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2'-FLUORO-6'-HYDROXYACETOPHENONE

2'-FLUORO-6'-HYDROXYACETOPHENONE structure

CAS No.: 93339-98-1

Chemical Name:: 2'-FLUORO-6'-HYDROXYACETOPHENONE

Synonyms: 2-FLUORO-6-HYDROXYACETOPHENONE;2'-Fluoro-6'-hydroxyacetophenone;1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE;1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one;Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-;1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol

CBNumber:: CB7757152

Molecular Formula:: C8H7FO2

Molecular Weight:: 154.14

MDL Number:: MFCD01090995

MOL File:: 93339-98-1.mol

Last updated:2025-07-24 18:13:53

Product description	Number	Pack Size	Price
1-(2-Fluoro-6-hydroxyphenyl)ethanone	F598130	10mg	$45
2'-Fluoro-6'-hydroxyacetophenone	2620-3-X7	1g	$93
2'-Fluoro-6'-hydroxyacetophenone	PC9896	5g	$254
2'-Fluoro-6'-hydroxyacetophenone	2620-3-X7	5G	$280
1-(2-Fluoro-6-hydroxyphenyl)ethanone	J51216	10g	$380
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2'-FLUORO-6'-HYDROXYACETOPHENONE Properties

Boiling point	224.0±20.0 °C(Predicted)
Density	1.25g/ml
refractive index	1.534
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	liquid
pka	9.17±0.10(Predicted)
color	Clear, faint lime

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Hazard Note

Irritant

HS Code

2914500090

NFPA 704

	1
2		0

2'-FLUORO-6'-HYDROXYACETOPHENONE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F598130	1-(2-Fluoro-6-hydroxyphenyl)ethanone	93339-98-1	10mg	$45	2021-12-16	Buy
SynQuest Laboratories	2620-3-X7	2'-Fluoro-6'-hydroxyacetophenone	93339-98-1	1g	$93	2021-12-16	Buy
Apolloscientific	PC9896	2'-Fluoro-6'-hydroxyacetophenone	93339-98-1	5g	$254	2021-12-16	Buy
SynQuest Laboratories	2620-3-X7	2'-Fluoro-6'-hydroxyacetophenone	93339-98-1	5G	$280	2021-12-16	Buy
AK Scientific	J51216	1-(2-Fluoro-6-hydroxyphenyl)ethanone	93339-98-1	10g	$380	2021-12-16	Buy

Product number	Packaging	Price	Buy
F598130	10mg	$45	Buy
2620-3-X7	1g	$93	Buy
PC9896	5g	$254	Buy
2620-3-X7	5G	$280	Buy
J51216	10g	$380	Buy

2'-FLUORO-6'-HYDROXYACETOPHENONE Chemical Properties,Uses,Production

Preparation

Preparation by reaction of boron tribromide on 2-fluoro-6- methoxyacetophenone (I) in methylene chloride at ?65° to ?80° (56%). The precursor (I) was obtained by reaction of methyl magnesium iodide on 2-fluoro-6-methoxybenzonitrile in refluxing toluene (quantitative yield).

Synthesis

120484-50-6

93339-98-1

General procedure for the synthesis of 2-fluoro-6-hydroxyacetophenone from 2-fluoro-6-methoxyacetophenone: aluminum chloride (14.3 g, 0.107 mol) was added to an ice-cold solution of intermediate 3 (9.0 g, 53.5 mmol) in dichloromethane (70 mL), followed by slow warming of the reaction mixture to room temperature. After the reaction was carried out for 12 h, the reaction was quenched with aqueous 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-hydroxyacetophenone as a brown liquid (5.48 g, 66% yield). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 400 MHz): δ 12.72 (s, 1H, OH), 7.40 (m, 1H, Ar-H), 6.78 (d, J = 8.5 Hz, 1H, Ar-H), 6.62 (dd, J = 11.3, 8.3 Hz, 1H, Ar-H), 2.69 (d, J = 7.2 Hz, 3H, CH3).

References

[1] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 101
[2] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[3] Patent: US5399584, 1995, A
[4] Patent: US2007/14733, 2007, A1. Location in patent: Sheet 14
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 619 - 622

2'-FLUORO-6'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

2'-FLUORO-6'-METHOXYACETOPHENONE Hydrochloric acid Water Aluminum chloride Dichloromethane

Preparation Products

2'-FLUORO-6'-HYDROXYACETOPHENONE Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14359	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58
Aston Chemical	13000000000	sales@astonchem.com	United States	1634	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Win-Win chemical CO., Limited	58
Alfa Chemistry	58
Aston Chemical	58
Hefei Hirisun Pharmatech Co., Ltd	58
CD Chemical Group Limited	58

View Lastest Price from 2'-FLUORO-6'-HYDROXYACETOPHENONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-12	2'-FLUORO-6'-HYDROXYACETOPHENONE 93339-98-1	US $1.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

2'-FLUORO-6'-HYDROXYACETOPHENONE
93339-98-1
US $1.00 / KG
99%
Career Henan Chemical Co

2'-FLUORO-6'-HYDROXYACETOPHENONE Spectrum

2'-FLUORO-6'-HYDROXYACETOPHENONE(93339-98-1)¹HNMR 2'-FLUORO-6'-HYDROXYACETOPHENONE(93339-98-1)¹⁹FNMR

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1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one 1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE 2-FLUORO-6-HYDROXYACETOPHENONE 1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol Ethanone, 1-(2-fluoro-6-hydroxyphenyl)- 2'-Fluoro-6'-hydroxyacetophenone 93339-98-1 9339-98-1 Aromatic Acetophenones & Derivatives (substituted)