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Heptanoic acid

CAS No.
111-14-8
Chemical Name:
Heptanoic acid
Synonyms
N-HEPTANOIC ACID;C7;ENANTHIC ACID;heptanoic;HEPTYLIC ACID;OENANTHIC ACID;Enanthoic Acid;FEMA 3348;hexacidc-7;Amylacetat
CBNumber:
CB7852833
Molecular Formula:
C7H14O2
Molecular Weight:
130.18
MDL Number:
MFCD00004426
MOL File:
111-14-8.mol
MSDS File:
SDS
Last updated:2023-11-28 16:31:43

Heptanoic acid Properties

Melting point -10.5 °C (lit.)
Boiling point 223 °C (lit.)
Density 0.918 g/mL at 25 °C (lit.)
vapor density 4.5 (vs air)
vapor pressure <0.1 mm Hg ( 20 °C)
FEMA 3348 | HEPTANOIC ACID
refractive index n20/D 1.4221(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility water: soluble0.2419 g/100ml at 15°C
pka 4.89(at 25℃)
form Powder
color White to off-white
Odor at 1.00 % in propylene glycol. rancid sour cheesy sweat
Odor Type cheesy
explosive limit 10.1%
Water Solubility 0.24 g/100 mL (15 ºC)
Merck 14,4660
JECFA Number 96
BRN 1744723
Dielectric constant 2.5(22℃)
Stability Stable. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible. Protect from light.
InChIKey MNWFXJYAOYHMED-UHFFFAOYSA-N
LogP 2.54 at 20℃
Substances Added to Food (formerly EAFUS) HEPTANOIC ACID
CAS DataBase Reference 111-14-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII THE3YNP39D
NIST Chemistry Reference Heptanoic acid(111-14-8)
EPA Substance Registry System Heptanoic acid (111-14-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H335
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310
Hazard Codes  C
Risk Statements  34
Safety Statements  26-28-36/37/39-45-28A
RIDADR  UN 3265 8/PG 3
WGK Germany  1
RTECS  MJ1575000
Autoignition Temperature 380 °C
TSCA  Yes
HS Code  2915 90 70
HazardClass  8
PackingGroup  III
Toxicity LD50 i.v. in mice: 1200±56 mg/kg (Or, Wretlind)
NFPA 704
0
3 0

Heptanoic acid price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W334812 Heptanoic Acid natural, FG 111-14-8 100g $88.3 2024-03-01 Buy
Sigma-Aldrich W334812 Heptanoic Acid natural, FG 111-14-8 1kg $367 2024-03-01 Buy
Sigma-Aldrich W334804 Heptanoic Acid 97%, FG 111-14-8 1kg $70.8 2024-03-01 Buy
Sigma-Aldrich W334804 Heptanoic Acid 97%, FG 111-14-8 10Kg $266 2024-03-01 Buy
Sigma-Aldrich W334804 Heptanoic Acid 97%, FG 111-14-8 20kg $469 2024-03-01 Buy
Product number Packaging Price Buy
W334812 100g $88.3 Buy
W334812 1kg $367 Buy
W334804 1kg $70.8 Buy
W334804 10Kg $266 Buy
W334804 20kg $469 Buy

Heptanoic acid Chemical Properties,Uses,Production

Description

As an organic compound, heptanoic acid is a seven-carbon linear chain saturated fatty acid with an unpleasant, rancid and pungent odor, which is commonly used as a chemical intermediate in the synthesis of esters for products, such as ethyl heptanoate, that are used in fragrances and artificial flavors. It is also applied in cosmetics for the production of emollients, skin conditioning agents as well as viscosity controlling agents. Besides, heptanoic acid can also act as a industrial lubricant applied in the fields of aviation, refrigeration, automobile, etc. due to its low viscosity at low temperature and low volatility at high temperature. Moreover, the good anti-corrosion property of heptanoic acid results in the usage of metalworking fluids, industrial water-based refrigerants and anti-corrosion additive for paint. Heptanoic acid is also applied to esterify steroids in the field of pharmaceutical to produce drugs such as testosterone enanthate, trenbolone enanthate, drostanolone enanthate, methenolone enanthate and it is also one of numerous additives in cigarettes.

