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Terfenadine

Terfenadine
Terfenadine structure
CAS No.
50679-08-8
Chemical Name:
Terfenadine
Synonyms
Cyater;Terdin;terfen;Terfex;Aldaban;mdl9918;rmi9918;seldane;Teldane;MDL-9918
CBNumber:
CB7695393
Molecular Formula:
C32H41NO2
Formula Weight:
471.67
MOL File:
50679-08-8.mol

Terfenadine Properties

Melting point:
145-152 °C
Boiling point:
572.76°C (rough estimate)
Density 
1.0488 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
2-8°C
solubility 
chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow
pka
pKa 9.21(H2O t = 25 I = 0.025) (Uncertain)
form 
neat
Water Solubility 
0.001 g/100 mL (30 ºC)
CAS DataBase Reference
50679-08-8(CAS DataBase Reference)
NIST Chemistry Reference
Seldane(50679-08-8)
SAFETY
  • Risk and Safety Statements
Hazard statements  H303-H413
Safety Statements  24/25
WGK Germany  2
RTECS  TM4969000
HS Code  29333999
Toxicity LD50 orally in mice: >2000 mg/kg (Carr, Meyer)

Terfenadine price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T9652 Terfenadine 50679-08-8 5g $85.5 2018-11-13 Buy
Sigma-Aldrich 1643805 Terfenadine United States Pharmacopeia (USP) Reference Standard 50679-08-8 200mg $348 2018-11-13 Buy
Alfa Aesar J61936 Terfenadine 50679-08-8 100mg $278 2018-11-20 Buy
Cayman Chemical 20305 Terfenadine ≥98% 50679-08-8 500mg $25 2018-11-19 Buy
Cayman Chemical 20305 Terfenadine ≥98% 50679-08-8 1g $43 2018-11-19 Buy

Terfenadine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Nonsedating-type histamine H1-receptor antagonist. Antihistaminic

Uses

H1 antihistamine

brand name

Antifen;Fenadin.

World Health Organization (WHO)

The first clinically interesting histamine H-receptor1 antagonists were introduced in the late 1940s and early 1950s. Several H-antihistaminics have a similar cardiac effect to that seen with astemizole1 and terfenadine. Serious cardiovascular adverse reactions have been reported when used concomitantly with imidazole antifungals and macrolide antibiotics. See also under astemizole.

Biological Activity

Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .

Terfenadine Preparation Products And Raw materials

Raw materials

Preparation Products


Terfenadine Suppliers

Global( 100)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shandong chuangyingchemical Co., Ltd.
13156170209
sale@chuangyingchem.com CHINA 4405 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 279 60
Jia Xing Isenchem Co.,Ltd 0573-85280080,18627885956
0573-85285100 isenchem@163.com,QQ:2446116053 China 9715 66
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70

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