Chinese Japanese Germany Korea

Diphenhydramine Hydrochloride

Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications
Diphenhydramine Hydrochloride
Diphenhydramine Hydrochloride structure
Chemical Name:
Diphenhydramine Hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

Diphenhydramine Hydrochloride Properties

Melting point:
168-172 °C
Boiling point:
163-167 °C(Press: 3 Torr)
1.0489 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
storage temp. 
Very soluble in water, freely soluble in alcohol.
Crystalline Powder or Adhering Crystals
pH(100g/L, 25℃) 4.0~5.5
Water Solubility 
1000 g/L
Light Sensitive
Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
CAS DataBase Reference
147-24-0(CAS DataBase Reference)
310.545; 336.10; 338.10; 341.12; 341.14
EWG's Food Scores
NCI Drug Dictionary
diphenhydramine hydrochloride
NIST Chemistry Reference
diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System
Diphenhydramine hydrochloride (147-24-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H302-H225-H301+H311+H331-H370
Precautionary statements  P301+P312a-P330-P501a-P210-P260-P280-P301+P310-P311-P264-P270-P501-P301+P312+P330
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7-24/25
RIDADR  2811
WGK Germany  3
RTECS  KR7000000
HS Code  29221990
Toxicity LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)

Diphenhydramine Hydrochloride price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D-015 Diphenhydramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 147-24-0 1 mL $20.9 2021-03-22 Buy
Sigma-Aldrich D3630 Diphenhydramine hydrochloride ≥98% (HPLC) 147-24-0 5g $39.4 2021-03-22 Buy
Sigma-Aldrich D2600000 Diphenhydramine hydrochloride European Pharmacopoeia (EP) Reference Standard 147-24-0 $190 2021-03-22 Buy
Sigma-Aldrich BP896 Diphenhydramine hydrochloride British Pharmacopoeia (BP) Reference Standard 147-24-0 $190 2021-03-22 Buy
Sigma-Aldrich 1218005 Diphenhydramine hydrochloride United States Pharmacopeia (USP) Reference Standard 147-24-0 200mg $366 2021-03-22 Buy

Diphenhydramine Hydrochloride Chemical Properties,Uses,Production


Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride structural formula
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.

Clinical Pharmacology

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.

Indications and Usage

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  2. Motion Sickness: For active treatment of motion sickness.
  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

Drug overdose

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.


  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.

Chemical Properties

White or almost white, crystalline powder.


Benadryl,Parke Davis,US,1946


Diphenhydramine hydrochloride is used as an antihistamine and for its antieholinergie (drying) and sedative effects; for allergic conjunctivitis due to foods; for mild, uncomplicated allergic skin manifestations of urticaria and angioedema; for amelioration of allergic reactions to blood or plasma; for dermatographism; in therapy for anaphylaetie reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; for active and prophylactie treatment of motion sickness; for parkinsonism; an antiemetic; has local anesthetic properties; in preparations for the relief of cough; in the prevention and treatment of radiation sickness, nausea and vomiting; for treatment of allergie cheilitis and stomatitis.


Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.


antihistamine, sedative, treatment of allergic


A histamine H1-receptor antagonist.


H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic


ChEBI: The hydrochloride salt of diphenhydramine.