References

https://en.wikipedia.org/wiki/Heptanoic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/8094#section=Top
http://www.arkema.com/en/products/product-finder/product-viewer/Oleris-n-Heptanoic-acid/

Description

Heptanoic acid, also called enanthic acid, is an organic compound composed of a seven - carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It contributes to the odor of some rancid oils. It is slightly soluble in water, but very soluble in ethanol and ether.

Chemical Properties

Heptanoic acid has a disagreeable rancid odor. The spectroscopically pure acid exhibits a faint tallow-like odor. Heptanoic acid may be prepared by oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid.

Occurrence

Reported as occurring naturally in calamus, hops, Acacia dealbata, and Japanese peppermint and violet leaves; its presence in rancid oils has been observed Also reported found in passion fruit, mandarin orange peel oil, guava, apple, banana, grapes, papaya, raspberry, strawberry, kiwi, baked potato, sauerkraut, tomato, breads, cheeses, butter, milk, fsh, fsh oil, meats, chicken fat, pork fat, hop oil, beer, cognac, brandy, rum, grape wines, sherry, whiskies, sake, peated malt, cocoa, coffee, tea, soy protein, peanuts, pecans, coconut, beans, mushroom, fenugreek, mango, fgs, licorice, corn oil, shrimps, scallops and other sources

Uses

There are two major uses for heptanoic acid. One is in vinyl plasticizers that are used primarily in the automotive market.This market is expected to grow 3 to 4% per year with GNP.The second is in synthetic lubricants, where heptanoic acid is used in polyol esters.The market for polyol esters is primarily for use in commercial and military jet turbine lubricants.There is a small market for these esters in the automotive lubricant area, but there has been limited acceptance of these products by automakers and the public.The growth of the polyol ester market is expected to track GNP, unless automakers change to support synthetics or unless there is an elevation of military activity.
The use of heptanoic acid in high-water metalworking fluids has grown in excess of 20% over the last several years.The amount of acid used in these products is small; therefore, a dramatic change from the traditional oil-based fluids would be required before there would be significant market impact.

Uses

Heptanoic acid is used as an organic building block for the synthesis of a variety of chemical compounds. It is involved in the esterification of steroids and used in the preparation of active pharmaceutical ingredients such as trenbolone enanthate, testosterone enanthate, drostanolone enanthate and methenolone enanthate. It is also used as an internal standard during gas chromatography analysis of the butyl esters of volatile acids. Its ester derivatives are used in the fragrance and flavor industries as well as cosmetics and industrial lubricants in aviation, refrigeration and automobile. It is used to prepare sodium heptanoate, which is used as a corrosion inhibitor.

Definition

ChEBI: A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes.

Production Methods

The methyl ester of ricinoleic acid, obtained from castor bean oil is the main commercial precursor to heptanoic acid. It is hydrolyzed to the methyl ester of [[undecenoic acid]] and heptanal, which is then air oxidized to the carboxylic acid. Approximately 20,000 tons were consumed in Europe and US in 1980.
Ricinoleic acid is the main precursor to heptanoic acid. Heptanoic acid is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. Heptanoic acid is used to esterify steroids in the preparation of drugs such as as testosterone enanthate, trenbolone enanthate, drostanolone enanthate and methenolone enanthate (Primobolan). It is also one of many additives in cigarettes.

Preparation

By oxidation of heptaldehyde with potassium permanganate in diluted sulfuric acid.

Taste threshold values

Taste characteristics at 5 ppm: waxy, cheesy, fruity, dirty and fatty.

