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tert-Butyl chloroacetate

tert-Butyl chloroacetate structure

CAS No.: 107-59-5

Chemical Name:: tert-Butyl chloroacetate

Synonyms: 153N-6;NSC 87891;ClCH2C(O)OC(CH3)3;(10E)-3-O-De(αtert-Butyl chloroace;T-BUTYL CHLOROACETATE;TERT-BUTYL CHLORACETATE;3-Formyl Tyrosol αreft-Butyl chloroacetate;TERT-BUTYL CHLOROACETATE

CBNumber:: CB7749461

Molecular Formula:: C6H11ClO2

Molecular Weight:: 150.6

MDL Number:: MFCD00000930

MOL File:: 107-59-5.mol

MSDS File:: SDS

Last updated:2023-10-13 18:16:27

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tert-Butyl chloroacetate Properties

Boiling point	48-49 °C/11 mmHg (lit.)
Density	1.053 g/mL at 25 °C (lit.)
refractive index	n20/D 1.423(lit.)
Flash point	116 °F
storage temp.	Flammables area
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.053
Water Solubility	<0.1 g/L (20 ºC)
Merck	14,1563
BRN	1753006
LogP	2.07
CAS DataBase Reference	107-59-5(CAS DataBase Reference)
FDA UNII	05TMW98298
NIST Chemistry Reference	Acetic acid, chloro-, 1,1-dimethylethyl ester(107-59-5)
EPA Substance Registry System	Acetic acid, chloro-, 1,1-dimethylethyl ester (107-59-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS02,GHS05,GHS06,GHS09

Signal word

Danger

Hazard statements

H302+H312+H332-H315-H319-H302-H312-H335-H400-H410-H226-H302+H312-H314-H331

Precautionary statements

P273-P280h-P309-P501a-P261-P280-P305+P351+P338-P310-P210-P233-P240-P241+P242+P243-P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501

Hazard Codes

C,N,Xn,Xi,F

Risk Statements

20/21/22-34-50/53-36/37/38-10

Safety Statements

26-36/37/39-45-61-60-16-7/9

RIDADR

UN 2920 8/PG 2

WGK Germany

RTECS

AF8985500

19-21

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29154000

Toxicity

rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000.

NFPA 704

	2
3		0

tert-Butyl chloroacetate price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	186791	tert-Butyl chloroacetate 97%	107-59-5	25g	$46.8	2024-03-01	Buy
Sigma-Aldrich	186791	tert-Butyl chloroacetate 97%	107-59-5	100g	$83.2	2024-03-01	Buy
TCI Chemical	C1267	tert-Butyl Chloroacetate >97.0%(GC)	107-59-5	25mL	$33	2024-03-01	Buy
TCI Chemical	C1267	tert-Butyl Chloroacetate >97.0%(GC)	107-59-5	500mL	$94	2024-03-01	Buy
Alfa Aesar	A15833	tert-Butyl chloroacetate, 98%	107-59-5	25g	$26.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
186791	25g	$46.8	Buy
186791	100g	$83.2	Buy
C1267	25mL	$33	Buy
C1267	500mL	$94	Buy
A15833	25g	$26.65	Buy

tert-Butyl chloroacetate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.

Uses

tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.

Uses

In the glycidic ester condensation.

Preparation

tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.

Safety Profile

A poison by ingestion. Moderately toxic by inhalation skin contact. S severe sluin and moderate eye irritant. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]

tert-Butyl chloroacetate Preparation Products And Raw materials

Raw materials

Chloroacetyl chloride

Preparation Products

tert-Butyl cyanoacetate 3-Chlorophenoxyacetic acid 2-T-BUTYL GLYCOLATE tert-Butyl 2-mercaptoacetate tert-Butyl sarcosinate hydrochloride

tetra-tert-butyl 2,2',2'',2'''-((((2-(tert-butoxy)-2-oxoethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetate ACEMETACINTERT-BUTYLESTER 2-Thiophenecarboxylic acid, 3-amino-4-cyclopropyl-, 1,1-dimethylethyl ester Aceclofenac tert-butyl ester

