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4-Nitrophenol structure
Chemical Name:
HONP;Niphen;NSC 1317;NCI-C55992;Nirtrphenol;4-Nitrofenol;p-Nitrofenol;4-Nitrophenol;4-nitro-pheno;p-nitro-pheno
Molecular Formula:
Formula Weight:
MOL File:

4-Nitrophenol Properties

Melting point:
112 °C
Boiling point:
279 °C(lit.)
1,27 g/cm3
vapor pressure 
0.6 mm Hg ( 120 °C)
refractive index 
1.5723 (estimate)
Flash point:
169 °C
storage temp. 
Store in dark!
ethanol: soluble95%, clear, dark yellow (100 mg/mL)
7.15(at 25℃)
Crystalline Powder, Crystals and/or Chunks
Yellow to brown
Specific Gravity
PH Range
4.4 (5g/l, H2O, 24℃)(anhydrous substance)
Water Solubility 
1.6 g/100 mL (25 ºC)
Light Sensitive
320nm, 405nm
Stable. Incompatible with strong oxidizing agents, strong bases, organics, combustible material, reducing agents. Combustible.
Major Application
Display device, solar cells, nanoparticles, electrolytic capacitors, lithographic printing plate, leak detection method, falsification-proof security paper, correction fluid, detergent, fertilizer, identifying fresh and stale rice, diapers, detecting lactic acid bacteria, drug delivery, evaluating dental caries activity
CAS DataBase Reference
100-02-7(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 4-nitro-(100-02-7)
EPA Substance Registry System
Phenol, 4-nitro-(100-02-7)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  20/21/22-33-39/23/24/25-23/24/25-11
Safety Statements  28-28A-45-36/37-16-7
RIDADR  UN 1663 6.1/PG 3
WGK Germany  2
RTECS  SM2275000
Autoignition Temperature 541 °F
HazardClass  6.1
PackingGroup  III
HS Code  29089000
Hazardous Substances Data 100-02-7(Hazardous Substances Data)
Toxicity LD50 orally in mice, rats: 467, 616 mg/kg, K.C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

4-Nitrophenol price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1048 4-Nitrophenol spectrophotometric grade 100-02-7 5g $48.4 2018-11-13 Buy
Sigma-Aldrich 1003064 Acetaminophen Related Compound F United States Pharmacopeia (USP) Reference Standard 100-02-7 50mg $1117.2 2018-11-13 Buy
TCI Chemical N0161 4-Nitrophenol (0.25% in Water) [for pH Determination] 100-02-7 500mL $77 2018-11-22 Buy
Alfa Aesar A14376 4-Nitrophenol, 99% 100-02-7 250g $21.5 2018-11-13 Buy
Alfa Aesar A14376 4-Nitrophenol, 99% 100-02-7 1000g $51.9 2018-11-13 Buy

4-Nitrophenol Chemical Properties,Uses,Production

Chemical Properties

Yellow to tan crystals or powder


Used in the manufacturing of pharmaceuticals, fungicides, dyes.


manufacture of pharmaceuticals, fungicides, dyes. Indicator in 0.1% alcohol solution. pH: 5.6 colorless, 7.6 yellow.


ChEBI: A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.

General Description

A white to light yellow crystalline solid. Contact may severely irritate skin and eyes. Poisonous by ingestion and moderately toxic by skin contact.

Air & Water Reactions

Soluble in hot water and more dense than water.

Reactivity Profile

4-Nitrophenol is a slightly yellow, crystalline material, moderately toxic. Mixtures with diethyl phosphite may explode when heated. Decomposes exothermally, emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Decomposes violently at 279°C and will burn even in absence of air [USCG, 1999]. Solid mixtures of the nitrophenol and potassium hydroxide (1:1.5 mol) readily deflagrate [Bretherick, 5th Ed., 1995].


Toxic by ingestion.

Health Hazard

Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes or skin causes irritation; can be absorbed through skin to give same symptoms as for inhalation.

Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and intramuscular routes. Moderately toxic by skin contact. Human mutation data reported. Its exothermic decomposition causes a dangerously fast pressure increase. Murtures with diethyl phosphite may explode when heated. When heated to decomposition it emits toxic fumes of NOx. See also other nitrophenol entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Metabolic pathway

4-[U-14C]Nitrophenol is conjugated as its b-glucoside (ca 22% of applied 14C) and gentiobioside, glc- b(126)-glc-b-4-nitrophenol (ca 64%), while about 7% of the parent remains unchanged in cell suspension cultures of Datura stramonium (L.). Gal-b-4-nitrophenol is found to be a minor metabolite.

Purification Methods

Crystallise 4-nitrophenol from water (which may be acidified, e.g. with N H2SO4 or 0.5N HCl), EtOH, aqueous MeOH, CHCl3, *benzene or pet ether, then dry it in vacuo over P2O5 at 25o. It can be sublimed at 60o/10-4mm. The 4-nitrobenzoate had m 159o (from EtOH). [Beilstein 6 IV 1279.]

4-Nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

4-Nitrophenol Suppliers

Global( 307)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19953 60
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+86-371-55531817 CHINA 22043 58
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0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
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Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20229 58
Haihang Industry Co.,Ltd
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View Lastest Price from 4-Nitrophenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-30 4-Nitrophenol
US $20.00-20.00 / KG 100KG 99% 1000kg career henan chemical co

4-Nitrophenol Spectrum

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