9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]-
![9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Structure](CAS/20210111/GIF/714971-87-6.gif)
- CAS No.
- 714971-87-6
- Chemical Name:
- 9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]-
- Synonyms
- Ro0711401;N-(4-(Trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide;9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]-;Ro0711401,Metabotropic glutamate receptors,mGluR,oral,PAM,Inhibitor,mGlu1,inhibit
- CBNumber:
- CB78374111
- Molecular Formula:
- C18H11F3N2O3
- Molecular Weight:
- 360.29
- MDL Number:
- MFCD31692711
- MOL File:
- 714971-87-6.mol
9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Chemical Properties,Uses,Production
Biological Activity
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2]. RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days[1].Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice[1].
References
[1]. Serena Notartomaso, et al. Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Mol Brain. 2013 Nov 19;6:48. [2]. Eric Vieira, et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9.
9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
9H-Xanthene-9-carboxamide, N-[4-(trifluoromethyl)-2-oxazolyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9838 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 884 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 3362556465@qq.com | China | 8000 | 58 |
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| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2992 | 58 |