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Mannose Triflate

Mannose Triflate structure

CAS No.: 92051-23-5

Chemical Name:: Mannose Triflate

Synonyms: MANNOSE TRIFLATE;TATM;TATM USP/EP/BP;MANNOSE TRIFLATE F;beta-D-Mannopyranose;Mannose Triflate?New;Mannose triflate≥ 99%(GC);1,3,4,6-Tetra-O-acetyl-2-O-;Mannose Triflate, ultra pure;Mannose Triflate, CAS 92051-23-5

CBNumber:: CB7774955

Molecular Formula:: C15H19F3O12S

Molecular Weight:: 480.36

MDL Number:: MFCD00012353

MOL File:: 92051-23-5.mol

MSDS File:: SDS

Last updated:2025-10-23 17:25:30

Product description	Number	Pack Size	Price
Mannose triflate For PET imaging, ≥98% (TLC)	M1568	20mg	$28.5
Tetra-O-acetyl-mannose triflate European Pharmacopoeia (EP) Reference Standard	Y0001087	2each	$153
β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate 98%	655112	100mg	$36.6
Tetra-O-acetyl-mannose triflate European Pharmacopoeia (EP) Reference Standard	Y0001087	2EA	$144
1,3,4,6-Tetra-O-acetyl-2-O-(trifluoromethanesulfonyl)-beta-D-mannopyranose >98.0%(GC)	T2307	100mg	$39
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Mannose Triflate Properties

Melting point	118-122 °C
alpha	[α]D20 -14～-17゜(c=1,CHCl3)
Boiling point	481.6±45.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
refractive index	-16 ° (C=1, CHCl3)
storage temp.	-20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	White to Off-White
optical activity	[α]22/D -16°, c = 1 in chloroform
BRN	4341413
InChI	InChI=1/C15H19F3O12S/c1-6(19)25-5-10-11(26-7(2)20)12(27-8(3)21)13(14(29-10)28-9(4)22)30-31(23,24)15(16,17)18/h10-14H,5H2,1-4H3/t10-,11-,12+,13+,14-/s3
InChIKey	OIBDVHSTOUGZTJ-UBBZJQTNNA-N
SMILES	[C@H]1(OC(=O)C)[C@H](OC(=O)C)[C@H](O[C@@H](OC(=O)C)[C@H]1OS(=O)(=O)C(F)(F)F)COC(=O)C \|&1:0,5,10,12,17,r\|
FDA UNII	0KI8FFQ6TT
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H319
Precautionary statements	P261-P280-P271
Hazard Codes	Xi
Safety Statements	24/25
WGK Germany	3
F	10-21
HS Code	29329990

Mannose Triflate price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M1568	Mannose triflate For PET imaging, ≥98% (TLC)	92051-23-5	20mg	$28.5	2025-07-31	Buy
Sigma-Aldrich	Y0001087	Tetra-O-acetyl-mannose triflate European Pharmacopoeia (EP) Reference Standard	92051-23-5	2each	$153	2025-07-31	Buy
Sigma-Aldrich	655112	β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate 98%	92051-23-5	100mg	$36.6	2025-07-31	Buy
Sigma-Aldrich	Y0001087	Tetra-O-acetyl-mannose triflate European Pharmacopoeia (EP) Reference Standard	92051-23-5	2EA	$144	2023-06-20	Buy
TCI Chemical	T2307	1,3,4,6-Tetra-O-acetyl-2-O-(trifluoromethanesulfonyl)-beta-D-mannopyranose >98.0%(GC)	92051-23-5	100mg	$39	2025-07-31	Buy

Product number	Packaging	Price	Buy
M1568	20mg	$28.5	Buy
Y0001087	2each	$153	Buy
655112	100mg	$36.6	Buy
Y0001087	2EA	$144	Buy
T2307	100mg	$39	Buy

Mannose Triflate Chemical Properties,Uses,Production

Description

Mannose triflate is a glucose analog. Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. 18F-FDG is an imaging technique for cancer.

