
Molecular Formula:
N2O
Formula Weight:
44.01
MOL File:
10024-97-2.mol

NITROUS OXIDE Properties

Melting point:
−91 °C(lit.)
Boiling point:
−88 °C(lit.)
Density 
1.23 g/cm3 (-89 ºC)
vapor density 
1.53 (15 °C, vs air)
vapor pressure 
51.7 mm Hg ( 21 °C)
refractive index 
1.380
FEMA 
2779 | NITROUS OXIDE
solubility 
At 20 °C and at a pressure of 101 kPa, 1 volume dissolves in about 1.5 volumes of water.
form 
colorless gas
Water Solubility 
slightly soluble H2O; soluble alcohol, ether, conc H2SO4 [HAW93]
Merck 
13,6687
BRN 
8137358
Stability:
Oxidant, strongly supports combustion. May react violently with some materials. Thermal decomposition yields toxic products. Incompatible with aluminium, boron oxides, hydrazine, strong reducing agents.
CAS DataBase Reference
10024-97-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  O
Risk Statements  8
Safety Statements  38
RIDADR  UN 1070 2.2
WGK Germany  1
RTECS  QX1350000
4.5-31
HazardClass  2.2
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H270 May cause or intensify fire; oxidizer Oxidising gases Category 1 Danger P220, P244, P370+P376, P403
H280 Contains gas under pressure; may explode if heated Gases under pressure Compressed gas
Liquefied gas
Dissolved gas
Warning P410+P403
Precautionary statements:
P220 Keep/Store away from clothing/…/combustible materials.
P244 Keep reduction valves free from grease and oil.
P410+P403 Protect from sunlight. Store in a well-ventilated place.

NITROUS OXIDE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 295590 Nitrous oxide 99% 10024-97-2 227g $328 2018-11-20 Buy

NITROUS OXIDE Chemical Properties,Uses,Production

Chemical Properties

Colourless gas with sweetish odour

Chemical Properties

Nitrous oxide is a colorless gas. Slightly sweet odor. Shipped as a liquefied compressed gas.

Chemical Properties

Nitrous oxide is a nonflammable, colorless and odorless, sweettasting gas. It is usually handled as a compressed gas, stored in metal cylinders.

Uses

Nitrous Oxide is a noncombustible gas used as a propellant in certain dairy and vegetable fat whipped toppings contained in pressurized containers.

Definition

ChEBI: A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with ts non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Uses

Nitrous oxide was discovered by Priestley. It is found in the atmosphere in trace concentrations. The gas is used as an anesthetic, especially in dentistry and minor surgery. It produces mild hysteria and laughter preceding the anesthetic effect, for which reason it also is called “laughing gas.” It is used as an aerosol propellant, an aerating agent for whipped cream, and an oxidizing agent at high temperatures. Nitrous oxide also is used in the preparation of nitrites and as a flame gas in flame atomic absorption spectrometry of metals.

Production Methods

Nitrous oxide is prepared by heating ammonium nitrate to about 170°C. This reaction also forms water.

General Description

NITROUS OXIDE is a colorless, sweet-tasting gas. NITROUS OXIDE is also known as "laughing gas". Continued breathing of the vapors may impair the decision making process. NITROUS OXIDE is noncombustible but NITROUS OXIDE will accelerate the burning of combustible material in a fire. NITROUS OXIDE is soluble in water. Its vapors are heavier than air. Exposure of the container to prolonged heat or fire can cause NITROUS OXIDE to rupture violently and rocket. NITROUS OXIDE is used as an anesthetic, in pressure packaging, and to manufacture other chemicals.

Reactivity Profile

NITROUS OXIDE is an oxidizing agent. Nonflammable but supports combustion. Can explode at high temperature (after vaporization). Vapors can undergo a violent reaction with aluminum, boron, hydrazine, lithium hydride, phenyllithium, phosphine, sodium, tungsten carbide [Bretherick, 5th ed., 1995, p. 1686]. Contact of the cold liquefied gas with water may result in vigorous or violent boiling. If the water is hot, a liquid "superheat" explosion may occur. Pressures may build to dangerous levels if liquefied gas contacts water in a closed container [Handling Chemicals Safely 1980].

Hazard

Supports combustion, can form explosive mixture with air. Narcotic in high concentration. Central nervous system impairment, hematologic effects, and embryo/fetal damage. Questionable carcinogen.

Health Hazard

Inhalation causes intense analgesia; concentrations of over 40-60% cause loss of consciousness preceded by hysteria. Contact of liquid with eyes or skin causes frostbite burn.

Fire Hazard

Behavior in Fire: Will support combustion, and may increase intensity of fire. Containers may explode when heated.

