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ORIENTIN

ORIENTIN structure

CAS No.: 28608-75-5

Chemical Name:: ORIENTIN

Synonyms: LUTEOLIN-8-C-GLUCOSIDE;Polygonin;Luteolin 8-C-β-D-glucopyranoside;lutexin;ORIENTIN;ORIENTINE;Aids026706;Aids-026706;ORIENTIN(P);ORIENTIN,NA

CBNumber:: CB7710333

Molecular Formula:: C21H20O11

Molecular Weight:: 448.38

MDL Number:: MFCD00017432

MOL File:: 28608-75-5.mol

Last updated:2025-10-29 15:43:00

Product description	Number	Pack Size	Price
Orientin ≥97% (HPLC)	O9765	1mg	$127.24
Orientin primary pharmaceutical reference standard	03810585	10mg	$692
Orientin	O0503	25MG	$86
Orientin	O0503	100MG	$215
Orientin ≥95%	25143	25mg	$61
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ORIENTIN Properties

Melting point	260-285°C
Boiling point	816.1±65.0 °C(Predicted)
Density	1.759±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	1 M NaOH: soluble1mg/mL, clear, yellow-orange
pka	6.24±0.40(Predicted)
form	powder
color	yellow
Stability	Hygroscopic
InChIKey	PLAPMLGJVGLZOV-FYNBPVOANA-N
SMILES	C12OC(=CC(=O)C=1C(=CC(O)=C2[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)O)C1C=CC(O)=C(O)C=1 \|&1:12,13,15,16,18,r\|
LogP	1.580 (est)
FDA UNII	IAX93XCW6C
UNSPSC Code	85151701
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

Safety Statements

24/25

WGK Germany

RTECS

DJ3009300

HS Code

29389090

NFPA 704

	0
2		0

ORIENTIN price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	O9765	Orientin ≥97% (HPLC)	28608-75-5	1mg	$127.24	2025-07-31	Buy
Sigma-Aldrich	03810585	Orientin primary pharmaceutical reference standard	28608-75-5	10mg	$692	2025-07-31	Buy
TCI Chemical	O0503	Orientin	28608-75-5	25MG	$86	2025-07-31	Buy
TCI Chemical	O0503	Orientin	28608-75-5	100MG	$215	2025-07-31	Buy
Cayman Chemical	25143	Orientin ≥95%	28608-75-5	25mg	$61	2024-03-01	Buy

Product number	Packaging	Price	Buy
O9765	1mg	$127.24	Buy
03810585	10mg	$692	Buy
O0503	25MG	$86	Buy
O0503	100MG	$215	Buy
25143	25mg	$61	Buy

ORIENTIN Chemical Properties,Uses,Production

Description

Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC₅₀ value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC₅₀ value of 11.7 μg/ml and a cytotoxic concentration (CC₅₀) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.

Chemical Properties

Yellow powder

Uses

Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.

Definition

ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.

in vivo

Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model^[1].
Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model^[2].

Animal Model:	PCA mouse model^[1]
Dosage:	0.1–10 mg/kg
Administration:	Oral gavage (p.o.); Euthanized mouse after 1 h
Result:	Significantly suppressed PCA reactions in PCA mouse model.

Animal Model:	SNL rat model^[2]
Dosage:	10, 20, 40 mg/kg
Administration:	Intraperitoneal injection (i.p.); Once daily for 12 days
Result:	Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model. Decreased the levels of IL-6, IL-1β and TNF-α. Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NAN WU. Antioxidant activities of extracts and main components of Pigeonpea [Cajanus cajan (L.) Millsp.] leaves.[J]. Molecules, 2009, 14 3: 1032-1043. DOI: 10.3390/molecules14031032
[3] YAO-LAN LI . Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge[J]. Journal of ethnopharmacology, 2002, 79 3: Pages 365-368. DOI: 10.1016/s0378-8741(01)00410-x
[4] WONHWA LEE Jong S B Sae Kwang Ku. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo[J]. Vascular pharmacology, 2014, 62 1: Pages 3-14. DOI: 10.1016/j.vph.2014.04.006

ORIENTIN Preparation Products And Raw materials

Raw materials

Preparation Products

ORIENTIN Suppliers

Global( 299)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Wuhan ChemNorm Biotech Co.,Ltd.	58

View Lastest Price from ORIENTIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-24	Orientin 28608-75-5	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2023-02-13	Orientin 28608-75-5	US $90.00 / kg	1kg	99%	80MT	Hebei baicao biology science and technology co., ltd
2021-07-13	Orientine 28608-75-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Orientin
28608-75-5
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Orientin
28608-75-5
US $90.00 / kg
99%
Hebei baicao biology science and technology co., ltd

Orientine
28608-75-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ORIENTIN Spectrum

ORIENTIN(28608-75-5)¹HNMR ORIENTIN(28608-75-5)IR1 ORIENTIN(28608-75-5)IR2

28608-75-5(ORIENTIN)Related Search:

4-N-HEXYLPHENOL 5-ETHYL-2-HYDROXY-BENZALDEHYDE 1-(2-Hydroxy-5-methylphenyl)ethanone 4-Phenylbutanol ORIENTIN

4'-Hydroxy-3'-methylacetophenone (S)-(-)-3-BENZYLOXY-1,2-PROPANEDIOL 1-(3-METHYLPHENYL)ETHANOL (S)-(+)-1-Phenyl-1,2-ethanediol (S)-(+)-4-PHENYL-2-BUTANOL

1,2,3-HEPTANETRIOL 2-Benzyloxyethanol 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE 4-Hexylresorcinol Vitexin

1-O-BENZYL-RAC-GLYCEROL 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE HOMOORIENTIN(ISOORIENTIN)(P)

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2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one ORIDONIN (RG) 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-.beta.-D-glucopyranosyl-5,7-dihydroxy- Aids026706 Aids-026706 8-Glucosylluteolin ORIENTIN ORIENTINE Orientin, froM PolygonuM orientale Orientin,Lutexin 2-(3,4-dihydroxyphenyl)-8-beta-d-glucopyranosyl-5,7-dihydroxy-4h-1-benzopyra 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-beta-d-glucopyranosyl-5,7-dihy luteolin8-glucoside lutexin orientin(flavone) ORIENTIN(P) ORIENTIN(SH) ORIENTIN WITH HPLC 8-β-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(β-D-glucopyranosyl)-4H-1-benzopyran-4-one 2-(3,4-Dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one Orientin, 98%, from Polygonum orientale L. Orientin, 98%, from Polygonum orientale 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy- Luteolin 8-C-beta-D-Glucopyranoside 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone ORIENTIN USP/EP/BP 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one OrientinQ: What is Orientin Q: What is the CAS Number of Orientin Q: What is the storage condition of Orientin Q: What are the applications of Orientin LUTEOLIN-8-C-GLUCOSIDE Luteolin 8-C-β-D-glucopyranoside Polygonin 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-b-D-glucopyranosyl-5,7-dihydroxy- ORIENTIN,NA Orientin, 10 mM in DMSO Orientin 100 μg/mL in Acetonitrile:Water 28608-75-5 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Aromatics, Glucuronides, Pharmaceuticals, Intermediates & Fine Chemicals