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Formoterol

Formoterol structure

CAS No.: 73573-87-2

Chemical Name:: Formoterol

Synonyms: FORMOTEROL TARTRATE;Oxis;FORMOTEROL;Formoteral;Eformoterol;FormoterolBase;1-nitrotridec-1-ene;Formoterol Standard;FORMOTEROL TARTARATE;Formoterol USP/EP/BP

CBNumber:: CB7722411

Molecular Formula:: C19H24N2O4

Molecular Weight:: 344.4

MDL Number:: MFCD05662345

MOL File:: 73573-87-2.mol

Last updated:2024-03-19 15:37:50

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Formoterol Properties

Boiling point	603.2±55.0 °C(Predicted)
Density	1.233±0.06 g/cm3(Predicted)
solubility	DMSO: 20 mg/mL, soluble
form	solid
pka	8.95±0.50(Predicted)
color	off-white
Stability	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	73573-87-2(CAS DataBase Reference)
FDA UNII	5ZZ84GCW8B
ATC code	R03AC13

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H362-H361
Precautionary statements	P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
WGK Germany	3

Formoterol price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Medical Isotopes, Inc.	CD33990	Formoterol-13C-d3	73573-87-2	1mg	$660	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0034798	FORMOTEROL TARTRATE 95.00%	73573-87-2	100MG	$885.31	2021-12-16	Buy
AvaChem	2256B	Formoterol	73573-87-2	1g	$980	2021-12-16	Buy
AvaChem	2256B	Formoterol	73573-87-2	100mg	$269	2021-12-16	Buy

Product number	Packaging	Price	Buy
CD33990	1mg	$660	Buy
CHM0034798	100MG	$885.31	Buy
2256B	1g	$980	Buy
2256B	100mg	$269	Buy

Formoterol Chemical Properties,Uses,Production

Description

Formoterol is a potent bronchoselective β-agonist with long duration of action given by inhalation.

Chemical Properties

solid

Uses

Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.

Uses

Formoterol is a useful compound for treating respiratory obstructive diseases.

Definition

ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.

brand name

Foradil (Novartis).

General Description

Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.

Mechanism of action

Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.

Formoterol Preparation Products And Raw materials

Raw materials

FORMOTEROL INTERMEDIATE Benzenemethanol, 3-amino-α-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-4-(phenylmethoxy)-, (αR)- 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone (R)-1-(4-Benzyloxy-3-nitrophenyl)-2-bromoethanol 1316100-17-0

1-(4-METHOXYPHENYL)-2-NITROPROPENE (R)-N-(2-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide Oxirane, [3-nitro-4-(phenylMethoxy)phenyl]-, (2R)- 4-Benzyloxy-3-nitroacetophenone Formoterol Impurity

N-(2-(benzyloxy)-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)phenyl)forMaMide 1-(4-Methoxyphenyl)-2-benzylaminopropane (R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane 4-Methoxyphenylacetone

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Preparation Products

Formoterol Suppliers

Global( 110)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15747	58
Shanghai Quedan biology science and technology co., ltd	+86-13004146052	lnzc@quedan.com.cn	China	1060	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Healthchem co.,ltd	58
changzhou huayang technology co., ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hebei Duling International Trade Co. LTD	58
Shanghai Quedan biology science and technology co., ltd	58

View Lastest Price from Formoterol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide 73573-87-2	US $1.00 / kg	1kg	99%	Customized	Career Henan Chemical Co

N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
73573-87-2
US $1.00 / kg
99%
Career Henan Chemical Co

73573-87-2(Formoterol)Related Search:

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n-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide FORMOTEROL TARTARATE FormoterolBase Formoterol Fumarate 43229-80-7 / Base Eformoterol Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)- Oxis N-[2-Hydroxy-5-[1(R)-hydroxy-2-[[2-(4-methoxyphenyl)-1(R)-methylethyl] amino]ethyl]phenyl]formamide FORMOTEROL rel-N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)phenyl)forMaMide N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide 1-nitrotridec-1-ene Formoterol USP/EP/BP Formoterol (10mM in DMSO) Formoteral FORMOTEROL TARTRATE Formoterol Standard 73573-87-2 C19H24N2O4 Other APIs Inhibitors (intermediates of formoterol ) API