SC-514
- CAS No.
- 354812-17-2
- Chemical Name:
- SC-514
- Synonyms
- SC-514;CS-707;GK01140;GK-01140;GK 01140;SC-514, >=98%;SC-514;GK 01140;SC-514 USP/EP/BP;IKK-2 Inhibitor, SC-514;4-Amino-[2,3']bithiophenyl-5-carboxamide
- CBNumber:
- CB7832024
- Molecular Formula:
- C9H8N2OS2
- Molecular Weight:
- 224.3
- MDL Number:
- MFCD00206459
- MOL File:
- 354812-17-2.mol
| Melting point | 209-211°C |
|---|---|
| Boiling point | 399.2±42.0 °C(Predicted) |
| Density | 1.450±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 15.63±0.50(Predicted) |
| form | powder |
| color | white to light brown |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | EU3S753TY9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SC-514 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0557 | SC-514 ≥97% (HPLC) | 354812-17-2 | 5mg | $93.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 401479 | IKK-2 Inhibitor, SC-514 | 354812-17-2 | 1mg | $144 | 2024-03-01 | Buy |
| Cayman Chemical | 10010267 | SC-514 ≥98% | 354812-17-2 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 10010267 | SC-514 ≥98% | 354812-17-2 | 10mg | $78 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0557 | SC-514 ≥97% (HPLC) | 354812-17-2 | 25mg | $289 | 2024-03-01 | Buy |
SC-514 Chemical Properties,Uses,Production
Description
SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1
Chemical Properties
Yellow Solid
Uses
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 for IKK-2 homodimer, IKK-1/IKK-2 heterodimer,
Uses
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
Definition
ChEBI: 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a ring assembly and a member of thiophenes.
storage
Store at +4°C
References
1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861
SC-514 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
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