4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 478832-21-2
- Chemical Name:
- 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-4-Hydroxyazepane;N-Boc-4-hydroxyazepane;1-Boc-Hexahydro-1H-azepin...;N-BOC-HEXAHYDRO-1H-AZEPIN-4-OL;1-Boc-Hexahydro-1H-azepin-4-ol;4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-hydroxy-1-azepanecarboxylic acid tert-butyl ester;tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate;4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;1H-AZEPINE-1-CARBOXYLIC ACID, HEXAHYDRO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER
- CBNumber:
- CB7678424
- Molecular Formula:
- C11H21NO3
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD07368610
- MOL File:
- 478832-21-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Hydroxyazepane-1-carboxylicacidtert-butylester | H829958 | 250mg | $55 |
| 4-Hydroxyazepane-1-carboxylicacidtert-butylester | H829958 | 500mg | $65 |
| 1-Boc-hexahydro-1H-azepin-4-ol | 4H56-1-LP | 250mg | $59 |
| 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% | CHM1050601 | 1G | $160.65 |
| 1-Boc-hexahydro-1H-azepin-4-ol | 4H56-1-LP | 5G | $297 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN2811 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H829958 | 4-Hydroxyazepane-1-carboxylicacidtert-butylester | 478832-21-2 | 250mg | $55 | 2021-12-16 | Buy |
| TRC | H829958 | 4-Hydroxyazepane-1-carboxylicacidtert-butylester | 478832-21-2 | 500mg | $65 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-LP | 1-Boc-hexahydro-1H-azepin-4-ol | 478832-21-2 | 250mg | $59 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM1050601 | 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% | 478832-21-2 | 1G | $160.65 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-LP | 1-Boc-hexahydro-1H-azepin-4-ol | 478832-21-2 | 5G | $297 | 2021-12-16 | Buy |
4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Synthesis
39888-51-2
24424-99-5
478832-21-2
(c) Synthesis of tert-butyl 4-hydroxyazepane-1-carboxylate: Ammonium formate (900 mg) and 10% palladium/carbon catalyst (200 mg) were added to an ethanol solution (10 mL) of 1-benzyl-4-azepane (450 mg, 2.19 mmol), and the reaction mixture was heated and refluxed for 1 hour. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The resulting residue was dissolved in dichloromethane (10 mL) and di-tert-butyl dicarbonate (0.504 mL, 2.19 mmol) was added at room temperature with continuous stirring for 19 hours. At the end of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture, followed by water and extraction with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=2/1) to afford the target compound tert-butyl 4-hydroxyazepane-1-carboxylate (333 mg, 70% yield).
References
[1] Patent: EP1500643, 2005, A1. Location in patent: Page 48
4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49946 | 58 |
View Lastest Price from 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-03 | 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
478832-21-2
|
US $7.00 / KG | 1KG | 99% | JD 725 | Career Henan Chemical Co |
-
- 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
478832-21-2
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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