A 205804
- CAS No.
- 251992-66-2
- Chemical Name:
- A 205804
- Synonyms
- CS-635;A 205804;A-205804;A 205804;A 205804 USP/EP/BP;A205804;A 205804;A-205804;IKK-16 (IKK Inhibitor VII);4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
- CBNumber:
- CB7838925
- Molecular Formula:
- C15H12N2OS2
- Molecular Weight:
- 300.4
- MDL Number:
- MFCD09038566
- MOL File:
- 251992-66-2.mol
| Melting point | 198-199℃ |
|---|---|
| Boiling point | 581.3±45.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | powder to crystal |
| pka | 15.12±0.30(Predicted) |
| color | White to Orange to Green |
| FDA UNII | TP7TB1SSZD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2934.99.9001 | |||||||||
| NFPA 704 |
|
A 205804 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3498 | 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide >95.0%(HPLC) | 251992-66-2 | 25mg | $178 | 2024-03-01 | Buy |
| TCI Chemical | T3498 | 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide >95.0%(HPLC) | 251992-66-2 | 100mg | $488 | 2024-03-01 | Buy |
| Cayman Chemical | 21252 | A-205804 ≥95% | 251992-66-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21252 | A-205804 ≥95% | 251992-66-2 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 21252 | A-205804 ≥95% | 251992-66-2 | 10mg | $130 | 2024-03-01 | Buy |
A 205804 Chemical Properties,Uses,Production
Description
A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).
Uses
4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.
Definition
ChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.
Biological Activity
Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
storage
Store at +4°C
References
[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.
A 205804 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |