ChemicalBook >> CAS DataBase List >>2-Chloronicotinic acid

2-Chloronicotinic acid

Chemical Name:
2-Chloronicotinic acid
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2023-05-25

2-Chloronicotinic acid Properties

Melting point 176-178 °C (dec.)(lit.)
Boiling point 316.8±22.0 °C(Predicted)
Density 1.470±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO, Ethyl Acetate (Slightly)
pka 2.07±0.25(Predicted)
form Powder
color White to cream
BRN 119023
LogP 0.988
CAS DataBase Reference 2942-59-8(CAS DataBase Reference)
FDA UNII 93G386213F
EPA Substance Registry System 2-Chloronicotinic acid (2942-59-8)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333999
NFPA 704
2 0

2-Chloronicotinic acid price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 150339 2-Chloropyridine-3-carboxylic acid 99% 2942-59-8 10g $47.6 2023-01-07 Buy
Sigma-Aldrich PHR2305 Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material 2942-59-8 50MG $466 2022-05-15 Buy
Sigma-Aldrich 1274629 Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard 2942-59-8 15mg $1370 2022-05-15 Buy
TCI Chemical C1108 2-Chloronicotinic Acid >98.0%(HPLC)(T) 2942-59-8 25g $19 2023-01-07 Buy
TCI Chemical C1108 2-Chloronicotinic Acid >98.0%(HPLC)(T) 2942-59-8 250g $90 2023-01-07 Buy
Product number Packaging Price Buy
150339 10g $47.6 Buy
PHR2305 50MG $466 Buy
1274629 15mg $1370 Buy
C1108 25g $19 Buy
C1108 250g $90 Buy

2-Chloronicotinic acid Chemical Properties,Uses,Production

Chemical Properties

white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.


2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.


2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.


Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.


ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.

Synthesis of 2-Chloronicotinic acid from 2-CHLORO-3-ETHYL PYRIDINE
Global( 853)Suppliers
Supplier Tel Email Country ProdList Advantage
CD Chemical Group Limited
+8615986615575 China 20356 58
Hubei Ipure Biology Co., Ltd
+8618062405514 China 10339 58
Nanjing Hengbei Chemicals Co., Ltd.
+86-25-58393656 China 6856 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21975 55
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106 China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29810 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 18267 58
Jiangsu Zhongbang Pharmaceutical Co., Ltd.
025-87151996 CHINA 32 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 China 1807 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9407 55

View Lastest Price from 2-Chloronicotinic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloronicotinic acid pictures 2023-05-26 2-Chloronicotinic acid
US $0.00 / KG 1KG 99% 500mt Jinan Finer Chemical Co., Ltd
2-Chloronicotinic acid pictures 2023-05-19 2-Chloronicotinic acid
US $0.00 / kg 25kg 99% 200mt AS WATER CO., LTD.
2-Chloronicotinic acid pictures 2023-04-20 2-Chloronicotinic acid
US $1.00 / mg 100mg 98.0% 5ton/month ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
TIMTEC-BB SBB004002 2-chloro-3-pyridinecarboxylicaci 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID 2CLNA 2-CHLORONICOTINIC ACID RARECHEM AL BO 0287 AKOS BBS-00004231 2-Chloronicotinic Aicd 2-Chloropyridine-3-carboxylic acid, 3-Carboxy-2-chloropyridine 2-chlorine nicotinic acid 2 - chloro niacin 2-Chloronicoti 2-Chloronicotinic acid 2-Chloro-3-pyridinecarboxylic acid 2-Chloropyridine-3-carboxylic acid 99% Flunixin Related CoMpound A 2-CHLORO-3-CARBOXYLPYRIDINE 2-Chloropyridine-3-carboxylic 2-Chloronicotinic acid 98% 2-Chloro Nicotinc Acid 3-Pyridinecarboxylic acid, 2-chloro- 2-ChloroNicotinicAcid,99%-100.5% 2-CHLORO-3-PYRIDINECARBOXYLIC ACID / 2-CHLORONICOTINIC ACID 2-CHLORONICOTINIC ACID 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID 2-CHLORONITINICACID 2-Chloropyridine-3-carboxylic acid,2-Chloronicotinic acid 2-Chloronicotinic ac 2-chloro-3-picolinate Flunixin Meglumine Impurity 1(Flunixin Meglumine EP Impurity A) oronicotinic acid Flunixin Meglumine EP Impurity A 2-Chloronicotinic Acid > Niflumic acid impurity A CRS 2-Chlornicotinsaeure Niflumic Acid EP Impurity A Flunixin EP Impurity A 2 - nicotinic acid chloride Flunixin impurity AQ: What is Flunixin impurity A Q: What is the CAS Number of Flunixin impurity A Q: What is the storage condition of Flunixin impurity A Q: What are the applications of Flunixin impurity A Flunixin Related Compound A (2-Chloronicotinic acid) (1274629) 2-CHLORO-3-PYRIDINECARBOXYLIC ACID 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID CHLORONICOTINIC ACID Flunixin USP Related Compound A 2-Chloronicotinic acidedione Flunixin Meglumine Impurity 3 2942-59-8 2492-59-8 Pyridines Halogenated Heterocycles Heterocyclic Building Blocks Halopyridines Chloropyridines Building Blocks ACID pyridine series blocks Carboxes Pyridines Pyridine