Pharmaceutical Applications

Nitrous oxide and other compressed gases such as carbon dioxide and nitrogen are used as propellants for topical pharmaceutical aerosols. They are also used in other aerosol products that work satisfactorily with the coarse aerosol spray that is produced with compressed gases, e.g. furniture polish and window cleaner.
The advantages of compressed gases as aerosol propellants are that they are less expensive, of low toxicity, and practically odorless and tasteless. In contrast to liquefied gases, their pressures change relatively little with temperature. However, there is no reservoir of propellant in the aerosol, and as a result the pressure decreases as the product is used, changing the spray characteristics.
Misuse of a product by the consumer, such as using a product inverted, results in the discharge of the vapor phase instead of the liquid phase. Since most of the propellant is contained in the vapor phase, some of the propellant will be lost and the spray characteristics will be altered. Additionally, the sprays produced using compressed gases are very wet. However, recent developments in valve technology have reduced the risk of misuse by making available valves which will spray only the product (not propellant) regardless of the position of the container. Additionally, barrier systems will also prevent loss of propellant, and have found increased use with this propellant.
Therapeutically, nitrous oxide is best known as an anesthetic administered by inhalation. When used as an anesthetic it has strong analgesic properties but produces little muscle relaxation. Nitrous oxide is always administered in conjunction with oxygen since on its own it is hypoxic.

Safety Profile

Moderately toxic by inhalation. Human systemic effects by inhalation: general anesthetic, decreased pulse rate without blood pressure fall, and body temperature decrease. An experimental teratogen. Experimental reproductive effects. Mutation data reported. An asphyxiant. Does not burn but is flammable by chemical reaction and supports combustion. Moderate explosion hazard; it can form an explosive mixture with air. Violent reaction with Al, B, hydrazine, LiH, LiC6H5, PH3, Na, tungsten carbide. Also self-explodes at high temperatures.

Safety

Nitrous oxide is most commonly used therapeutically as an anesthetic and analgesic. Reports of adverse reactions to nitrous oxide therefore generally concern its therapeutic use, where relatively large quantities of the gas may be inhaled, rather than its use as an excipient.
The main complications associated with nitrous oxide inhalation occur as a result of hypoxia. Prolonged administration may also be harmful. Nitrous oxide is rapidly absorbed on inhalation.

Potential Exposure

Used as an anesthetic in dentistry and surgery; used as a gas in food aerosols, such as whipped cream; used in manufacture of nitrites; used in rocket fuels; in firefighting; diesel emissions. Large amounts of nitrous oxide will decrease the amount of available oxygen. Nitrous Oxide 2231 Oxygen should be routinely tested to ensure that it is at least 19% by volume.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

storage

Nitrous oxide is essentially nonreactive and stable except at high temperatures; at a temperature greater than 500°C nitrous oxide decomposes to nitrogen and oxygen. Explosive mixtures may be formed with other gases such as ammonia, hydrogen, and other fuels. Nitrous oxide should be stored in a tightly sealed metal cylinder in a cool, dry place.

Shipping

UN1070 Nitrous oxide, compressed, Hazard Class: 2.2; Labels: 2.2-Nonflammable compressed gas; 5.1-Oxidizer; UN2201 Nitrous oxide, refrigerated liquid, Hazard Class: 2.2; Labels: 2.2-Nonflammable compressed gas; 5.1-Oxidizer. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.

Purification Methods

Wash the gas with concentrated alkaline pyrogallol solution, to remove O2, CO2, and NO2, then dry it by passing it through columns of P2O5 or Drierite, and collecting in a dry trap cooled in liquid N2. It is further purified by freeze-pump-thaw and distillation cycles under vacuum [Ryan & Freeman J Phys Chem 81 1455 1977, Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 484-485 1963].

Incompatibilities

Nitrous oxide is a weak oxidizer. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Violent reactions with organic peroxides, hydrazine, hydrogen, hydrogen sulfide; lithium, boron, lithium hydride, sodium, aluminum, phosphine. This chemical is a strong oxidizer @ .300C and self-explodes at high temperature. May form explosive mixtures with ammonia, carbon monoxide; hydrogen sulfide; oil, grease and fuels.

Incompatibilities

Nitrous oxide is generally compatible with most materials encountered in pharmaceutical formulations, although it may react as a mild oxidizing agent.

Waste Disposal

Disperse in atmosphere or spray on dry soda ash/lime with great care; then flush to sewer.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in nonparenteral medicines licensed in the UK and USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

NITROUS OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products


NITROUS OXIDE Suppliers

Global( 38)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai wechem chemical co., ltd 021-5198 7501
021-6192 7501 info@wechem.cn China 286 58
9ding chemical ( Shanghai) Limited 4009209199
86-021-52271987 sales@9dingchem.com China 22651 55
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 shenlinxing@macklin.cn China 15820 55
Sigma-Aldrich 021-61415566 800-819-3336(Tel) 400-620-3333(Mobile)
021-61415567 orderCN@sial.com China 28593 80
AoboRui (Tianjin) Co., Ltd. 86 022 65675308 18310521067
86 022 65675308 23034325@qq.com China 161 55
Zibo Zeno Pharmaceutical Technology Co., Ltd. 0533-8800999 13515338377
0533-7544744 zenuoyiyao@163.com China 57 58

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