5-Aminophthalide
- CAS No.
- 65399-05-5
- Chemical Name:
- 5-Aminophthalide
- Synonyms
- Roxadustat-002;Einecs 265-731-1;5-Aminophthliade;5-AMINOPHTHALIDE;Aminophthalide,5-;TIMTEC-BB SBB007358;5-Aminophthalide ,98%;Roxadustat Impurity 91;5-AMINOPHENYL PHTHALEIN;5-amino-3H-2-benzofuran-1-one
- CBNumber:
- CB7763102
- Molecular Formula:
- C8H7NO2
- Molecular Weight:
- 149.15
- MDL Number:
- MFCD00778315
- MOL File:
- 65399-05-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Aminophthalide | A577133 | 500mg | $90 |
| 5-Aminophthalide | FA70724 | 1g | $100 |
| 5-Aminophthalide | FA70724 | 2g | $140 |
| 5-Aminophthalide 95% | OR927089 | 250mg | $175 |
| 5-Aminophthalide | FA70724 | 500mg | $65 |
| More product size | |||
| Melting point | 178 °C |
|---|---|
| Boiling point | 438.6±45.0 °C(Predicted) |
| Density | 1.376±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Solid |
| pka | 2.10±0.20(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C8H7NO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3H,4,9H2 |
| InChIKey | ISMUWQMUWFPFBZ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(N)C=C2)CO1 |
| CAS DataBase Reference | 65399-05-5(CAS DataBase Reference) |
| FDA UNII | 3TMN4XTM2N |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-52 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2932990090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 3 |
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| NFPA 704 |
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5-Aminophthalide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A577133 | 5-Aminophthalide | 65399-05-5 | 500mg | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA70724 | 5-Aminophthalide | 65399-05-5 | 1g | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA70724 | 5-Aminophthalide | 65399-05-5 | 2g | $140 | 2021-12-16 | Buy |
| Apolloscientific | OR927089 | 5-Aminophthalide 95% | 65399-05-5 | 250mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA70724 | 5-Aminophthalide | 65399-05-5 | 500mg | $65 | 2021-12-16 | Buy |
5-Aminophthalide Chemical Properties,Uses,Production
Synthesis
3676-85-5
65399-05-5
The general steps for the synthesis of 5-aminophthalide from 4-amino phthalimide are as follows: first, phthalimide (7) undergoes a bromoacetal reaction to produce compound 6, as shown in Figure 1. According to the literature, these transformations have been carried out on a large scale and some of the steps have been optimized. The specific operation included the nitration of 200 g of phthalimide (7) to obtain 146 g of 5-nitrophthalimide (8). Subsequently, a 2L Parr hydrogenator pressure vessel was used to reduce 30 g of 8 by catalytic hydrogenation to 25 g of amine 9. This step was the bottleneck of the synthesis due to the large amount of solvent required. Next, aminophthalide 10 was quantitatively obtained from 9 by a copper-catalyzed reaction of zinc in an aqueous base.Steps b and c can be combined, i.e., treatment of 8 with zinc powder and copper(II) sulfate in a 2 M NaOH aqueous solution.This modification is not demonstrated in Fig. 1. The one-step preparation of 100 g of 10 from 146 g of 9 may be achieved by eliminating the bottleneck step, as shown in FIG. 11. The steps detailed in FIG. 11 include: a) reaction using HNO3 and H2SO4 at 0 °C in 56% yield; b) 5% Pd/C catalyzed hydrogenation in EtOAc in 97% yield; c) reaction with Zn and CuSO4 in 6 M NaOH at 5 °C. followed by heating at 70-80°C for 16 h in 100% yield; d) treatment with NaNO2 and 4 M HBr at 0°C, followed by the addition of CuBr; e) reaction with DIBAL in toluene at -42°C; f) treatment with BF3-OEt2 and MeOH at room temperature.
References
[1] Tetrahedron, 1998, vol. 54, # 26, p. 7485 - 7496
[2] Patent: US2011/77394, 2011, A1. Location in patent: Page/Page column 15
[3] Archiv der Pharmazie, 1985, vol. 318, # 7, p. 640 - 648
[4] Patent: CN108383833, 2018, A. Location in patent: Paragraph 0012
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 53 - 56
5-Aminophthalide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9546 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15079 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
View Lastest Price from 5-Aminophthalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-Aminophthalide
65399-05-5
|
US $7.00 / KG | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- 5-Aminophthalide
65399-05-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
