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4-Amino-1-butanol

CAS No.
13325-10-5
Chemical Name:
4-Amino-1-butanol
Synonyms
4-aminobutan-1-ol;BUTANOLAMINE;4-AMINOBUTANOL;SKL271;N-ABU(4)-OL;H-ABUT(4)-OL;NH2-(CH2)4-OH;4-Aminobutanol-1;2-AcetyLhiophene;4-AMINO-1-BUTANOL
CBNumber:
CB7853047
Molecular Formula:
C4H11NO
Molecular Weight:
89.14
MDL Number:
MFCD00008230
MOL File:
13325-10-5.mol
MSDS File:
SDS
Last updated:2024-02-28 11:08:11

4-Amino-1-butanol Properties

Melting point 16-18 °C (lit.)
Boiling point 206 °C (lit.)
Density 0.967 g/mL at 25 °C (lit.)
refractive index n20/D ~1.462(lit.)
Flash point 226 °F
storage temp. Store below +30°C.
solubility Acetonitrile (Slightly), Chloroform (Sparingly), Methanol (Slightly)
form Liquid
pka 15.10±0.10(Predicted)
color Clear colorless to slightly yellow
Water Solubility MISCIBLE
Sensitive Air Sensitive & Hygroscopic
BRN 1731411
Stability Unstable in Aqueous Solution
CAS DataBase Reference 13325-10-5(CAS DataBase Reference)
NIST Chemistry Reference NH2(CH2)4OH(13325-10-5)
EPA Substance Registry System 1-Butanol, 4-amino- (13325-10-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
Hazard Codes  C
Risk Statements  34-22
Safety Statements  26-36/37/39-45-25
RIDADR  UN 2735 8/PG 3
WGK Germany  3
34
HazardClass  8
PackingGroup  III
HS Code  29221980
NFPA 704
1
3 1

4-Amino-1-butanol price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 178330 4-Amino-1-butanol 98% 13325-10-5 1g $39.9 2024-03-01 Buy
Sigma-Aldrich 178330 4-Amino-1-butanol 98% 13325-10-5 5g $113 2024-03-01 Buy
TCI Chemical A1013 4-Amino-1-butanol >98.0%(GC) 13325-10-5 5g $69 2024-03-01 Buy
TCI Chemical A1013 4-Amino-1-butanol >98.0%(GC) 13325-10-5 25g $274 2024-03-01 Buy
Alfa Aesar A12680 4-Amino-1-butanol, 98% 13325-10-5 1g $38.5 2023-06-20 Buy
Product number Packaging Price Buy
178330 1g $39.9 Buy
178330 5g $113 Buy
A1013 5g $69 Buy
A1013 25g $274 Buy
A12680 1g $38.5 Buy

4-Amino-1-butanol Chemical Properties,Uses,Production

Description

4-Amino-1-butanol (4AB) is an important pharmaceutical intermediate compound and a precursor of biodegradable polymers for gene delivery. It can be used in organic synthesis and biological properties studies, among others. In addition, 4-Amino-1-butanol (4AB) has been shown to have a higher CO2 solubility than 2-amino-1-ethanol (MEA), which is potentially useful in solving problems related to flue gas purification[1-2].

Chemical Properties

Very light clear yellow liquid

Uses

4-Amino-1-butanol was used:

  • As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.
  • As a side chain to modulate antimicrobial and hemolytic activities of copolymers.
  • In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (?)-lycojapodine A.

Uses

4-Amino-1-butanol is a useful intermediate in a variety of organic synthesis. It is mainly used in personal-care products, preparation of water soluble cationic flocculants and ion exchange resins as well as in the preparation of beta-lactam antibiotics. It is used for the production of efficient anionic emulsifiers, nonionic polyethylene emulsions, water treatment, metal treatment and absorption of carbon dioxide gas. It is used as a pigment dispersion aid and curing agent in selected textile -resins.

Preparation

4-Amino-1-butanol (4AB) can be prepared by microbiological methods. we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase (encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production. Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7?g/L of 4AB[1].

References

[1] CINDY PRICILIA SURYA PRABOWO. Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol[J]. Biotechnology and Bioengineering, 2020. DOI:10.1002/bit.27438.
[2] ZULKIFLI IDRIS . Equilibrium solubility of carbon dioxide in aqueous solutions of 3-amino-1-propanol, 4-amino-1-butanol and 5-amino-1-pentanol at low partial pressures[J]. Fluid Phase Equilibria, 2015. DOI:10.1016/j.fluid.2014.11.028.

24697-70-9
13325-10-5
Synthesis of 4-Amino-1-butanol from 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione
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View Lastest Price from 4-Amino-1-butanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-1-butanol pictures 2023-06-15 4-Amino-1-butanol
13325-10-5
US $980.00 / KG 1KG 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.
4-Amino-1-butanol pictures 2023-05-12 4-Amino-1-butanol
13325-10-5
US $0.00-0.00 / kg 10kg 98% ton grade Suzhou Ryan Pharmachem Technology Co.,Ltd.
4-Amino-1-butanol pictures 2023-01-31 4-Amino-1-butanol
13325-10-5
US $100.00 / kg 1kg 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
  • 4-Amino-1-butanol pictures
  • 4-Amino-1-butanol
    13325-10-5
  • US $0.00-0.00 / kg
  • 98%
  • Suzhou Ryan Pharmachem Technology Co.,Ltd.
NH2-(CH2)4-OH N-ABU(4)-OL 4-HYDROXY-N-BUTYLAMINE 4-HYDROXYBUTYLAMINE 4-AMINO-1-BUTANOL 4-AMINOBUTYL ALCOHOL 4-AMINO-N-BUTYL ALCOHOL DELTA-AMINO-N-BUTYL ALCOHOL H-ABUT(4)-OL 4-Amino-1-Butanol98% 4-Aminobutane-1-ol 4-AMino-1-butanol, 98% 5GR 4-AMino-1-butanol 98% 1-Butanol, 4-amino- 4-Aminobutanol-1 4-hdyroxybutylamine 4-hydroxybutanamine H2NCH2(CH2)2CH2OH 4-hydroxybutylammonium 4-hydroxybutan-1-aminium 4-Amino-1-butanol > 4-AMINO-1-BUTANOL FOR SYNTHESIS 4-Amino-1-butanol USP/EP/BP SKL271 4-AMINOBUTANOL BUTANOLAMINE 4-aminobutan-1-ol 2-AcetyLhiophene 1-AMINO BUTANE-4-OL 13325-10-5 H2NCH24OH Amino Alcohols Building Blocks AMINE 蠅-Aminoalkanols 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides Organic Building Blocks Oxygen Compounds Amino Alcohols Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds omega-Aminoalkanols omega-Functional Alkanols, Carboxylic Acids, Amines & Halides Amino Alcohols Organic Building Blocks Oxygen Compounds Miscellaneous