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Haloperidol

Haloperidol
Haloperidol structure
CAS No.
52-86-8
Chemical Name:
Haloperidol
Synonyms
ALDO;r1625;Dozic;Halol;Sernas;Sernel;Haldol;Linton;Pernox;R 1625
CBNumber:
CB7774829
Molecular Formula:
C21H23ClFNO2
Formula Weight:
375.86
MOL File:
52-86-8.mol

Haloperidol Properties

Melting point:
152 °C
Boiling point:
529.0±50.0 °C(Predicted)
Density 
1.1820 (estimate)
Flash point:
9℃
storage temp. 
Store at RT
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL
pka
8.3(at 25℃)
form 
powder
color 
white
Water Solubility 
2.058mg/L(22.5 ºC)
Merck 
14,4598
CAS DataBase Reference
52-86-8(CAS DataBase Reference)
FDA UNII
J6292F8L3D
NCI Dictionary of Cancer Terms
Haldol; haloperidol
NIST Chemistry Reference
Haloperidol(52-86-8)
Proposition 65 List
Haloperidol
EPA Substance Registry System
Haloperidol (52-86-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS08,GHS06,GHS07
Signal word  Danger
Hazard statements  H360-H225-H301+H311+H331-H370-H301-H315-H317-H319-H335-H361
Precautionary statements  P260-P280-P301+P310-P311-P305+P351+P338-P201-P301+P310+P330-P308+P313-P333+P313-P261-P301+P310a-P501a-P264-P270-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P210
Hazard Codes  T,F
Risk Statements  60-61-25-36/37/38-43-39/23/24/25-23/24/25-11
Safety Statements  53-26-36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  EU1575000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Toxicity LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)

Haloperidol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H-030 Haloperidol solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 52-86-8 030-1ml $26.9 2019-12-02 Buy
Sigma-Aldrich 1303002 Haloperidol United States Pharmacopeia (USP) Reference Standard 52-86-8 200mg $352.8 2019-12-02 Buy
TCI Chemical H0912 Haloperidol >98.0%(HPLC)(T) 52-86-8 5g $73 2020-06-24 Buy
TCI Chemical H0912 Haloperidol >98.0%(HPLC)(T) 52-86-8 25g $216 2020-06-24 Buy
Alfa Aesar J61688 Haloperidol 52-86-8 5g $75.8 2020-06-24 Buy

Haloperidol Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Uses

Antidyskinetic; antipsychotic

Definition

ChEBI: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

brand name

Haldol (OrthoMcNeil).

General Description

Haloperidol, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4-fluorobutyrophenone (Haldol), is anodorless white to yellow crystalline powder. Haloperidol iswell and rapidly absorbed and has a high bioavailability. It ismore than 90% bound to plasma proteins. Haloperidol is excretedslowly in the urine and feces. About 30% of a dose isexcreted in urine and about 20% of a dose in feces via biliaryelimination,and only 1% of a dose is excreted as unchangeddrug in the urine.Haloperidol is a minor substrate of CYP1A2 and a major substrate of CYP2D6 and CYP3A4.CYP2D6 inhibitors may increase the levels/effects ofhaloperidol.Haloperidol may increase the levels/effects ofCYP2D6 substrates and it may decrease the bioactivationof CYP2D6 prodrugs substrates. Haloperidol also is a moderateinhibitor of CYP2D6 and CYP3A4. CYP3A4 inducersmay decrease the levels/effects of haloperidol, whereasCYP3A4 inhibitors may increase the levels/effects ofhaloperidol. Centrally acting acetylcholinesterase inhibitorsmay increase the risk of antipsychotic-related EPS. The precisemechanism of antipsychotic action is unclear but isconsidered to be associated with the potent DA D2receptor–blocking activity in the mesolimbic system and theresulting adaptive changes in the brain. Haloperidol is usedprimarily for the long-term treatment of psychosis and is especiallyuseful in patients who are noncompliant with theirdrug treatment.

General Description

Haloperidol, 4[4-(p-chlorophenyl)-4-hydroxypiperidone]-4' -n-fluorobutyrophenone (Haldol),the representative of several related classes of aromaticbutylpiperidine derivatives, is a potent antipsychotic usefulin schizophrenia and in psychoses associated with braindamage. It is frequently chosen as the agent to terminatemania and often used in therapy for Gilles de la Tourettesyndrome. Haloperidol-induced dyskinesias may involveneurotoxicological metabolite similar to dopaminergic toxicantMPP+.

Pharmaceutical Applications

Haloperidol is an analogue of the dopamine D2 receptor antagonist and is an older antipsychotic drug. The drug is used in the treatment of schizophrenia, a neuropsychiatric disorder. In general, antipsychotic drugs work by blocking the dopamine D2 receptors.
Haloperidol is such an antipsychotic drug, which was developed in the 1950s and entered the clinic soon after that. Its use is limited by the high incidence of extrapyramidal symptoms (movement disorders caused by drugs affecting the extrapyramidal system, a neural network which is part of the motor system). Nevertheless, haloperidol may be used for the rapid control of hyperactive psychotic states and is popular for treating restlessness in the elderly.

Biological Activity

Dopamine antagonist with selectivity for D 2 -like receptors (K i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Subtype-selective NMDA antagonist.

Haloperidol Preparation Products And Raw materials

Raw materials

Preparation Products


Haloperidol Suppliers

Global( 166)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29643 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58

View Lastest Price from Haloperidol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-10 Haloperidol
52-86-8
US $1.00 / KG 1KG 98%-99.9% 100kg Career Henan Chemical Co

Haloperidol Spectrum


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