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Z-D-MET-OH

Z-D-MET-OH Structure
Z-D-MET-OH structure
CAS No.
28862-80-8
Chemical Name:
Z-D-MET-OH
Synonyms
Z-D-MET;Z-D-MET-OH;CBZ-D-MET-OH;N-Cbz-D-Met-OH;Z-D-METHIONINE;Cbz-D-Methinine;CBZ-D-METHIONINE;N-CBZ-D-METHIONINE;Z-D-MET-OH USP/EP/BP;Z-D-METHIONINE extrapure
CBNumber:
CB7757394
Molecular Formula:
C13H17NO4S
Molecular Weight:
283.34
MDL Number:
MFCD00026043
MOL File:
28862-80-8.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:47
Product description Number Pack Size Price
CARBOBENZYLOXY-D-METHIONINE AldrichCPR S777129 50MG $30.7
N-Carbobenzoxy-D-methionine >98.0%(T) C0665 5g $39
N-Carbobenzoxy-D-methionine >98.0%(T) C0665 25g $117
N-Carbobenzoxy-D-methionine >98.0%(T) C0665 100mg $16
Z-D-methionine 283778 5g $360
More product size
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Z-D-MET-OH Properties

Melting point 67-69°C
Density 1.253
refractive index 26 ° (C=1, MeOH)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Safety Statements  24/25
HS Code  29225090
NFPA 704
1
0 0

Z-D-MET-OH price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S777129 CARBOBENZYLOXY-D-METHIONINE AldrichCPR 28862-80-8 50MG $30.7 2025-07-31 Buy
TCI Chemical C0665 N-Carbobenzoxy-D-methionine >98.0%(T) 28862-80-8 5g $39 2025-07-31 Buy
TCI Chemical C0665 N-Carbobenzoxy-D-methionine >98.0%(T) 28862-80-8 25g $117 2025-07-31 Buy
TCI Chemical C0665 N-Carbobenzoxy-D-methionine >98.0%(T) 28862-80-8 100mg $16 2025-07-31 Buy
Usbiological 283778 Z-D-methionine 28862-80-8 5g $360 2021-12-16 Buy
Product number Packaging Price Buy
S777129 50MG $30.7 Buy
C0665 5g $39 Buy
C0665 25g $117 Buy
C0665 100mg $16 Buy
283778 5g $360 Buy

Z-D-MET-OH Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).

Synthesis

D-Methionine

348-67-4

Benzyl chloroformate

501-53-1

N-Cbz-L-methionine

1152-62-1

General procedure for the synthesis of Z-L-methionine from D-methionine and benzyl chloroformate: (2R)-2-Amino-4-(methylthioalkyl)butyric acid (4.90 g, 32.84 mmol) and sodium carbonate (16.91 g, 159.54 mmol) were dissolved in water (100 mL) at room temperature. Subsequently, a solution of benzyl chloroformate (5.59 g, 32.74 mmol) in dioxane (50 mL) was added slowly and dropwise over 10 minutes. The resulting reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (100 mL). The reaction mixture was extracted with ethyl acetate (300 mL x 3) and the organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by chromatography on a C18 reversed-phase column using gradient elution with aqueous acetonitrile (0 to 50% acetonitrile, 30 min) to afford (2R)-2-[[(benzyloxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid as a yellow oil (3.48 g, 36% yield).

References

[1] Journal of Agricultural and Food Chemistry, 1995, vol. 43, # 10, p. 2728 - 2734
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 937 - 960
[3] Patent: WO2017/106607, 2017, A1. Location in patent: Paragraph 00400

Z-D-MET-OH Preparation Products And Raw materials

Raw materials

D-Methionine Benzyl chloroformate Sodium carbonate Water 1,4-Dioxane

Preparation Products

Z-D-MET-OH Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd 		+8617390183901 cynthia@enlaibio.com China 1100 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
GL Biochem(Binhai) Ltd. 		+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20284 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Supplier Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
GL Biochem(Binhai) Ltd. 		58
Dideu Industries Group Limited 		58
Finetech Industry Limited 		58

View Lastest Price from Z-D-MET-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cbz-D-Met-OH pictures 2025-11-17 Cbz-D-Met-OH
28862-80-8
 US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Z-D-MET-OH pictures 2019-07-06 Z-D-MET-OH
28862-80-8
 US $1.00 / KG 1KG 99% 20kg Career Henan Chemical Co
  • Cbz-D-Met-OH pictures
  • Cbz-D-Met-OH
    28862-80-8
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
  • Z-D-MET-OH pictures
  • Z-D-MET-OH
    28862-80-8
  • US $1.00 / KG
  • 99%
  • Career Henan Chemical Co

Z-D-MET-OH Spectrum

Z-D-MET-OH(28862-80-8)1HNMRZ-D-MET-OH(28862-80-8)IR1

28862-80-8(Z-D-MET-OH)Related Search:

Z-D-GLU-OH Z-D-ARG-OH Z-D-TYR(TBU)-OME Z-D-TYR-OH Z-D-THR-OH
Z-D-HIS-OH Z-D-GLN-OH Z-D-PHG-OH Z-D-Met-Onp Z-D-NLE-OH
Z-D-NLE-ONP Z-D-MEALA-OH Z-D-NVA-OH Z-D-LYS-OH Z-D-THR(TBU)-OH DCHA
Z-L-MET-OH,Z-MET-OH,N-Benzyloxycarbonyl-L-methionine~Z-Met-OH N-(Benzo[b]thiophenesulphone-2-methoxycarbonyl)-L-methionine~Bsmoc-Met-OH,Bsmoc-Met-OH Boc-Met-OH.CHA

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N-CBZ-D-METHIONINE N-CARBOBENZOXY-D-METHIONINE N-ALPHA-CBZ-D-METHIONINE N-ALPHA-CARBOBENZOXY-D-METHIONINE N-ALPHA-BENZYLOXYCARBONYL-D-METHIONINE Z-D-MET-OH Z-D-METHIONINE Z-D-METHIONINE extrapure (R)-2-(Benzyloxycarbonylamino)-4-methylthiobutyric acid N-Cbz-D-Met-OH CBZ-D-MET-OH CBZ-D-METHIONINE Z-D-MET Cbz-D-Methinine (R)-2-(benzyloxycarbonylamino)-4-(methylthio)butanoic acid D-(Carbobenzyloxy)methionine N-Carbobenzyloxy-D-methionine N-Cbz-D-methionine Z-D-Met-OH Z-D-methionine≥ 99% (HPLC) (2R)-2-{[(benzyloxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid N-Carbobenzoxy-D-methionine > D-Methionine, N-[(phenylmethoxy)carbonyl]- Z-D-MET-OH USP/EP/BP (2R)-4-methylsulfanyl-2-(phenylmethoxycarbonylamino)butanoic acid N-Cbz-D-methionine, 98% [Z-D-MetOH] CARBOBENZYLOXY-D-METHIONINE N-α-Benzyloxycarbonyl-D-methionine 28862-80-8 CARBOXYLIC ACID Amino Acids (N-Protected) Cbz-Amino Acids Protected & Labeled Amino Acids Amino Acids Amino Acids (N-Protected) Biochemistry Cbz-Amino Acids