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4-Chloropyridine-2-carboxamide

4-Chloropyridine-2-carboxamide structure

CAS No.: 99586-65-9

Chemical Name:: 4-Chloropyridine-2-carboxamide

Synonyms: KML-49;RG-S1-XA;4-Chloropicolimide;IFLAB-BB F2108-0034;4-CHLOROPICOLINAMIDE;4-Chloropyridine-2-c;4-CHLOROPHCOLINAMIDE;4-Chloro-2-picolinamide;4-Chloropyridine-2-formamide;Sorafenib tosylate Impurity 1

CBNumber:: CB7736780

Molecular Formula:: C6H5ClN2O

Molecular Weight:: 156.57

MDL Number:: MFCD01085339

MOL File:: 99586-65-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:24:39

Product description	Number	Pack Size	Price
4-Chloro-pyridine-2-carboxylic acid amide Aldrich	ADE000335	1g	$497
4-Chloropyridine-2-carboxamide >97.0%(HPLC)(T)	C2949	1g	$18
4-Chloropyridine-2-carboxamide >97.0%(HPLC)(T)	C2949	5g	$69
4-Chloropyridine-2-carboxamide	C381475	50g	$470
4-Chloropyridine-2-carboxamide	J96813	5g	$14
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4-Chloropyridine-2-carboxamide Properties

Melting point	148-152
Boiling point	298.1±25.0 °C(Predicted)
Density	1.381±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	14.49±0.50(Predicted)
form	Solid
color	Off-white
λmax	268nm(EtOH)(lit.)
InChI	InChI=1S/C6H5ClN2O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,8,10)
InChIKey	XIHHOUUTBZSYJH-UHFFFAOYSA-N
SMILES	C1(C(N)=O)=NC=CC(Cl)=C1
CAS DataBase Reference	99586-65-9(CAS DataBase Reference)
UNSPSC Code	12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317

Precautionary statements

P280

Hazard Codes

Xi,Xn

Risk Statements

HazardClass

IRRITANT

HS Code

2933399990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Skin Sens. 1

NFPA 704

	1
2		0

4-Chloropyridine-2-carboxamide price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000335	4-Chloro-pyridine-2-carboxylic acid amide Aldrich	99586-65-9	1g	$497	2025-07-31	Buy
TCI Chemical	C2949	4-Chloropyridine-2-carboxamide >97.0%(HPLC)(T)	99586-65-9	1g	$18	2025-07-31	Buy
TCI Chemical	C2949	4-Chloropyridine-2-carboxamide >97.0%(HPLC)(T)	99586-65-9	5g	$69	2025-07-31	Buy
TRC	C381475	4-Chloropyridine-2-carboxamide	99586-65-9	50g	$470	2021-12-16	Buy
AK Scientific	J96813	4-Chloropyridine-2-carboxamide	99586-65-9	5g	$14	2021-12-16	Buy

Product number	Packaging	Price	Buy
ADE000335	1g	$497	Buy
C2949	1g	$18	Buy
C2949	5g	$69	Buy
C381475	50g	$470	Buy
J96813	5g	$14	Buy

4-Chloropyridine-2-carboxamide Chemical Properties,Uses,Production

Chemical Properties

4-Chloropyridine-2-carboxamide has active reactivity and special solvation ability, and can undergo dehydration, de-CO, introduction of amino groups, introduction of acyl groups, and cyclization in addition to the reaction involving three hydrogens].

Uses

4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.

Synthesis

5470-22-4

99586-65-9

General procedure for the synthesis of 4-chloropyridine-2-carboxamide from 4-chloropyridine-2-carboxylic acid: a non-homogeneous mixture formed by 4-chloropyridine-2-carboxylic acid (TCI America, 5.4 g, 34.2 mmol, 1.0 equiv.) and thionyl chloride (30 mL) was heated and refluxed for 2 hr at 80 °C. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove excess thionyl chloride. The resulting residue was placed in an ice bath and a methanol solution of ammonia (7 N, 45 mL) was slowly added and stirred under ice bath conditions for 15 minutes. The ice bath was then removed and the reaction mixture was allowed to gradually warm up to room temperature and stirring was continued for 3 hours. At the end of the reaction, the solvent was removed by concentration under reduced pressure and the residue was purified by recrystallization from ethyl acetate to afford the target product 4-chloropyridine-2-carboxamide (5.14 g, 96% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 8.61-8.63 (m, 1H), 8.21 (m, 1H), 8.03-8.04 (m, 1H), 7.76-7.83 (m, 2H); the mass spectrum (ESI+) showed m/z 157 ([M+H]+).

References

[1] Patent: US2005/245530, 2005, A1. Location in patent: Page/Page column 39
[2] Patent: US2007/78140, 2007, A1. Location in patent: Page/Page column 25
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 14, p. 4323 - 4329
[4] Patent: WO2014/22116, 2014, A2. Location in patent: Paragraph 0212
[5] Patent: US2015/37280, 2015, A1. Location in patent: Paragraph 0414

4-Chloropyridine-2-carboxamide Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Nitrogen Sodium bromide Calcium chloride Sodium

Tetrahydrofuran Ethyl acetate Sodium hydroxide 2-Picolinic acid Thionyl chloride

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Preparation Products

4-CHLORO-PYRIDINE-2-CARBONITRILE N-amino-4-chloropyridine-2-carboximidamide

4-Chloropyridine-2-carboxamide Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025	sales@ryanchem.com	China	169	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58

View Lastest Price from 4-Chloropyridine-2-carboxamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	4-CHLOROPYRIDINE-2-CARBOXAMIDE 99586-65-9	US $0.00 / g	1g	98%	20tons	Hubei Lidu New Material Technology Co., Ltd
2025-11-18	4-Chloropyridine-2-carboxamide 99586-65-9	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2019-07-14	4-Chloropyridine-2-carboxamide 99586-65-9	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

4-CHLOROPYRIDINE-2-CARBOXAMIDE
99586-65-9
US $0.00 / g
98%
Hubei Lidu New Material Technology Co., Ltd

4-Chloropyridine-2-carboxamide
99586-65-9
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-Chloropyridine-2-carboxamide
99586-65-9
US $1.00 / KG
99%
Career Henan Chemical Co

4-Chloropyridine-2-carboxamide Spectrum

4-Chloropyridine-2-carboxamide(99586-65-9)¹HNMR

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4-Chloro-2-picolinamide 4-Chloropyridine-2-carboxamide ,95% 4-Chloropyridine-2-c 2-PyridinecarboxaMide,4-chloro 4-Chloropicolinamide, 2-Carbamoyl-4-chloropyridine IFLAB-BB F2108-0034 4-CHLOROPICOLINAMIDE 4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID AMIDE 4-CHLOROPYRIDINE-2-CARBOXAMIDE 4-CHLORO-2-PYRIDINECARBOXAMIDE 4-Chloropyridine-2-carboxamide 98% 4-CHLOROPHCOLINAMIDE 4-chloropyridin-2-carboxyamide 4-Chloropyridine-2-carboxamide > 4-Chloropyridine-2-carboxamide ISO 9001：2015 REACH Sorafenib tosylate Impurity 1 KML-49 RG-S1-XA 4-Chloropyridine-2-formamide 4-Chloropicolinamide (4-Chloropyridine-2-carboxamide) 4-chloropyridine-2-carboxylate 4-Chloropicolimide 99586-65-9 C6H5ClN2O C6H5CIN2O blocks Carboxes Pyridines Pyridine series Pyridine 12-2