2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
- CAS No.
- 61500-87-6
- Chemical Name:
- 2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
- Synonyms
- 2-amino-4-(trifluoromethyl)benzoate;Methyl 2-amino-4-(trifluoromethyl)benzoate;Methyl 2-aMino-3-chloro-5-trifluoroMethoxybenzoate;2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER;2-Amino-4-trifluoromethyl-benzoic acid methyl ester 97%;Benzoic acid, 2-aMino-4-(trifluoroMethyl)-, Methyl ester
- CBNumber:
- CB7837216
- Molecular Formula:
- C9H8F3NO2
- Molecular Weight:
- 219.16
- MDL Number:
- MFCD08543939
- MOL File:
- 61500-87-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2-Amino-4-(trifluoromethyl)benzoate | M2905 | 1G | $65 |
| Methyl 2-Amino-4-(trifluoromethyl)benzoate | M2905 | 5G | $245 |
| 2-Amino-4-trifluoromethylbenzoicAcidMethylEster | A630885 | 25g | $275 |
| Methyl 2-Amino-4-(trifluoromethyl)benzoate | X2838 | 100g | $917 |
| Methyl 2-amino-4-(trifluoromethyl)benzoate 95+% | 074618 | 5g | $998 |
| More product size | |||
| Melting point | 65-68 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
|---|---|
| Boiling point | 267.5±40.0 °C(Predicted) |
| Density | 1.343±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 1.06±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C9H8F3NO2/c1-15-8(14)6-3-2-5(4-7(6)13)9(10,11)12/h2-4H,13H2,1H3 |
| InChIKey | DZICUHOFOOPVFM-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(C(F)(F)F)C=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2905 | Methyl 2-Amino-4-(trifluoromethyl)benzoate | 61500-87-6 | 1G | $65 | 2025-07-31 | Buy |
| TCI Chemical | M2905 | Methyl 2-Amino-4-(trifluoromethyl)benzoate | 61500-87-6 | 5G | $245 | 2025-07-31 | Buy |
| TRC | A630885 | 2-Amino-4-trifluoromethylbenzoicAcidMethylEster | 61500-87-6 | 25g | $275 | 2021-12-16 | Buy |
| AK Scientific | X2838 | Methyl 2-Amino-4-(trifluoromethyl)benzoate | 61500-87-6 | 100g | $917 | 2021-12-16 | Buy |
| Matrix Scientific | 074618 | Methyl 2-amino-4-(trifluoromethyl)benzoate 95+% | 61500-87-6 | 5g | $998 | 2021-12-16 | Buy |
2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
2-Amino-4-trifluoromethylbenzoic Acid Methyl Ester is an intermediate used to prepare quinazolinedione sulfonamides as competitive AMPA receptor antagonists. It is also used in the synthesis of (arylamino)pyrimidobenzazepinones and pyrimidobenzazepinethiones as inhibitors of polo-like kinase 1 and potential antitumor agents.
Synthesis
228418-45-9
61500-87-6
Step 2; Preparation of methyl 2-amino-4-trifluoromethylbenzoate; Methyl 2-nitro-4-(trifluoromethyl)benzoate (106 g, 425 mmol) was dissolved in ethanol. To a slurry of 10% palladium carbon (11.0 g) in ethyl acetate (200 mL) was added ethyl acetate (2.2 L), and the suspension was stirred for 3 h at room temperature and 60 °C under a hydrogen atmosphere. Upon completion of the reaction, the suspension was filtered through a Celite pad and the pad was washed with additional ethyl acetate. The filtrate was concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using isohexane/ethyl acetate (9:1) as eluent to afford methyl 2-amino-4-trifluoromethylbenzoate as a white crystalline solid (84 g, 95% yield).
References
[1] Patent: WO2006/2342, 2006, A1. Location in patent: Page/Page column 55-56
[2] Patent: US2004/102636, 2004, A1
[3] Patent: US2008/269265, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: EP1449834, 2004, A2. Location in patent: Page 16
[5] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 21
2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14359 | 58 |
View Lastest Price from 2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-12 | 2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
61500-87-6
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
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- 2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
61500-87-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
