Boc-L-Pyroglutamic acid methyl ester
- CAS No.
- 108963-96-8
- Chemical Name:
- Boc-L-Pyroglutamic acid methyl ester
- Synonyms
- (S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate;BOC-PYR-OME;(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE;1-tert-Butyl 2-Methyl (2S)-5-Oxopyrrolidine-1,2-dicarboxylate;utamate;Boc-pGlu-OMe;BOC-L-Pyr.Ome;Boc-Pyr-OMe 99%;Boc-L-Pyroglutamic a;Methyl (L)-N-Boc-pyroglu
- CBNumber:
- CB7717837
- Molecular Formula:
- C11H17NO5
- Molecular Weight:
- 243.26
- MDL Number:
- MFCD06809720
- MOL File:
- 108963-96-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-Pyr-OMe 97% | 757497 | 1g | $33 |
| Methyl (S)-Boc-5-pyrrolidone-2-carboxylate 97% | 738182 | 1g | $40.4 |
| Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate >98.0%(GC) | M2803 | 5g | $55 |
| Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate >98.0%(GC) | M2803 | 25g | $190 |
| Methyl(2S)-1-(tert-butoxycarbonyl)pyroglutamate | M294429 | 5g | $115 |
| More product size | |||
| Melting point | 68-72 °C 69-74 °C |
|---|---|
| Boiling point | 361.6±35.0 °C(Predicted) |
| Density | 1.209±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in dichloromethane. |
| pka | -4.28±0.40(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| optical activity | [α]22/D 32.0°, c = 0.5 in chloroform &_& [α]22/D -32°, c = 0.5% in chloroform |
| InChI | InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m0/s1 |
| InChIKey | FNTAOUUEQHKLIU-ZETCQYMHSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C(=O)CC[C@H]1C(OC)=O |
| CAS DataBase Reference | 108963-96-8(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 36-43-50 | |||||||||
| Safety Statements | 26-36/37-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
|||||||||
| NFPA 704 |
|
Boc-L-Pyroglutamic acid methyl ester price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 757497 | Boc-Pyr-OMe 97% | 108963-96-8 | 1g | $33 | 2023-06-20 | Buy |
| Sigma-Aldrich | 738182 | Methyl (S)-Boc-5-pyrrolidone-2-carboxylate 97% | 108963-96-8 | 1g | $40.4 | 2023-01-07 | Buy |
| TCI Chemical | M2803 | Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate >98.0%(GC) | 108963-96-8 | 5g | $55 | 2026-03-19 | Buy |
| TCI Chemical | M2803 | Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate >98.0%(GC) | 108963-96-8 | 25g | $190 | 2026-03-19 | Buy |
| TRC | M294429 | Methyl(2S)-1-(tert-butoxycarbonyl)pyroglutamate | 108963-96-8 | 5g | $115 | 2021-12-16 | Buy |
Boc-L-Pyroglutamic acid methyl ester Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Solid
Uses
Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate in medicine, pharmacy, cosmetics, and industrial, artificial flavoring and fragrance agents
Synthesis
67-56-1
24424-99-5
98-79-3
108963-96-8
(1) Synthesis of (2S)-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (Compound 3): L-pyroglutamic acid (15.0 g) was suspended in methanol (60.0 mL), and thionyl chloride (27.6 g) was slowly added with stirring at a temperature lower than 30°C. The reaction was completed after 1 hour by HPLC. After 1 hr of reaction, HPLC monitoring showed completion of the reaction. The solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (200 mL). Triethylamine (13.5 g) was slowly added at a temperature below 30 °C, followed by filtration of the mixture. To the filtrate was added DMAP (1.5 g) in a single addition, followed by di-tert-butyl dicarbonate (Boc2O, 27.8 g) at a temperature below 30 °C. After HPLC monitoring showed the reaction to be complete, the mixture was cooled to 0 °C and 1N HCl (13.0 mL) was added and stirred at a temperature below 30 °C for 10 min. The organic layer was separated, washed with H2O (20.0 mL) and the solvent was evaporated under reduced pressure. To the resulting residue was added tert-butyl methyl ether (27.0 mL) and cooled to 0°C with stirring. The slowly precipitated crystals were filtered to give compound 3 (21.9 g, 77.3% yield).
References
[1] Patent: WO2010/9014, 2010, A2. Location in patent: Page/Page column 6
[2] Patent: CN106336371, 2017, A. Location in patent: Paragraph 0050; 0051
Boc-L-Pyroglutamic acid methyl ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Baishixing Science and Technology Industry Co.,Ltd | +86-15008457246 | yuki@cd-bsx.com | China | 53 | 58 |
| Dingwang Technology (Wuhan) Co., Ltd. | +undefined-27-2786652399 +undefined13627115097 | market02@senwayer.com | China | 888 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1098 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from Boc-L-Pyroglutamic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-29 | Boc-L-Pyroglutamic acid methyl ester
108963-96-8
|
US $0.00 / KG | 1KG | 99% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-04-29 | Boc-L-Pyroglutamic acid methyl ester
108963-96-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-11-19 | Boc-L-Pyroglutamic acid methyl ester
108963-96-8
|
US $0.00 / kg | 1kg | 99% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- Boc-L-Pyroglutamic acid methyl ester
108963-96-8
- US $0.00 / KG
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Boc-L-Pyroglutamic acid methyl ester
108963-96-8
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-L-Pyroglutamic acid methyl ester
108963-96-8
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
