Methyl 4-chloro-3-nitrobenzoate
- CAS No.
- 14719-83-6
- Chemical Name:
- Methyl 4-chloro-3-nitrobenzoate
- Synonyms
- BUTTPARK 97\04-24;RARECHEM AL BF 0170;Methyl 4-chloro-3-ni;Intedanib Impurity 2;OTAVA-BB BB0128620049;Nintedanib impurities7;Methyl 4-chloro-3-nitrobenzate;METHYL 4-CHLORO-3-NITROBENZOATE;METHYL-3-NITRO-4-CHLOROBENZOATE;4-chloro-2-methyl-3-nitrobenzoate
- CBNumber:
- CB7775770
- Molecular Formula:
- C8H6ClNO4
- Molecular Weight:
- 215.59
- MDL Number:
- MFCD00016989
- MOL File:
- 14719-83-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| METHYL 4-CHLORO-3-NITROBENZOATE AldrichCPR | S706744 | 50MG | $152 |
| Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | M1779 | 5g | $32 |
| Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | M1779 | 25g | $95 |
| Methyl 4-Chloro-3-nitrobenzoate | M295765 | 1g | $55 |
| Methyl 4-Chloro-3-nitrobenzoate | JK581532 | 5g | $64 |
| More product size | |||
| Melting point | 80 °C |
|---|---|
| Boiling point | 313.2±22.0 °C(Predicted) |
| Density | 1.5220 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Light yellow to Green |
| Water Solubility | Soluble in water. |
| BRN | 1643729 |
| InChI | InChI=1S/C8H6ClNO4/c1-14-8(11)5-2-3-6(9)7(4-5)10(12)13/h2-4H,1H3 |
| InChIKey | XRTKWPWDSUNLHS-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 |
| CAS DataBase Reference | 14719-83-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-37 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
Methyl 4-chloro-3-nitrobenzoate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S706744 | METHYL 4-CHLORO-3-NITROBENZOATE AldrichCPR | 14719-83-6 | 50MG | $152 | 2026-04-30 | Buy |
| TCI Chemical | M1779 | Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | 14719-83-6 | 5g | $32 | 2026-04-30 | Buy |
| TCI Chemical | M1779 | Methyl 4-Chloro-3-nitrobenzoate >98.0%(GC) | 14719-83-6 | 25g | $95 | 2026-04-30 | Buy |
| TRC | M295765 | Methyl 4-Chloro-3-nitrobenzoate | 14719-83-6 | 1g | $55 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK581532 | Methyl 4-Chloro-3-nitrobenzoate | 14719-83-6 | 5g | $64 | 2021-12-16 | Buy |
Methyl 4-chloro-3-nitrobenzoate Chemical Properties,Uses,Production
Uses
Methyl 4-chloro-3-nitrobenzoate, is used as starting material for the preparation of the methyl benzoates
Synthesis
67-56-1
96-99-1
14719-83-6
Procedure for the synthesis of methyl 4-chloro-3-nitrobenzoate (1): 4-chloro-3-nitrobenzoic acid (5.0 g, 24.8 mmol) was dissolved in 200 mL of methanol and 4.15 mL (29.8 mmol) of triethylamine was added. The reaction mixture was cooled in an ice-salt bath and 3.19 mL (44.7 mmol) of acetyl chloride was added slowly and dropwise. The reaction mixture was stirred under reflux conditions for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 100 mL of water and then extracted twice with ethyl acetate (100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was recrystallized with ether (10 mL) to give white crystals of methyl 4-chloro-3-nitrobenzoate (4.81 g, 92% yield). Thin Layer Chromatography (TLC) Rf = 0.55 (unfolding agent: ethyl acetate/cyclohexane = 7/3); melting point 79-80 °C. Infrared spectroscopy (IR) showed the carbonyl absorption peak located at 1716 cm-1; 1H NMR spectrum (300 MHz, DMSO-d6) δ 3.90 (single peak, 3H, OCH3), 7.90 (double peak, 1H, H5, J5-6 = 8.1 Hz), 8.15 (double-double peak, 1H, H6, J6-5 = 8.1 Hz, J5-2 = 1.5 Hz ), 8.49 (double peaks, 1H, H2, J2-6 = 1.5Hz). Molecular formula: C8H6ClNO4.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3927 - 3936
[2] Heterocyclic Communications, 2001, vol. 7, # 5, p. 455 - 460
[3] Chemical Research in Toxicology, 1997, vol. 10, # 4, p. 439 - 449
[4] Synthetic Communications, 2002, vol. 32, # 11, p. 1703 - 1707
[5] Journal of Organic Chemistry, 2003, vol. 68, # 14, p. 5525 - 5533
Methyl 4-chloro-3-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 454 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from Methyl 4-chloro-3-nitrobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | Methyl 4-chloro-3-nitrobenzoate
14719-83-6
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- Methyl 4-chloro-3-nitrobenzoate
14719-83-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
