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Organic reagents Chemical properties Uses Production method
Thioacetamide structure
Chemical Name:
TAA;CH3CSNH2;usafcb-21;USAF cb-21;usafek-1719;Thiacetamide;hioacetamide;Thioactamide;USAF ek-1719;Ahioacetamide
Molecular Formula:
Formula Weight:
MOL File:

Thioacetamide Properties

Melting point:
108-112 °C(lit.)
refractive index 
1.5300 (estimate)
storage temp. 
Store at RT.
passes test2%
Off-white to slightly beige
5.2 (100g/l, H2O, 20℃)
Water Solubility 
16.3 g/100 mL (25 ºC)
Stability Incompatible with water, mineral acids.
CAS DataBase Reference
62-55-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H341-H351-H371-H372-H302-H315-H319-H350-H412
Precautionary statements  P301+P312a-P501a-P202-P260-P264-P270-P308+P311-P405-P501-P201-P280-P301+P312+P330-P305+P351+P338-P308+P313-P273
Hazard Codes  T
Risk Statements  45-22-36/38-52/53
Safety Statements  53-45-61-99
RIDADR  2811
WGK Germany  3
RTECS  AC8925000
HS Code  29309070
Toxicity MLD orally in rats: 200 mg/kg (Ambrose)

Thioacetamide price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 163678 Thioacetamide ACS reagent, ≥99.0% 62-55-5 25g $56.5 2018-11-13 Buy
Sigma-Aldrich 163678 Thioacetamide ACS reagent, ≥99.0% 62-55-5 100g $149 2018-11-13 Buy
TCI Chemical T0187 Thioacetamide >98.0%(GC)(T) 62-55-5 25g $18 2018-11-22 Buy
TCI Chemical T0187 Thioacetamide >98.0%(GC)(T) 62-55-5 100g $52 2018-11-22 Buy
Alfa Aesar 030638 Thioacetamide, ACS, 99% 62-55-5 10g $18.7 2018-11-16 Buy

Thioacetamide Chemical Properties,Uses,Production

Organic reagents

Thioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is:
Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S
Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS-
Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4.

Chemical properties

It is colorless or white crystals. Mp is 113-114℃, the solubility in water is 16.3g/100ml at 25℃, ethanol 26.4g/100ml. It is slightly soluble in benzene, ether. Their solution is quite stable at room temperature or 50-60℃, but when hydrogen ions exists, it can generate thiosulfate hydrogen and decompose quickly. New product sometimes has mercaptan odor, slight moisture absorption.
The above information is edited by the chemicalbook of Wang Xiaodong.


1. It can be used for the production of catalysts, stabilizers, polymerization inhibitors, electroplating additives, photographic chemicals, pesticides, dyeing auxiliary and processing agents. It can be also used as polymer curing agents, crosslinking agents, rubber additives and pharmaceutical raw materials.
2. It can be also used as vulcanizing agent and crosslinking agent of polymer, rubber additives, pharmaceutical raw materials, etc.
3. It can be also used as analytical reagents.

Production method

Thioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide.

Chemical Properties

White solid

Chemical Properties

Thioacetamide is combustible, crystalline compound. Slight mercaptan odor.


It is used as an intermediate in organicsynthesis.


Sulfide generation


Substitute for H2S in laboratory qualitative analyses.


ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.

General Description

White crystals with a mercaptan odor.

Air & Water Reactions

Slightly water soluble.

Reactivity Profile

Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .


Toxic by ingestion and inhalation, a possible carcinogen.

Health Hazard

The toxicity of this compound is moderatein rats; an oral lethal dose is 200 mg/kg.Oral administration of thioacetamide causedliver cancer in rats and mice. It is, however, a weak liver carcinogen. Malvaldi and associates (1988) investigated the mechanism of its carcinogenic activity on rat liver.Whereas the initiating ability of this compound is quite low, its promoting effect isstrong. Thus thioacetamide is a very effectivepromoter of the liver carcinogenesis. A similar promoting activity of liver carcinogenesishas been observed with other thioamide substances, such as thiobenzamide (Malvaldi et al. 1986).
Low et al. (2004) have proposed a modelto explain thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. The pathways of thioacetamide-induced liver fibrosiswere found to be initiated by thioacetamideS-oxide derived from the biotransformationof thioacetamide by the microsomal flavinadenine nucleotide containing monooxygenase and cytochrome P450 systems andinvolve oxidative stress and depletion ofsuccinyl-CoA, thus affecting heme and ironmetabolism. Karabay et al. (2005) observedsuch hepatic damage in rats with elevationof total nitrite level in livers and decrease inarginase activity. The authors have reportedthat nitrosative stress was essentially the critical factor in thioacetamide-induced hepaticfailure in rats.
Pretreatment of rats with jigrine exhibited hepatoprotective action againstthioacetamide-induced toxicity (Ahmed et al.1999). Thioacetamide decreased the concentration of glutathione in the liver of rats.Jigrine pretreatment, however, restored theglutathione levels to the near normal values.The authors claimed that the effects of jigrinewere comparable to that of silymarin. Thehepatotoxicity in rats was found to potentiatefollowing pretreatment with phenobarbital.
Al-Bader et al. (2000) investigated thetoxicity of thioacetamide in the spleen inexperimental animals. The authors foundan intimate association between the levelsof trace metals and spleen pathology, asobserved in studies of other organs.

Fire Hazard

Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES and MERCAPTANS.

Potential Exposure

Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel.


Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.]


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.


Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 10 lb.
Emergency Planning and Community Right-To-Know Act
Toxics Release Inventory: Listed substance subject to reporting requirements.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of thioacetamide = U218.
Listed as a hazardous constituent of waste.

Thioacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Thioacetamide Suppliers

Global( 332)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897093 CHINA 146 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21672 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1861 55
career henan chemical co
+86-371-86658258 CHINA 30003 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872 CHINA 556 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58

View Lastest Price from Thioacetamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-13 Thioacetamide 62-55-5 In stock Ethanethioamide
US $1.50-1.10 / KG 1KG 99.5% high quality purified in stock bulk metric tons per month Chemwill Asia Co.,Ltd.
2019-07-13 Thioacetamide 62-55-5 Manufacturer High quality Best price In stock Ethanethioamide 62-55-5
US $2.10-1.65 / KG 1KG 99.5% high quality purified in stock bulk metric tons per month Chemwill Asia Co.,Ltd.
2019-05-28 Thioacetamide manufacturer kf-wang(at)
US $10.00 / Kg/Drum 1g 99.8% 2000 Hebei Aicrowe Biotech Co., Ltd

Thioacetamide Spectrum

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