Manufacturing Process

As described in US Patent 2,421,714: (a) benzhydryl
omide is first prepared as follows: 840 parts by weight of diphenylmethane is heated to 130°C with stirring. In the presence of a 200 watt electric light 6 inches from the flask, 880 parts of
omine is added slowly. Liberation of H
occurs and addition requires 1 hour and 45 minutes. The temperature is maintained at 130°C for an additional 30 minutes. A fine stream of air is blown in to remove H
2 while the reaction mixture cools. Benzene (180 parts) is added and the solution used immediately in (b) below.
If pure benzhydryl
omide is desired the above reaction mixture is dissolved in ether, washed with water, sodium carbonate solution and finally with water. The ether is removed, benzene added and distilled off and the benzhydryl
omide distilled in vacuo. Yield 85%.
(b) 490 parts β-dimethylaminoethanol and 530 parts of anhydrous sodium carbonate are heated to 110°C with stirring. The addition of the benzenebenzhydryl
omide mixture is then begun. The temperature is raised to 120°- 125°C. As reaction takes place carbon dioxide is evolved, the addition requires1? hours. The mixture is kept at 125°C for 5 hours additional time. After cooling, 3,000 parts of water is added and the mixture stirred until the inorganic salts are dissolved. The mixture is transferred to a large separatory funnel and 1,500 parts of ether added. The ether solution is washed several times with water and then the ether layer extracted with 1 to 4 hydrochloric acid. The acid solution is treated with 30 parts of Darco and 30 parts Filter-Cel and filtered.
The free base is liberated from the acid solution with 20% sodium hydroxide solution and taken up in ether. The ether layer is washed with water, saturated with NaCl and then shaken with solid potassium hydroxide. The ether is removed by distillation, 200 parts of benzene added and distilled off. The residue is distilled in vacuo and the fraction 150°-165°C/2 mm is collected and amounts to 433 parts. The hydrochloride salt is prepared by dissolving the free base in anhydrous ether and slowly adding an alcoholic solution of hydrogen chloride. The solid is recrystallized from absolute alcohol-ether mixture or isopropanol-ether mixture and has a MP of 161-162°C.

brand name

Benadryl (Parke-Davis).

Therapeutic Function


General Description

Diphenhydramine hydrochloride, 2-(diphenylmethoxy)- N,N-dimethylethanamine hydrochloride (Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, white crystalline powder soluble in water (1:1), alcohol (1:2) and chloroform (1:2). The salt has a pKa value of 9, and a 1% aqueous solution has a pH of about 5.
In addition to antihistaminic action, diphenhydramine exhibits antidyskinetic, antiemetic, antitussive and antimuscarinic, and sedative properties.As an antihistaminic agent, diphenhydramine is recommended in various allergic conditions and, to a lesser as an antitussive and Parkinsonism drug. It is also used in OTC sleep-aid products. It is administered either orally or parenterally in the treatment of urticaria, seasonal rhinitis (hay fever), and some dermatoses.

General Description

White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.

Air & Water Reactions

Water soluble. Aqueous solutions are acidic.

Reactivity Profile

N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

Fire Hazard

Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible.

Biological Activity

H 1 receptor antagonist. Antihistamine.

Contact allergens

This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also ESTERS and ETHERS.

Veterinary Drugs and Treatments

In veterinary medicine, diphenhydramine is used principally for its antihistaminic effects, but also for other pharmacologic actions. Its sedative effects can be of benefit in treating the agitation (pruritus, etc.) associated with allergic responses. It has also been used for treatment and prevention of motion sickness and as an antiemetic in small animals. It has been suggested for use as adjunctive treatment of aseptic laminitis in cattle and it may be useful as an adjunctive treatment for feline pancreatitis. For other suggested uses, refer to the Dosage section below.

Diphenhydramine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Diphenhydramine Hydrochloride Suppliers

Global( 439)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shijiazhuang Gantuo Biotechnology Co., Ltd
+8613373514458 +86-86-13373514458 China 623 58
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Xingtai Haoxun Import and Export Trade Co., Ltd.
+8617733977883 WhatsApp:+8617733976525
86-0319-5021664 CHINA 270 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418697 CHINA 37441 58
13588875226 86-571-88216897、88216896
86-571-88216895 CHINA 6469 58
Hebei Qige Biological Technology Co. Ltd
8618733132031 CHINA 1322 58
Baoji Guokang Healthchem co.,ltd
09178656283 CHINA 9476 58
Hong Kong Excellence Biotechnology Co., Ltd.
wickrme:chemical888 China 764 58
Wuhan Golt Biotech Co., Ltd.
+8615389281203 China 980 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20918 58

View Lastest Price from Diphenhydramine Hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Diphenhydramine Hydrochloride
US $40.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-11-26 diphenhydramine
US $30.00 / KG 10g 99%min 1tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-11-26 Diphenhydramine hydrochloride
US $30.00 / KG 10g 99%min 1TONS Xingtai Haoxun Import and Export Trade Co., Ltd.

Diphenhydramine Hydrochloride Spectrum

147-24-0(Diphenhydramine Hydrochloride)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved