L-METHIONINE SULFOXIMINE
- CAS No.
- 15985-39-4
- Chemical Name:
- L-METHIONINE SULFOXIMINE
- Synonyms
- L-METHIONINE-DL-SULFOXIMINE;L-Methionine [R,S]-Sulfoximine;MSX;L-Methionine Sulfoxime;L-Methionin-sulfoximine;L-METHIONINE SULFOXIMINE;L-Methionine sulfoxiimine;METHIONINE SULFOXIMINE (L);Methionine-rs-sulfoximine, L-;Methionine-DL-sulfoximine, DL-
- CBNumber:
- CB7690727
- Molecular Formula:
- C5H12N2O3S
- Molecular Weight:
- 180.23
- MDL Number:
- MFCD00002621
- MOL File:
- 15985-39-4.mol
- MSDS File:
- SDS
| Melting point | >210 °C (dec.)(lit.) |
|---|---|
| Boiling point | 352.2±52.0 °C(Predicted) |
| Density | 1.215 (estimate) |
| refractive index | 1.6430 (estimate) |
| storage temp. | 20-25°C |
| solubility | Aqueous Base (Slightly), Formic Acid (Slightly), Water (Sparingly, Sonicated) |
| form | Crystalline Powder |
| color | White or almost white |
| optical activity | [α]20/D +10.8 to +14.0°, c = 1 in H2O |
| BRN | 6175446 |
| Stability | Temperature Sensitive |
| CAS DataBase Reference | 15985-39-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | M9P6YZ6JX9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
L-METHIONINE SULFOXIMINE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27608 | L-Methionine-(S,R)-Sulfoximine | 15985-39-4 | 50mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 27608 | L-Methionine-(S,R)-Sulfoximine | 15985-39-4 | 100mg | $57 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5379 | L-Methionine sulfoximine | 15985-39-4 | 250mg | $133 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5379 | L-Methionine sulfoximine | 15985-39-4 | 500mg | $211 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5379 | L-Methionine sulfoximine | 15985-39-4 | 1g | $312 | 2024-03-01 | Buy |
L-METHIONINE SULFOXIMINE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Powder
Uses
L-Methionine sulfoximine has been used as a potent inhibitor of glutamine synthetase (GS) activity.
Uses
glutamine synthetase inhibitor, ornithine decarboxylase enhancer, convulsant
Uses
Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM). Methionine sulfoximine is also a toxic
Definition
ChEBI: L-methionine sulfoximine is a methionine sulfoximine in which the amino group has S-stereochemistry. It has a role as a geroprotector and an EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor. It is a methionine sulfoximine, a L-methionine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a L-methionine sulfoximine zwitterion.
Biochem/physiol Actions
As a potent inhibitor of glutamine synthetase activity (GS), this reagent has widely been used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthetase results in cell death for cells lacking overexpression. The MSX-glutamine synthetase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia.
L-METHIONINE SULFOXIMINE Preparation Products And Raw materials
Raw materials
Preparation Products
L-METHIONINE SULFOXIMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29576 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9571 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
View Lastest Price from L-METHIONINE SULFOXIMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | L-METHIONINE SULFOXIMINE
15985-39-4
|
US $2.00 / KG | 1g | 98%min | ask | Career Henan Chemical Co |
-
- L-METHIONINE SULFOXIMINE
15985-39-4
- US $2.00 / KG
- 98%min
- Career Henan Chemical Co