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tert-Butyl chloroacetate Suppliers

Global( 339)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	dave@jxswchem.com	China	22	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Kingfirst chemical (nanjing) co.,ltd	86-25-84522992	marketing@kingfirstchem.com	CHINA	95	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58

Supplier	Advantage
Jiangxi Sunway Chemical Co., Ltd.	58
Jiangxi Sunway Chemical Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Kingfirst chemical (nanjing) co.,ltd	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from tert-Butyl chloroacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	tert-Butyl chloroacetate 107-59-5	US $0.00 / KG	1KG	99%	1000mt/year	Jinan Finer Chemical Co., Ltd
2023-10-14	tert-Butyl chloroacetate 107-59-5	US $0.00 / kg	1kg	0.985	20tons	Hebei Yanxi Chemical Co., Ltd.
2023-08-18	tert-Butyl chloroacetate 107-59-5	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

tert-Butyl chloroacetate
107-59-5
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

tert-Butyl chloroacetate
107-59-5
US $0.00 / kg
0.985
Hebei Yanxi Chemical Co., Ltd.

tert-Butyl chloroacetate
107-59-5
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

tert-Butyl chloroacetate Spectrum

tert-Butyl chloroacetate(107-59-5)MS tert-Butyl chloroacetate(107-59-5)¹HNMR tert-Butyl chloroacetate(107-59-5)¹³CNMR tert-Butyl chloroacetate(107-59-5)IR1 tert-Butyl chloroacetate(107-59-5)Raman

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Acetic acid, chloro-, tert-butyl ester aceticacid,chloro-,1,1-dimethylethylester ClCH2C(O)OC(CH3)3 tert-Butyl chloroacetate,97% tert-Butyl chloroacetate,99% tert-Butyl chloroace tert-Butyl chloroacetate, 97% 100GR NSC 87891 ChloroaceticAcidtert-ButylEste (InterMediate of Tert-Butyl Rosuvastatin) Aceticacid, 2-chloro-, 1,1-diMethylethyl ester tert-Butyl chloroacetate, 98+% 1,1-Dimethylethyl chloroacetate Chloroacetic acid 1,1-dimethylethyl ester Chloroacetic acid 1,1-dimethylethyl reft-Butyl chloroacetate T-BUTYL CHLOROACETATE TERT-BUTYL CHLORACETATE TERT-BUTYL CHLOROACETATE CHLOROACETIC ACID T-BUTYL ESTER CHLOROACETIC ACID TERT-BUTYL ESTER #ntert.-Butyl chloroacetate 1,4-Dimethyl-5H-pyrido[4,3-β]indol-3-amine-13C,15N Monoacetate 3-Amino-1,4-dimethyl-5h-pyrido[4,3-β]indole-13C2,15N Acetate Tert butyl chloro acetic acid -L-cladinose)-10-dehydro-11-dehydroxy-6-O-methyl-erythromycin 153N-6 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 MPFRWFKPV-NH2 MET-PRO-D-PHE-ARG-D-TRP-PHE-LYS-PRO-VAL-NH2MPFRWFKPV-NH2;153N-6;L-METHIONYL-L-PROLYL-D-PHENYLALANYL-L-ARGINYL-D-TRYPTOPHYL-L-PHENYLALANYL-L-LYSYL-L-PROLYL-L-VALINAMIDE; ACETATE 3-Formyl Tyrosol &alpha 4-O-Benzyl-3-acetyloxy Tyrosol &alpha (10E)-3-O-De(&alpha tert-Butyl Chloroacetate > 107-59-5 (TERT-BUTYL CHLOROACETATE) tert-Butyl Chloroacetate, ≥ 97.0% 107-59-5 54512-75-2 C1313C2H17N215NO2 C6H11ClO2 ClCH2CO2CCH33 ACETATE Esters Organic Building Blocks C6 to C7 Carbonyl Compounds Building Blocks Pharmaceutical intermediates API Intermediate API intermediates C6 to C7 Carbonyl Compounds Esters K00001