5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
![5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Structure](CAS/GIF/101083-92-5.gif)
- CAS No.
- 101083-92-5
- Chemical Name:
- 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
- Synonyms
- 5-NITRO-7-AZAINDOLE;5-Nitro-7-azaindole,97%;5-Nitro-7-aza-1H-indole;5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 5-nitro-;5-nitro-1H-pyrrolo[2,3-b]pyridine 97%min;TIANFU-CHEM 101083-92-5 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
- CBNumber:
- CB7690297
- Molecular Formula:
- C7H5N3O2
- Molecular Weight:
- 163.13
- MDL Number:
- MFCD06659682
- MOL File:
- 101083-92-5.mol
| Product description | Number | Pack Size | Price |
| 5-Nitro-1H-pyrrolo[2,3-b]pyridine | N520120 | 100mg | $165 |
| 5-Nitro-1H-pyrrolo[2,3-b]pyridine 96.39% | CS-B0505 | 10g | $170 |
| 5-Nitro-7-azaindole 97% | 4H55-1-70 | 5G | $288 |
| 5-Nitro-1H-pyrrolo[2,3-b]pyridine 96.39% | CS-B0505 | 1g | $27 |
| 5-Nitro-1H-pyrrolo[2,3-b]pyridine | OR308037 | 1g | $73 |
| More product size | |||
| Melting point | 280℃ |
|---|---|
| Boiling point | 392.8±35.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 0.65±0.20(Predicted) |
| color | yellow |
| InChI | InChI=1S/C7H5N3O2/c11-10(12)6-3-5-1-2-8-7(5)9-4-6/h1-4H,(H,8,9) |
| InChIKey | INMIPMLIYKQQID-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC([N+]([O-])=O)=CN=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | N520120 | 5-Nitro-1H-pyrrolo[2,3-b]pyridine | 101083-92-5 | 100mg | $165 | 2021-12-16 | Buy |
| ChemScene | CS-B0505 | 5-Nitro-1H-pyrrolo[2,3-b]pyridine 96.39% | 101083-92-5 | 10g | $170 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H55-1-70 | 5-Nitro-7-azaindole 97% | 101083-92-5 | 5G | $288 | 2021-12-16 | Buy |
| ChemScene | CS-B0505 | 5-Nitro-1H-pyrrolo[2,3-b]pyridine 96.39% | 101083-92-5 | 1g | $27 | 2021-12-16 | Buy |
| Apolloscientific | OR308037 | 5-Nitro-1H-pyrrolo[2,3-b]pyridine | 101083-92-5 | 1g | $73 | 2021-12-16 | Buy |
5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Uses,Production
Uses
5-Nitro-1H-pyrrolo[2,3-b]pyridine is a reagent used in the synthesis of Cdc7 kinase inhibitors used as a novel cancer therapy. Also an intermediate in the synthesis of 4-anilinoquinazolines as potential anticancer agents.
Synthesis
![1H-Pyrrolo[2,3-b]pyridine, 5-nitro-1-(phenylsulfonyl)-](/CAS/GIF/937012-11-8.gif)
937012-11-8
![5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE](/CAS/GIF/101083-92-5.gif)
101083-92-5
To a stirred suspension of 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (10.2 g, 33 mmol) in methanol (250 mL) was added powdered sodium hydroxide (2 g, 50 mmol) in batches. After stirring the reaction mixture for 30 min at room temperature, powdered sodium hydroxide (2 g, 50 mmol) and dichloromethane (50 mL) were added again and stirring was continued for 30 min. Upon completion of the reaction, the mixture was concentrated, followed by the addition of a mixed solution of 2N HCl (50 mL) and water (200 mL), and the resulting mixture was filtered. The yellow filter cake was washed with water and dried to afford 5-nitro-1H-pyrrolo[2,3-b]pyridine (4.6 g, 28.2 mmol, 85% yield). The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 6.78 (dd, J = 3.50, 1.83 Hz, 1H), 7.79 (dd, J = 3.35, 2.59 Hz, 1H), 8.90-8.92 (m, 1H), 9.13 (d, J = 2.59 Hz, 1H), 12.05- 12.92 (m, 1H).
References
[1] Patent: US2007/112020, 2007, A1. Location in patent: Page/Page column 36
5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13505 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21615 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE pictures](https://img.chemicalbook.com/ProductImageEN/2019-8/Small/749ae852-fb61-4b5b-ba66-8a625c577daa.png) |
2019-08-06 | 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
101083-92-5
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
101083-92-5
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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