Physical properties

White to off-white powder or crystal

Chemical Properties

Colourless or nearly colourless crystals, mp 119 - 122℃; soluble in acetonitrile, DMSO, methanol, acetone, insoluble in aqueous media

Uses

1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose is a radiolabelled pharmaceutical preparation for diagnostic aims used in positron emission tomography.

Preparation

The tetraacetyl mannose (1.8 g, 5 mmol) was dissolved in anhydrous CH2Cl2(14 mL) containing dry pyridine (0.9 mL, 11 mmol). This solution was cooled to -15°C, and trifluoromethanesulfonic anhydride (triflic anhydride) (0.9 mL, 5.2 mmol) was added dropwise over 25 min under a nitrogen atmosphere with vigorous stirring. The mixture was then allowed to reach room temperature overnight. The reaction mixture was successively washed with ice-cold saturated aqueous NaHCO3(50 mL) and water (50 mL). The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator.2-Tf-O-AcManwas isolated by column chromatography on silica with hexane :EtOAc=1: 1 as the eluant as white solid Mannose triflate(1.4 g, 56percent).

Synthesis

358-23-6

1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose

18968-05-3

92051-23-5

General procedure for the synthesis of mannose trifluorosulfonate from trifluoromethanesulfonic anhydride and (2S,3S,4R,5R,6R)-6-(acetyloxymethyl)-3-hydroxytetrahydro-2H-pyran-2,4,5-triyltriacetate: tetraacetylmannose (5, 1.8 g, 5 mmol) was dissolved in anhydrous pyridine (0.9 mL, 11 mmol) containing anhydrous dichloromethane (14 mL). The solution was cooled to -15°C and trifluoromethanesulfonic anhydride (0.9 mL, 5.2 mmol) was added slowly and dropwise over 25 min under vigorous stirring and nitrogen protection. Subsequently, the reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction mixture was washed sequentially with ice-cold saturated aqueous sodium bicarbonate solution (50 mL) and deionized water (50 mL). The organic layer was dried with anhydrous sodium sulfate, filtered, and concentrated on a rotary evaporator. The product was purified by silica gel column chromatography using hexane:ethyl acetate (1:1, v/v) as eluent to afford mannose trifluorosulfonate (1.4 g, 56% yield) in white solid form. Thin layer chromatography (TLC) showed an Rf value of 0.5 (unfolding agent: hexane: ethyl acetate = 1:1).

References

[1] Tetrahedron, 1992, vol. 48, # 47, p. 10249 - 10264
[2] Journal of the American Chemical Society, 2010, vol. 132, # 21, p. 7405 - 7417
[3] Carbohydrate Research, 1991, vol. 210, p. 333 - 337
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 3, p. 564 - 575
[5] Carbohydrate Research, 1984, vol. 128, p. 291 - 296

Mannose Triflate Preparation Products And Raw materials

Raw materials

Trifluoromethanesulfonic anhydride 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose Pyridine Dichloromethane

Preparation Products

Mannose Triflate Suppliers

Global( 252)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Qingdao Yonghefeng Economic and Trade Co., Ltd.	+86-13375559818	cfy69@163.com	China	195	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10997	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20171	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13505	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21615	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Qingdao Yonghefeng Economic and Trade Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from Mannose Triflate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-13	Mannose Triflate 92051-23-5	US $0.00 / G	1G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-09-25	TATM 92051-23-5	US $6.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-08-20	Mannose Triflate 92051-23-5	US $0.00-0.00 / kg	1kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd

Mannose Triflate
92051-23-5
US $0.00 / G
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

TATM
92051-23-5
US $6.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

Mannose Triflate
92051-23-5
US $0.00-0.00 / kg
99.99%
Chongqing Soarwin Technology Co., Ltd

Mannose Triflate Spectrum

TATM(92051-23-5)IR

92051-23-5(Mannose Triflate)Related Search:

