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Cefmenoxime

Cefmenoxime structure

CAS No.: 65085-01-0

Chemical Name:: Cefmenoxime

Synonyms: CMX;SCE 1365;AB 50912;CEFMENOXIME;Cefotaxime Isomer;Cefmenoxime USP/EP/BP;7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid;(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;[6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid

CBNumber:: CB7771510

Molecular Formula:: C16H17N9O5S3

Molecular Weight:: 511.56

MDL Number:: MFCD00864851

MOL File:: 65085-01-0.mol

MSDS File:: SDS

Last updated:2023-11-30 13:04:11

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Cefmenoxime Properties

Density	1.96±0.1 g/cm3(Predicted)
pka	2.61±0.50(Predicted)
CAS DataBase Reference	65085-01-0(CAS DataBase Reference)
FDA UNII	KBZ4844CXN
ATC code	J01DD05

Cefmenoxime price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C242838	Cefmenoxime	65085-01-0	10mg	$580	2021-12-16	Buy
TRC	C242838	Cefmenoxime	65085-01-0	25mg	$1155	2021-12-16	Buy
American Custom Chemicals Corporation	API0007249	CEFMENOXIME 95.00%	65085-01-0	5G	$909.56	2021-12-16	Buy
AHH	MT-49073	Cefmenoxime 98%	65085-01-0	0.1g	$910	2021-12-16	Buy
AvaChem	2848	Cefmenoxime	65085-01-0	25mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
C242838	10mg	$580	Buy
C242838	25mg	$1155	Buy
API0007249	5G	$909.56	Buy
MT-49073	0.1g	$910	Buy
2848	25mg	$55	Buy

Cefmenoxime Chemical Properties,Uses,Production

Originator

Tacef,Takeda,W. Germany,1983

Uses

Antibacterial.

Uses

Cefmenoxime (cas# 65085-01-0) is a compound useful in organic synthesis.

Definition

ChEBI: A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.

Manufacturing Process

7β-[α-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido]cephalosporanicacid trifluoroacetic acid salt is dissolved in a solution of 272 mg of 1-methyl-5- mercapto-1H-tetrazole, 555 mg of sodium bicarbonate and 68 mg of triethylbenzylammonium bromide in 10 ml of water. The solution is heated at 60°C in nitrogen atmosphere for 6 hours. After cooling, the reaction solution is passed through a column of Amberlite XAD-2 and eluted with water and then with 2.5% ethanol. The procedure yields sodium 7β-[α-methoxyimino-α- (2-aminothiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3- cephem-4-carboxylate, MP 174°C to 175°C (decomposition).

brand name

Cefmax (TAP).

Therapeutic Function

Antibacterial

Antimicrobial activity

A semisynthetic cephalosporin supplied as the hydrochloride. Its activity is very similar to that of cefotaxime. A 500 mg intramuscular injection achieves a plasma concentration of 15 mg/L after 40 min. A concentration of 200 mg/L is attained after intravenous administration of 1 g. The plasma half-life is c. 1 h. Around 77% is protein bound. Probenecid increases peak plasma levels and extends the plasma half-life to 1.8 h. Therapeutic concentrations are achieved in CSF. There is a degradation product with a long half-life (around 40 h), but 80–92% of the drug is recovered unchanged from the urine. In patients with renal insufficiency, no significant relation was found between creatinine clearance and peak serum concentrations but there was a linear relationship with plasma half-life and total body clearance. About 10% of the dose appears in the feces, mostly extensively degraded, possibly by the fecal flora.
Toxicity, side effects and clinical use are those common to group 4 cephalosporins.

Cefmenoxime Preparation Products And Raw materials

Raw materials

Three B Lithium tert-butoxide Acetate Ammonium bromide 1H-TETRAZOLE

Nitrogen Cefotaxime sodium Trifluoroacetic acid Bromobenzene Cefotaxime

N,N-Dimethylacetamide 5-Mercapto-1-methyltetrazole

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Preparation Products

Cefmenoxime Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	878	58
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Runbin Biotechnology Co. LTD	13180553332	2179877681@qq.com	CHINA	996	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hebei Henghe Import and Export Trading Co. LTD	+8618032935937 18032916000	demi@hbtycoon.com	CHINA	449	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Lingding Biotechnology Co., Ltd.	58
Shanghai Yingrui Biopharma Co., Ltd.	60
Hebei Guanlang Biotechnology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hebei Runbin Biotechnology Co. LTD	58
TargetMol Chemicals Inc.	58
Hebei Henghe Import and Export Trading Co. LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Cefmenoxime manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-31	Cefmenoxime 65085-01-0	US $30.00-20.00 / kg	1kg	99%	2000000	Shanghai Chinqesen Biotechnology Co., Ltd.
2023-11-30	Cefmenoxime 65085-01-0	US $240.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.
2023-06-20	Cefmenoxime 65085-01-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Cefmenoxime
65085-01-0
US $30.00-20.00 / kg
99%
Shanghai Chinqesen Biotechnology Co., Ltd.

Cefmenoxime
65085-01-0
US $240.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

Cefmenoxime
65085-01-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

65085-01-0(Cefmenoxime)Related Search:

7-(5-amino-5-carboxyvaleramido)cephalosporanic acid 2-Methyl-4-isothiazolin-3-one Cephalexin PENICILLINASE Ceftizoxime sodium

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2-Mercapto-5-methyl-1,3,4-thiadiazole 2-(2-Aminothiazol-4-yl)glyoxylic acid Cefotaxime sodium 2,2'-Dithiobis(benzothiazole)

Cefotaxime Benzothiazole Ceftizoxime Fosthiazate 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

2Cefmenoxime·Hydrochloride,CEFMENOXIME HCL,CEFMENOXIME HYDROCHLORIDE 7-TMCA Cefetamet hydrochloride

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CEFMENOXIME (6r-(6alpha,7beta(z)))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid (6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid CMX (6R,7R)-7-[(2E)-2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-{[(1-Methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]]- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- AB 50912 SCE 1365 [6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid Cefotaxime Isomer (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)- Cefmenoxime USP/EP/BP 65085-01-0 C16H17N9O5S3 Pharmaceutical intermediate