4,6-DIMETHYL-2-NITROANILINE
- CAS No.
- 1635-84-3
- Chemical Name:
- 4,6-DIMETHYL-2-NITROANILINE
- Synonyms
- 6-nitro-2,4-xylidine;4,6-DIMETHYL-2-NITROANILINE;2,4-Dimethyl-6-nitroBenzenamine;2,4-Dimethyl-6-nitroaniline 97%;2,4-Dimethyl-6-nitroaniline, 97%;4,6-Dimethyl-2-nitroaniline, 97%,;Benzenamine, 2,4-dimethyl-6-nitro-;5-NITRO-4-AMINO-1,3-DIMETHYLBENZENE;1-(2-methylpropyl)pyrrolidine-2,5-dione;4,6-DIMETHYL-2-NITROANILINE, TECH., 90%
- CBNumber:
- CB7718526
- Molecular Formula:
- C8H10N2O2
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD00007739
- MOL File:
- 1635-84-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,4-Dimethyl-6-nitroaniline | D465715 | 10g | $360 |
| (2,4-Dimethyl-6-nitrophenyl)amine | FD133701 | 10g | $609 |
| 4,6-DIMETHYL-2-NITROANILINE 95.00% | CHM0025024 | 1G | $650.27 |
| 4,6-DIMETHYL-2-NITROANILINE 95.00% | CHM0025024 | 5G | $939.94 |
| (2,4-Dimethyl-6-nitrophenyl)amine | FD133701 | 5G | $358 |
| More product size | |||
| Melting point | 64-68 °C(lit.) |
|---|---|
| Boiling point | 319.1±37.0 °C(Predicted) |
| Density | 1.220±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| pka | 0.27±0.25(Predicted) |
| Appearance | Yellow to orange Solid |
| FDA UNII | ZF8VRN3SKA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H302-H312-H332-H331 | |||||||||
| Precautionary statements | P304+P340-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214990 | |||||||||
| NFPA 704 |
|
4,6-DIMETHYL-2-NITROANILINE price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D465715 | 2,4-Dimethyl-6-nitroaniline | 1635-84-3 | 10g | $360 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD133701 | (2,4-Dimethyl-6-nitrophenyl)amine | 1635-84-3 | 10g | $609 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0025024 | 4,6-DIMETHYL-2-NITROANILINE 95.00% | 1635-84-3 | 1G | $650.27 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0025024 | 4,6-DIMETHYL-2-NITROANILINE 95.00% | 1635-84-3 | 5G | $939.94 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD133701 | (2,4-Dimethyl-6-nitrophenyl)amine | 1635-84-3 | 5G | $358 | 2021-12-16 | Buy |
4,6-DIMETHYL-2-NITROANILINE Chemical Properties,Uses,Production
Uses
2,4-Dimethyl-6-nitroaniline is used as a reagent in the synthetic preparation of 1,2-bis-substituted benzimidazoles as nonnucleoside HIV-1 reverse transcriptase inhibitors.
Synthesis
95-68-1
1635-84-3
General procedure for the synthesis of 2-nitro-4,6-dimethylaniline from 2,4-dimethylaniline: 2,4-dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL) and concentrated nitric acid (5 mL) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and then diluted with ice water (200 mL). Subsequently, concentrated hydrochloric acid (10 mL) was added dropwise to the mixture and the resulting mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was diluted with aqueous ammonium hydroxide and the resulting orange solid was filtered and dried to give 2-nitro-4,6-dimethylaniline (10.6 g, 97% yield).
References
[1] Patent: WO2009/25478, 2009, A1. Location in patent: Page/Page column 33; 52-53
[2] Patent: US2010/197673, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: KR101511771, 2015, B1. Location in patent: Paragraph 0406; 0407
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 10, p. 1267 - 1273
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8743 - 8749
4,6-DIMETHYL-2-NITROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20284 | 58 |
View Lastest Price from 4,6-DIMETHYL-2-NITROANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-08-12 | 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-12 | 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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