Z-FY-CHO
- CAS No.
- 167498-29-5
- Chemical Name:
- Z-FY-CHO
- Synonyms
- Z-FY-CHO;Z-Phe-Tyr-al;Z-PHE-TYR-CHO;Z-PHE-TYR-ALDEHYDE;Z-L-PHE-L-TYR-ALDEHYDE;CATHEPSIN L INHIBITOR II;Cathepsin L inhibitor inhibitor;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
- CBNumber:
- CB7776924
- Molecular Formula:
- C26H26N2O5
- Molecular Weight:
- 446.49
- MDL Number:
- MFCD00942274
- MOL File:
- 167498-29-5.mol
| Boiling point | 726.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | -15°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml) |
| form | solid |
| pka | 9.87±0.15(Predicted) |
| color | Off-white to pale yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| FDA UNII | U433S6RM7M |
Z-FY-CHO price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 219426 | Cathepsin L Inhibitor II The Cathepsin L Inhibitor II controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. | 5MG | $113 | 2024-03-01 | Buy | |
| Cayman Chemical | 23249 | Cathepsin L Inhibitor ≥95% | 167498-29-5 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 23249 | Cathepsin L Inhibitor ≥95% | 167498-29-5 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 23249 | Cathepsin L Inhibitor ≥95% | 167498-29-5 | 10mg | $197 | 2024-03-01 | Buy |
| Cayman Chemical | 23249 | Cathepsin L Inhibitor ≥95% | 167498-29-5 | 25mg | $456 | 2024-03-01 | Buy |
Z-FY-CHO Chemical Properties,Uses,Production
Description
Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over ?cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic ?pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2
Uses
Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease.
References
1) Woo et al. (1995), Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L; Bioorg. Med. Chem. Lett., 5 1501 2) Woo et al. (1996), Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo; Eur. J. Pharmacol., 300 131 3) James et al. (2001) Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resoption in vitro; J. Biol. Chem., 276 11507 4) Kaasik et al. (2005), Up regulation if lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium; Eur. J. Neurosci., 22 1023
Z-FY-CHO Preparation Products And Raw materials
Raw materials
Preparation Products
Z-FY-CHO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai GL Peptide Ltd. | +86-21-61263310; 13764994101 13764994101 | fisherwang@glschina.com | China | 8456 | 55 |
| Kanghua (Shanghai) New Drug Development Co., Ltd. | 021-61263370 18901917034 | xingli@glbiochem.com | China | 5637 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |