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ChemicalBook >> CAS DataBase List >>Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-

Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-

Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Structure
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- structure
CAS No.
2522599-79-5
Chemical Name:
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-
Synonyms
CAY10771;CAY-10771,CAY10771;4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-benzeneacetic acid;Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-
CBNumber:
CB78435731
Molecular Formula:
C28H25Cl3N2O4
Molecular Weight:
559.87
MDL Number:
MOL File:
2522599-79-5.mol
Last updated:2023-06-08 09:03:02
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Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Properties

Boiling point 706.8±60.0 °C(Predicted)
Density 1.368±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Acetonitrile: 5 mg/ml
pka 4.57±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Chemical Properties,Uses,Production

Biological Activity

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1 It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM.

References

1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)

Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Suppliers

Global( 6)Suppliers
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Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Changzhou Furuisi Biotechnology Co., Ltd 58
ChemeGen 中国 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- CAY10771 CAY-10771,CAY10771 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-benzeneacetic acid 2522599-79-5