AG 490
- CAS No.
- 134036-52-5
- Chemical Name:
- AG 490
- Synonyms
- AG 490;(E/Z)-AG490;TYRPHOSTIN B42;AG 490 USP/EP/BP;TYROPHOSTIN AG490;TYRPHOSTIN AG 490;(E/Z)-Tyrphostin B42;AG 490, Tryphostin B42;(E/Z)-Tyrphostin AG490;TYRPHOSTIN AG 490, 99+%
- CBNumber:
- CB7779213
- Molecular Formula:
- C17H14N2O3
- Molecular Weight:
- 294.3
- MDL Number:
- MFCD00209833
- MOL File:
- 134036-52-5.mol
| Melting point | 215 |
|---|---|
| Boiling point | 615.2±55.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | ethanol: 5 mg/mL |
| pka | 8.82±0.35(Predicted) |
| form | solid |
| color | yellow |
| CAS DataBase Reference | 134036-52-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-50-25 |
| Safety Statements | 26-36-61-45 |
| WGK Germany | 1 |
| Hazard Note | Irritant/Keep Cold under -20C |
| HS Code | 2926907090 |
AG 490 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J61715 | Tyrphostin B42, 99+% | 134036-52-5 | 25mg | $178 | 2021-12-16 | Buy |
| Alfa Aesar | J61715 | Tyrphostin B42, 99+% | 134036-52-5 | 100mg | $329 | 2021-12-16 | Buy |
| Tocris | 0414 | AG 490 ≥99%(HPLC) | 134036-52-5 | 50 | $520 | 2021-12-16 | Buy |
| Tocris | 0414 | AG 490 ≥99%(HPLC) | 134036-52-5 | 10 | $124 | 2021-12-16 | Buy |
| Usbiological | T9250-15 | Tyrphostin AG 490 | 134036-52-5 | 25mg | $239 | 2021-12-16 | Buy |
AG 490 Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow-Green Crystal
Uses
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Uses
Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.
Definition
ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.
AG 490 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |