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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester structure

CAS No.: 206989-61-9

Chemical Name:: 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Synonyms: tert-Butyl 4-acetylpiperidine-1-carboxylate;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;N-Boc-4-acetylpiperidine;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE

CBNumber:: CB7704363

Molecular Formula:: C12H21NO3

Molecular Weight:: 227.3

MDL Number:: MFCD08437655

MOL File:: 206989-61-9.mol

MSDS File:: SDS

Last updated:2024-03-08 16:13:53

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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Properties

Boiling point	312.4±35.0 °C(Predicted)
Density	1.052±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-2.23±0.40(Predicted)
InChI	InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey	HNVBBNZWMSTMAZ-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
HazardClass	IRRITANT
HS Code	2933399990

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00409	tert-Butyl 4-acetylpiperidine-1-carboxylate	206989-61-9	1g	$29.8	2024-03-01	Buy
TRC	T135528	tert-Butyl 4-acetylpiperidine-1-carboxylate	206989-61-9	100mg	$60	2021-12-16	Buy
Apolloscientific	OR321452	tert-Butyl 4-acetylpiperidine-1-carboxylate 98%	206989-61-9	1g	$15	2021-12-16	Buy
Oakwood	048392	N-Boc-4-Acetylpiperidine 98%	206989-61-9	250mg	$15	2021-12-16	Buy
SynQuest Laboratories	4H56-1-LS	N-Boc-4-acetyl piperidine	206989-61-9	1g	$24	2021-12-16	Buy

Product number	Packaging	Price	Buy
SYX00409	1g	$29.8	Buy
T135528	100mg	$60	Buy
OR321452	1g	$15	Buy
048392	250mg	$15	Buy
4H56-1-LS	1g	$24	Buy

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester synthesis

Synthesis of 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester from 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Methylmagnesium Bromide

Preparation Products

2-bromo-1-(1-Boc-piperidin-4-yl)ethanone TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

Global( 223)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3716	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2169	58

Supplier	Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Anhui Dexinjia Biopharm Co., Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-26	N-Boc-4-acetylpiperidine 206989-61-9	US $0.00 / KG	1KG	98%	2M per month	Anhui Dexinjia Biopharm Co., Ltd
	2019-07-06	N-Boc-4-piperidineacetate 206989-61-9	US $1.00 / KG	1KG	98%	500kg	Career Henan Chemical Co

N-Boc-4-acetylpiperidine
206989-61-9
US $0.00 / KG
98%
Anhui Dexinjia Biopharm Co., Ltd

N-Boc-4-piperidineacetate
206989-61-9
US $1.00 / KG
98%
Career Henan Chemical Co

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Spectrum

4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)¹HNMR 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)FT-IR

206989-61-9(4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester)Related Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- (R)-Zanubrutinib 4-PHENOXYBENZOIC ACID Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-

Zanubrutinib 1-Boc-hexahydro-1H-azepin-4-amine 1-Boc-4-cyanopiperidine 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate

tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1of4

4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-4-Acetylpiperidine N-Boc-4-acetylpiperidine 1-tert-Butoxycarbonyl-4-acetylpiperidine 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester 1-BOC-4-ACETYL-PIPERIDINE N-Boc-4-Acetypiperidine 1-BOC-ESTER4-ACETYL-PIPERIDINE 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester tert-butyl 4-ethanoylpiperidine-1-carboxylate 4-acetyl-1-(t-butoxycarbonyl)piperidine 1-Boc-4-acetyL Zanubrutinib Related Compound 4 Zanubrutinib Impurity 6 -N-Boc-4-Acetylpiperidine tert-Butyl 4-acetylpiperidine-1-carboxylate 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Zanubrutinib benzoyl amide impurity Zanubrutinib impurity-22 206989-61-9 206979-61-9 C12H20NO4