CROMAKALIM
- CAS No.
- 94470-67-4
- Chemical Name:
- CROMAKALIM
- Synonyms
- BRL-34915;CROMAKALIM;AKOS 91890;(±)-Cromakalim;(+/-)-CROMAKALIM;Cromakalim, KIR6.x (KATP) channel activator;Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2-;rac-(3α*,4β*)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)chroman-6-carbonitrile;(-trans-6-Cyano-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-benzo[b]pyran-3-ol;(3S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile
- CBNumber:
- CB7771686
- Molecular Formula:
- C16H18N2O3
- Molecular Weight:
- 286.33
- MDL Number:
- MFCD00133201
- MOL File:
- 94470-67-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 242-244°C |
|---|---|
| Boiling point | 482.340±45.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.313±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | solid |
| pka | 13.175±0.60(predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | 1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1 |
| InChIKey | TVZCRIROJQEVOT-CABCVRRESA-N |
| SMILES | CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N |
| FDA UNII | 0G4X367WA3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CROMAKALIM price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1055 | Cromakalim | 94470-67-4 | 10mg | $234 | 2026-04-30 | Buy |
| Sigma-Aldrich | C1055 | Cromakalim | 94470-67-4 | 50mg | $1040 | 2026-04-30 | Buy |
| Cayman Chemical | 14601 | (±)-Cromakalim ≥98% | 94470-67-4 | 10mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 14601 | (±)-Cromakalim ≥98% | 94470-67-4 | 50mg | $530 | 2026-04-30 | Buy |
| TRC | TRC-C795000-50MG | (+/-)-Cromakalim | 94470-67-4 | 50mg | $418 | 2026-06-03 | Buy |
CROMAKALIM Chemical Properties, Uses, Production
Description
(±)-
Chemical Properties
White Crystalline Solid
Uses
Cromakalim has been used:
- as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
- as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
- as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.
Uses
Cromakalim causes vasodilation by activation of potassim channels
Definition
ChEBI: Cromakalim is a 1-benzopyran.
Biological Activity
Prototypical K ATP channel opener. Relaxes rabbit isolated portal vein with an IC 50 value of 21 nM . Potent, orally active and hypotensive in vivo .
Biochem/physiol Actions
Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
References
[1] M C SANGUINETTI. BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 21: 8360-8364. DOI:10.1073/pnas.85.21.8360
[2] XUE-FENG WU . Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord[J]. PAIN®, 2011, 152 11: Pages 2605-2615. DOI:10.1016/j.pain.2011.08.003
[3] PHILIPPE TRECHOT Fanny T Jean Baptiste Conart. ATP sensitive potassium channel openers: A new class of ocular hypotensive agents[J]. Experimental eye research, 2019, 178: Pages 223-224. DOI:10.1016/j.exer.2016.06.014
[4] ZHIJUAN CAO. Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord[J]. Clinical Journal of Pain, 2016, 32 1: 617-623. DOI:10.1097/ajp.0000000000000299
CROMAKALIM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
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