Synthesis Reference(s)

Tetrahedron Letters, 21, p. 2181, 1980 DOI: 10.1016/S0040-4039(00)78992-1
The Journal of Organic Chemistry, 58, p. 4745, 1993 DOI: 10.1021/jo00069a047

General Description

A colorless liquid with a pungent odor. Less dense than water and poorly soluble in water. Hence floats on water. Very corrosive. Contact may likely burn skin, eyes, and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Flash point near 200°F.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Heptanoic acid reacts exothermically with bases. Can react, particularly if moist, with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow if the acid remains dry. Corrodes or dissolves iron, steel, and aluminum parts and containers under ordinary conditions. Reacts with cyanide salts to generate gaseous hydrogen cyanide, particuarly if moist. May generate flammable and/or toxic gases with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts exothermically with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced exothermically by strong reducing agents. A wide variety of products is possible. May initiate polymerization reactions; may catalyze chemical reactions.

Hazard

Combustible.

Health Hazard

Harmful if swallowed, inhaled, or absorbed through skin. Extremely destructive to mucous membranes, upper respiratory tract, skin, and eyes. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Fire Hazard

Heptanoic acid is probably combustible.

111-70-6
111-14-8
Synthesis of Heptanoic acid from 1-Heptanol
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View Lastest Price from Heptanoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Heptanoic acid pictures 2024-03-19 Heptanoic acid
111-14-8
US $5.00 / kg 1kg ≥95% 5000mt/year Jinan Finer Chemical Co., Ltd
Heptanoic acid pictures 2023-08-18 Heptanoic acid
111-14-8
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Heptanoic acid pictures 2023-03-16 Heptanoic acid
111-14-8
US $20.00 / kg 1kg 99% 5000 Ton Hebei Duling International Trade Co. LTD
  • Heptanoic acid pictures
  • Heptanoic acid
    111-14-8
  • US $5.00 / kg
  • ≥95%
  • Jinan Finer Chemical Co., Ltd
  • Heptanoic acid pictures
  • Heptanoic acid
    111-14-8
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Heptanoic acid pictures
  • Heptanoic acid
    111-14-8
  • US $20.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
Heptansαure Hepthlic acid Heptoic acid heptoicacid Heptylsαure Hexacid C-7 hexacidc-7 n-heptanoic n-Heptoic acid n-heptoicacid 1-Hexanecarboxylic acid 1-Hexanecarboxylic acid ate RARECHEM AL BO 0434 N-HEPTYLIC ACID C7:0 FATTY ACID CARBOXYLIC ACID C7 HEPTANOIC ACID FEMA 3348 1-HEPTANOIC ACID Eneantyic acid Heptanoic Acid Food Garde HEPTANOIC ACID 98+% NATURAL HEPTANOIC ACID 96% HEPTANOIC ACID 97+% HEPTANOIC ACID, GC STANDARD Heptanoic acid, 98+% Heptanoic Acid-D13 Heptanoic acid >=99.0% (GC) Heptanoic acid, AR,98.0% Heptanoic acid≥ 99% (GC) HEPTANOIC ACID, NATURAL Enanthic acid, Oenanthic acid n-Heptansure OENANTHSAEURE Enanthic acid Heptanoic acid N-OENANTHICACID(ENANTHYLICACID.HEPTANOICACID) 1-hexanecarboxylicacid acideheptanoique acideheptylique Amylacetat Enanthylic acid enanthylicacid Oenanthsαure Oenanthylic acid oenanthylicacid Heptanoic acid ,99% Hepthylic acid Heptanoic acid (Enanthic) heptanoic acid >=99.0% Heptanoic acid,Enanthic acid, Oenanthic acid Heptanoic acid, 98% 1LT Heptanoic acid, 98% 250ML HEPTANOIC ACID FOR SYNTHESIS 100 ML HEPTANOIC ACID FOR SYNTHESIS 500 ML Heptanoic acid, Standard for GC Heptanoic acid 111-14-8 Manufacturer High quality Best price In stock factory Enanthic acid 111-14-8 Heptanoic acid 111-14-8 Enanthic acid 111-14-8 Natural Heptanoic Acid