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Propionic anhydride

Preparation Application
Propionic anhydride
Propionic anhydride structure
Chemical Name:
Propionic anhydride
propionic;propionyloxide;Propionyl oxide;C2H5C(O)OC(O)C2H5;Propinoicanhydride;Propanic Anhydride;Propionic Anhydried;PROPIONIC ANHYDRIDE;PROPANOIC ANHYDRIDE;Propionsureanhydrid
Molecular Formula:
Formula Weight:
MOL File:

Propionic anhydride Properties

Melting point:
-42 °C
Boiling point:
167 °C(lit.)
1.015 g/mL at 25 °C(lit.)
vapor density 
4.5 (vs air)
vapor pressure 
10 mm Hg ( 57.7 °C)
refractive index 
n20/D 1.404(lit.)
Flash point:
165 °F
storage temp. 
Store below +30°C.
H2O: decomposes (when in contact with water)
2.5 (100g/l, H2O, 20℃)(calculated on the free acid)
explosive limit
Water Solubility 
Moisture Sensitive
Stable. Combustible. Incompatible with strong oxidizing agents, water, moisture, most common metals, active halogen compounds, ammonia, amines.
CAS DataBase Reference
123-62-6(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, anhydride(123-62-6)
EPA Substance Registry System
Propanoic acid, anhydride(123-62-6)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  C
Risk Statements  34-R34
Safety Statements  26-45-S45-S26
RIDADR  UN 2496 8/PG 3
WGK Germany  1
RTECS  UF9100000
Autoignition Temperature 545 °F
Hazard Note  Corrosive/Moisture Sensitive
HS Code  2915 90 70
HazardClass  8
PackingGroup  III
Hazardous Substances Data 123-62-6(Hazardous Substances Data)
Toxicity LD50 orally in rats: 2.36 g/kg (Smyth)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
3 1
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)

(NFPA, 2010)

Propionic anhydride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 240311 Propionic anhydride ≥99% 123-62-6 50g $32.2 2018-11-13 Buy
Sigma-Aldrich 81942 Propionic anhydride purum, ≥96.0% (NT) 123-62-6 1l $59.6 2018-11-13 Buy
TCI Chemical P0513 Propionic Anhydride >98.0%(GC)(T) 123-62-6 25g $14 2018-11-22 Buy
TCI Chemical P0513 Propionic Anhydride >98.0%(GC)(T) 123-62-6 500g $34 2018-11-22 Buy
Alfa Aesar A12955 Propionic anhydride, 97% 123-62-6 250g $25.7 2018-11-13 Buy

Propionic anhydride Chemical Properties,Uses,Production


Propionic anhydride can be synthesized by dehydration of propanoic acid using ketene.
2 CH3CH2CO2H + CH2=C=O → (CH3CH2CO)2O + CH3CO2H


Propionic anhydride was previously used in the preparation of αand β-1-propionyl derivatives of glucopyranose tetra-acetate.


Propanoic anhydride is an organic compound with the formula (CH3CH2CO)2O. This simple acid anhydride is a colourless liquid. It is a widely used reagent in organic synthesis.

Chemical Properties

Propionic anhydride is a colorless liquid. Strong, pungent, unpleasant odor.

Chemical Properties

colourless liquid with an unpleasant odour


Usually used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate.


Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.

General Description

Propionic anhydride is an organic compound with the molecular formula (CH3CH2CO)2O. it is an colorless acid anhydride that is widely used as a reagent in organic synthesis.

Air & Water Reactions

Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].

Reactivity Profile

Propionic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.


Strong irritant to tissue.

Health Hazard

Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

Moderately toxic by ingestion. Mildly toxic by skin contact. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. Used as an esterifyng agent and dehydrating agent. See also ANHYDRIDES.


Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs.

Chemical Synthesis

Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene :
2 CH3CH2CO2H + CH2= C= O → (CH3CH2CO)2O + CH3CO2H.

Potential Exposure

Used in the manufacture of perfumes, flavorings, alkyd resins; dyestuffs, pharmaceuticals; as an esterifying agent for fats, oils, and cellulose; dehydrating medium for nitrations and sulfonations.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. If victim is conscious, administer water, or milk. Do not induce vomiting. Medical observation is recommended for 24?48 hours after breathing overexpo- sure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN2496 Propionic anhydride, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]


Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, perox- ides, permanganates, perchlorates, chlorine, bromine, fluo- rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, reducing agents; alcohols and metals. Contact with water forms heat 1 flammable propionic acid. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercap- tans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Propionic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

Propionic anhydride Suppliers

Global( 189)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20177 58
career henan chemical co
+86-371-86658258 CHINA 19975 58
Beijing Universal Century Technology Co., Ltd. 400-8706899
400-8706899 China 3669 55
Nanjing Zhipu Chemical Co., Ltd 025-83172869*83172967*18851668089*13813022170
025-83311492 China 30 55
Dalian Idery Biotechnology Co., Ltd. 0411-62696576/0411-66160116/15141125520
0411-66160116 China 85 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from Propionic anhydride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-20 Propionic anhydride
US $1.00 / kg 1kg 99% 500kg career henan chemical co

Propionic anhydride Spectrum

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