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1,6-Diacetoxyhexane L(+)-Rhamnose monohydrate 1,1,3-TRIMETHOXYBUTANE ISOPROPYL METHANESULFONATE TATM

Trifluoromethane FLUOROSULFONIC ACID D-Mannose

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MANNOSE TRIFLATE F 1,3,4,6-Tetraacetate 2-(trifluoromethanesulfonate) -D-Mannopyranose tetraacetyltrifluoromethanesulfonyl-beta-D-mannopyranose Mannose triflate, TATM, 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose 1-O,3-O,4-O,6-O-Tetraacetyl-2-O-(trifluoromethylsulfonyl)-β-D-mannopyranose 1-O,3-O,4-O,6-O-Tetraacetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate Mannose triflate 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethylsulfonyl-β-D-mannopyranose β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate,1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose, Mannose triflate, TATM β-D-Maopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate 1,3,4,6-Tetraacetate 2-(trifluoroMethanesulfonate) 1,3,4,6-Tetra-O-acetyl-2-O-trifluoroMethane 1,3,4,6-Tetra-O-acetyl-2-O-[(trifluoromethyl)sulphonyl]-beta-D-mannopyranose TATM, 1,3,4,6-Tetra-O-acetyl-2-O-triflyl-beta-D-mannopyranose b-D-Mannopyranose,1,3,4,6-tetraacetate 2-(trifluoroMethanesulfonate) beta-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoroMethanesulfonate 98% beta-D-Mannopyranose 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl- β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate(TATM) BETA-D-MANNOPYRANOSE 1,3,4,6-TETRAACETATE 2-TRIFLATE BETA-D-MANNOPYRANOSE, 1,3,4,6-TETRAACETATE 2-(TRIFLUOROMETHANE-SULFONATE) BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETATE 2-O-TRIFLUOROMETHANESULFONATE 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUORO-METHANESULFONYL-BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHANSULFONYL-BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULPHONYL-B-D-MANNOPYRANOSE TATM β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyranose tetra-O-acetyl-2-O-trifluoromethane-sulfonyl-beta 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUORO-*METHANESULFONY 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-b-D-mannopyranose 1,3,4,6-Tetra-O-acetyl-2-O- 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE, TATM 1,3,4,6-TETRA-O-ACETYL-2-O-TRIFLUOROMETHYLSULFONYL-B-D-MANNOPYRANOSE(MANNOSE TRIFLATE) TETRA-O-ACETYL-2-O-TRIFLUOROMETHANE- & BETA-D-MANNOPYRANOSE 1,3,4,6-TETRA-O-AC& Mannose Triflate PLUS, ultra pure Mannose Triflate, ultra pure packing for GE Microlab Mannose Triflate, ultra pure packing for GE TRACERlab MXFDG Mannose Triflate, ultra pure 1,3,4,6-Tetra-O-Acetyl-2-O-(trifluoromethanesulfonyl)-a-D-mannopyranose Mannose triflate≥ 99%(GC) acetic acid [3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)-2-oxanyl]methyl ester TATM,1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose [(2R,3R,4S,5S,6S)-3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)oxan-2-yl]methyl acetate Mannose triflate C15H19F3O12S high quality Cas number：92051-23-5 Tetra-O-acetyl-mannose triflate CRS β-D-Mannopyranose, 1,3,4,6-tetraacetate 2-(trifluoromethanesulfonate) TATM USP/EP/BP 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose β-D-Mannopyranose1,3,4,6-tetra-O-acetate2-O-trifluoromethanesulfonate 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate-β-D-Mannopyranose (2S,3S,4S,5R,6R)-6-(Acetoxymethyl)-3-(((trifluoromethyl)sulfonyl)oxy)tetrahydro-2H-pyran-2,4,5-triyl triacetate MANNOSE TRIFLATE 1,3,4,6-tetra-O-acetyl-2-O-triflat-beta-D-mannopyr Mannose Triflate?New 1,3,4,6-Tetrα-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose