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CHMFL-KIT-033

CHMFL-KIT-033 Structure
CHMFL-KIT-033 structure
CAS No.
2351801-41-5
Chemical Name:
CHMFL-KIT-033
Synonyms
CHMFL-KIT-033;CHMFL KIT 033,CHMFLKIT033;Propanediamide, N1-(3-fluorophenyl)-N3-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-
CBNumber:
CB78054350
Molecular Formula:
C23H18FN5O2
Molecular Weight:
415.42
MDL Number:
MFCD32067971
MOL File:
2351801-41-5.mol
Last updated:2023-05-21 10:59:17
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CHMFL-KIT-033 Properties

Boiling point 772.4±60.0 °C(Predicted)
Density 1.451±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 7.28±0.70(Predicted)

CHMFL-KIT-033 Chemical Properties,Uses,Production

Description

CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM[1]. IC50: 0.045 μM (c-KIT T670I mutant)[1]

References

[1]. Liu X, et al. Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). J Med Chem. 2019 May 23;62(10):5006-5024.

CHMFL-KIT-033 Preparation Products And Raw materials

Raw materials

Preparation Products

CHMFL-KIT-033 Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
CHMFL-KIT-033 CHMFL KIT 033,CHMFLKIT033 Propanediamide, N1-(3-fluorophenyl)-N3-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]- 2351801-41-5