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Diphenhydramine Hydrochloride

Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications
Diphenhydramine Hydrochloride
Diphenhydramine Hydrochloride structure
Chemical Name:
Diphenhydramine Hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

Diphenhydramine Hydrochloride Properties

Melting point:
168-172 °C
1.0489 (rough estimate)
refractive index 
1.5800 (estimate)
Flash point:
storage temp. 
Desiccate at RT
Very soluble in water, freely soluble in alcohol.
Crystalline Powder or Adhering Crystals
pH(100g/L, 25℃) 4.0~5.5
Water Solubility 
1000 g/L
Light Sensitive
Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
CAS DataBase Reference
147-24-0(CAS DataBase Reference)
NIST Chemistry Reference
diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride(147-24-0)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7-24/25
RIDADR  2811
WGK Germany  3
RTECS  KR7000000
HS Code  29221990
Toxicity LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…

Diphenhydramine Hydrochloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D3630 Diphenhydramine hydrochloride ≥98% (HPLC) 147-24-0 5g $36.6 2018-11-13 Buy
Sigma-Aldrich 1218005 Diphenhydramine hydrochloride United States Pharmacopeia (USP) Reference Standard 147-24-0 200mg $352.8 2018-11-13 Buy
TCI Chemical D0423 Diphenhydramine Hydrochloride >98.0%(HPLC)(T) 147-24-0 25g $30 2018-11-22 Buy
TCI Chemical D0423 Diphenhydramine Hydrochloride >98.0%(HPLC)(T) 147-24-0 500g $224 2018-11-22 Buy
Alfa Aesar A10136 Diphenhydramine hydrochloride 99% 147-24-0 250g $86.1 2018-11-20 Buy

Diphenhydramine Hydrochloride Chemical Properties,Uses,Production


Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride structural formula
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.

Clinical Pharmacology

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.

Indications and Usage

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  2. Motion Sickness: For active treatment of motion sickness.
  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

Drug overdose

Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.


  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.

Chemical Properties

White or almost white, crystalline powder.


Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.


antihistamine, sedative, treatment of allergic


A histamine H1-receptor antagonist.


H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic


ChEBI: The hydrochloride salt of diphenhydramine.

brand name

Benadryl (Parke-Davis).

General Description

Diphenhydramine hydrochloride, 2-(diphenylmethoxy)- N,N-dimethylethanamine hydrochloride (Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, white crystalline powder soluble in water (1:1), alcohol (1:2) and chloroform (1:2). The salt has a pKa value of 9, and a 1% aqueous solution has a pH of about 5.
In addition to antihistaminic action, diphenhydramine exhibits antidyskinetic, antiemetic, antitussive and antimuscarinic, and sedative properties.As an antihistaminic agent, diphenhydramine is recommended in various allergic conditions and, to a lesser as an antitussive and Parkinsonism drug. It is also used in OTC sleep-aid products. It is administered either orally or parenterally in the treatment of urticaria, seasonal rhinitis (hay fever), and some dermatoses.

General Description

White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.

Air & Water Reactions

Water soluble. Aqueous solutions are acidic.

Reactivity Profile

N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

Fire Hazard

Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible.

Biological Activity

H 1 receptor antagonist. Antihistamine.

Contact allergens

This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also ESTERS and ETHERS.

Diphenhydramine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Diphenhydramine Hydrochloride Suppliers

Global( 276)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 552 55
Hebei Ruishun Trade Co.,LTD
17052563120 CHINA 299 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1662 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 215 58
Jinan Jianfeng Chemical Co., Ltd
15562555968 CHINA 617 58

View Lastest Price from Diphenhydramine Hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Diphenhydramine Hydrochloride
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-05 Diphenhydramine Hydrochloride
US $500.00 / KG 1KG 99% 100000KG Hubei XinRunde Chemical Co., Ltd.
2018-05-24 Diphenhydramine Hydrochloride
US $1.00 / G 1G 99.5% 10000000 Meihua Biological Technology Co.,Ltd

Diphenhydramine Hydrochloride Spectrum

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